International Journal of Molecular Sciences,
Год журнала:
2018,
Номер
19(6), С. 1754 - 1754
Опубликована: Июнь 13, 2018
Dietary
compounds
that
possess
the
properties
of
altering
epigenetic
processes
are
gaining
popularity
as
targets
for
cancer
prevention
studies.
These
when
administered
at
optimal
concentrations
and
especially
in
combination
can
have
enhanced
effects
or
therapy.
It
is
important
to
study
interaction
two
more
order
assess
their
role
enhancing
prevention.
Genistein
(GEN),
found
soy,
has
been
extensively
studied
its
an
modifier
a
DNA
methyltransferase
(DNMT)
inhibitor
sulforaphane
(SFN),
cruciferous
vegetables,
known
histone
deacetylase
(HDAC)
inhibitor.
However,
very
little
about
these
conjunction
breast
In
our
current
study,
we
determined
that,
certain
doses,
synergistic
decreasing
cellular
viability
cell
lines.
Our
results
indicate
GEN
SFN
much
effective
than
single
doses
increasing
rate
apoptosis
lowering
colony
forming
potential
cells.
We
inhibit
cycle
progression
G2
phase
MDA-MB-231
G1
MCF-7
Additionally,
HDAC
(HMT)
Furthermore,
demonstrated
this
downregulates
levels
HDAC2
HDAC3
both
mRNA
protein
levels.
also
downregulate
KLF4
levels,
which
plays
stem
formation.
The
downregulating
hTERT
be
activated
binds
promoter
region.
hypothesis
further
strengthened
by
vivo
studies,
where
transgenic
mice
form
genistein
SFN-enriched
broccoli
sprouts.
preventing
treating
mammary
via
extending
tumor
latency
reducing
volumes/sizes
either
dietary
components
alone.
consistent
with
vitro
suggesting
preventive
therapeutic
novel
combinatorial
approach
against
cancer.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(10), С. 4375 - 4397
Опубликована: Июль 11, 2023
Abstract
Cancer
is
the
most
common
cause
of
death
worldwide,
following
cardiovascular
diseases.
a
multifactorial
disease
and
many
reasons
such
as
physical,
chemical,
biological,
lifestyle‐related
factors.
Nutrition,
which
one
various
factors
that
play
role
in
prevention,
development,
treatment
types
cancer,
affects
immune
system,
characterized
by
disproportionate
pro‐inflammatory
signaling
cancer.
Studies
investigating
molecular
mechanisms
this
effect
have
shown
foods
rich
bioactive
compounds,
green
tea,
olive
oil,
turmeric,
soybean
significant
positively
changing
expression
miRNAs
involved
regulation
genes
associated
with
oncogenic/tumor‐suppressing
pathways.
In
addition
to
these
foods,
some
diet
models
may
change
specific
cancer‐related
different
ways.
While
Mediterranean
has
been
anticancer
effects,
high‐fat
diet,
methyl‐restricted
are
considered
negative
effects.
This
review
aims
discuss
effects
called
“immune
foods,”
models,
components
on
cancer
prevention
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5556 - 5556
Опубликована: Май 20, 2024
The
most
common
malignancy
in
women
is
breast
cancer.
During
the
development
of
cancer,
oncogenic
transcription
factors
facilitate
overproduction
inflammatory
cytokines
and
cell
adhesion
molecules.
Antiapoptotic
proteins
are
markedly
upregulated
cancer
cells,
which
promotes
tumor
development,
metastasis,
survival.
Promising
findings
have
been
found
studies
on
cycle-mediated
apoptosis
pathway
for
medication
treatment.
Dietary
phytoconstituents
studied
great
detail
their
potential
to
prevent
by
triggering
body’s
defense
mechanisms.
underlying
mechanisms
action
may
be
clarified
considering
role
polyphenols
important
signaling
pathways.
Phenolic
acids,
flavonoids,
tannins,
coumarins,
lignans,
lignins,
naphthoquinones,
anthraquinones,
xanthones,
stilbenes
examples
natural
chemicals
that
being
anticancer
drugs.
These
substances
also
vital
This
review
focuses
innovations
study
polyphenol
genistein’s
effects
cells
presents
integrated
chemical
biology
methods
harness
therapeutic
advances.
International Journal of Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
The
concept
of
aging
has
evolved
from
being
primarily
attributed
to
genetic
factors
recognizing
the
critical
role
epigenetic
mechanisms.
Recent
advancements,
such
as
clocks,
have
provided
tools
assess
biological
age
and
offer
insights
into
processes
at
molecular
level.
In
aesthetic
dermatology,
understanding
these
allows
for
more
personalized,
effective
interventions
targeting
root
causes
skin
aging.
This
review
explores
interplay
changes,
aging,
potential
personalized
care
enhance
longevity
rejuvenation.
is
based
on
an
extensive
literature
search
conducted
across
PubMed
other
scientific
databases.
Studies
focused
mechanisms
DNA
methylation,
histone
modifications,
their
relationship
Particular
attention
was
given
recent
advancements
in
including
Horvath's
Clock
GrimAge,
implications
dermatological
treatments.
Epigenetic
Clock,
demonstrated
utility
assessing
through
methylation
markers,
revealing
actionable
processes.
Energy‐based
devices
like
fractional
lasers
radiofrequency
shown
promise
reversing
age‐related
promoting
collagen
synthesis,
reducing
age.
Additionally,
lifestyle
diet,
sleep,
circadian
rhythm
alignment
significantly
influence
health.
Integrating
dermatology
represents
a
paradigm
shift
rejuvenation,
allowing
treatments
that
address
visible
signs
underlying
Using
clocks
provides
framework
tailoring
individual
patient
needs,
optimizing
outcomes,
extending
results.
Future
research
should
focus
longitudinal
studies,
accessibility,
ethical
considerations
fully
harness
epigenetics
health
overall
well‐being.
Animal nutrition,
Год журнала:
2015,
Номер
1(3), С. 144 - 151
Опубликована: Сен. 1, 2015
It
is
well
known
that
phenotype
of
animals
may
be
modified
by
the
nutritional
modulations
through
epigenetic
mechanisms.
As
a
key
and
central
component
network,
DNA
methylation
labile
in
response
to
influences.
Alterations
profiles
can
lead
changes
gene
expression,
resulting
diverse
phenotypes
with
potential
for
decreased
growth
health.
Here,
I
reviewed
biological
process
results
addition
methyl
groups
DNA;
possible
ways
including
donors,
methyltransferase
(DNMT)
activity
other
cofactors,
critical
periods
prenatal,
postnatal
dietary
transition
periods,
tissue
specific
modulation
nutrition
its
mechanisms
animals.
Journal of Medicinal Chemistry,
Год журнала:
2014,
Номер
58(6), С. 2569 - 2583
Опубликована: Ноя. 19, 2014
DNA
methylation
is
a
mammalian
epigenetic
mark
that
involved
in
defining
where
and
when
genes
are
expressed,
both
normal
cells
the
context
of
diseases.
Like
other
marks,
it
reversible
can
be
modulated
by
chemical
agents.
Because
plays
an
important
role
cancer
silencing
certain
genes,
such
as
tumor
suppressor
reactivating
regions,
repeated
elements,
promising
therapeutic
target.
Two
compounds
already
approved
to
treat
hematological
cancers.
Many
efforts
have
been
carried
out
discover
new
molecules
able
efficiently
inhibit
cells.
We
will
briefly
overview
foremost
these
focusing
on
what
we
learned
this
point
non-nucleoside
inhibitors
consider
features
ideal
inhibitor.
Current Issues in Molecular Biology,
Год журнала:
2021,
Номер
43(3), С. 1502 - 1517
Опубликована: Окт. 10, 2021
Genistein
is
an
isoflavonoid
present
in
high
quantities
soybeans.
Possessing
a
wide
range
of
bioactives,
it
being
studied
extensively
for
its
tumoricidal
effects.
Investigations
into
mechanisms
the
anti-cancer
activity
have
revealed
many
pathways
including
induction
cell
proliferation,
suppression
tyrosine
kinases,
regulation
Hedgehog-Gli1
signaling,
modulation
epigenetic
activities,
seizing
cycle
and
Akt
MEK
signaling
pathways,
among
others
via
which
cancer
proliferation
can
be
controlled.
Notwithstanding,
observed
activities
been
time-
dose-dependent.
In
addition,
genistein
has
also
shown
varying
results
women
depending
on
physiological
parameters,
such
as
early
or
post-menopausal
states.
