Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12195 - 12195

Опубликована: Июль 30, 2023

Phytoestrogens (PEs) are estrogen-like nonsteroidal compounds derived from plants (e.g., nuts, seeds, fruits, and vegetables) fungi that structurally similar to 17β-estradiol. PEs bind all types of estrogen receptors, including ERα ERβ nuclear a membrane-bound receptor known as the G protein-coupled (GPER). As endocrine-disrupting chemicals (EDCs) with pro- or antiestrogenic properties, can potentially disrupt hormonal regulation homeostasis, resulting in developmental reproductive abnormalities. However, lack diet does not result development deficiency symptoms. To properly assess benefits risks associated use PE-rich diet, it is necessary distinguish between endocrine disruption (endocrine-mediated adverse effects) nonspecific effects on system. Endometriosis an estrogen-dependent disease unknown etiopathogenesis, which tissue lining uterus (the endometrium) grows outside subsequent complications being manifested local inflammatory reactions. affects 10–15% women age chronic pelvic pain, dysmenorrhea, dyspareunia, infertility. In this review, endocrine-disruptive actions reviewed context endometriosis determine whether has positive negative effect risk course endometriosis.

Язык: Английский

Molecular Pathways of Genistein Activity in Breast Cancer Cells DOI Open Access

Evangelia Konstantinou,

Aristea Gioxari,

Maria Dimitriou

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5556 - 5556

Опубликована: Май 20, 2024

The most common malignancy in women is breast cancer. During the development of cancer, oncogenic transcription factors facilitate overproduction inflammatory cytokines and cell adhesion molecules. Antiapoptotic proteins are markedly upregulated cancer cells, which promotes tumor development, metastasis, survival. Promising findings have been found studies on cycle-mediated apoptosis pathway for medication treatment. Dietary phytoconstituents studied great detail their potential to prevent by triggering body’s defense mechanisms. underlying mechanisms action may be clarified considering role polyphenols important signaling pathways. Phenolic acids, flavonoids, tannins, coumarins, lignans, lignins, naphthoquinones, anthraquinones, xanthones, stilbenes examples natural chemicals that being anticancer drugs. These substances also vital This review focuses innovations study polyphenol genistein’s effects cells presents integrated chemical biology methods harness therapeutic advances.

Язык: Английский

Процитировано

23

Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery DOI Creative Commons

Jibon Kumar Paul,

Mahir Azmal,

Anm Shah Newaz Been Haque

и другие.

Advances in Redox Research, Год журнала: 2024, Номер 13, С. 100113 - 100113

Опубликована: Авг. 31, 2024

Язык: Английский

Процитировано

19

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis DOI Creative Commons
Kailin Yang, Junpeng Chen, Tianqing Zhang

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Сен. 9, 2022

Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, some inconsistent results. The effectiveness dietary polyphenols in NAFLD still controversial. aim this study was to evaluate efficacy oral patients with NAFLD.The literature (both Chinese English) published before 30 April 2022 PubMed, Cochrane, Medline, CNKI, other databases on searched. Manual screening, quality assessment, data extraction search results were conducted strictly according inclusion exclusion criteria. RevMan 5.3 software used perform meta-analysis.The RCTs included involved supplementation eight (curcumin, resveratrol, naringenin, anthocyanin, hesperidin, catechin, silymarin, genistein) 2,173 participants. This systematic review meta-analysis found that 1) curcumin may decrease body mass index (BMI), Aspartate aminotransferase (AST), Alanine (ALT), Triglycerides (TG) total cholesterol (TC), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) compared placebo; does not increase occurrence adverse events. 2) Although all randomized controlled trials (RCTs) did reveal significant positive changes, individual showed meaningful 3) Naringenin significantly decreased percentage grade, TG, TC, low-density lipoprotein (LDL-C) increased high-density (HDL-C) but had no effect AST ALT, it safe supplementation. 4) Only one team presents protocol about anthocyanin (from Cornus mas L. fruit extract) NAFLD. 5) Hesperidin BMI, AST, HOMA-IR, so on. 6) Catechin TG level, well tolerated by patients. 7) Silymarin improving ALT reducing hepatic fat accumulation stiffness patients.Based current evidence, can reduce enzymes, insulin resistance; catechin resistance, effectively; silymarin enzymes. For more are needed further their safety.

Язык: Английский

Процитировано

56

Recent updates on anticancer mechanisms of polyphenols DOI Creative Commons
Eshita Sharma, Dharam Chand Attri,

Priyanka Sati

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Сен. 29, 2022

In today’s scenario, when cancer cases are increasing rapidly, anticancer herbal compounds become imperative. Studies on the molecular mechanisms of action polyphenols published in specialized databases such as Web Science, Pubmed/Medline, Google Scholar, and Science Direct were used sources information for this review. Natural provide established efficacy against chemically induced tumor growth with fewer side effects. They can sensitize cells to various therapies increase effectiveness biotherapy. Further pharmacological translational research clinical trials needed evaluate theirs vivo efficacy, possible effects toxicity. Polyphenols be design a potential treatment conjunction existing drug regimens chemotherapy radiotherapy.

Язык: Английский

Процитировано

56

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches DOI Open Access
Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia

и другие.

Chemistry & Biodiversity, Год журнала: 2023, Номер 20(9)

Опубликована: Авг. 7, 2023

With the increasing prevalence of cancer and toxic side effects synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several activities. It obtained major compound from different Dioscorea species. This review was designated to summarize research progress on anti-cancer activities gracillin focusing underlying cellular molecular mechanisms, well its pharmacokinetic features. The data were collected (up date May 1, 2023) various reliable authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings demonstrated that displays anticancer through including anti-inflammatory effects, apoptotic cell death, induction oxidative stress, cytotoxicity, genotoxicity, cycle arrest, anti-proliferative effect, autophagy, inhibition glycolysis, blocking migration. Additionally, this highlighted features gracillin, indicating lower oral bioavailability. As conclusion, it can be proposed could serve hopeful chemotherapeutic agent. However, further extensive clinical recommended establish safety, efficacy, potential in treatment.

Язык: Английский

Процитировано

34

Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment DOI Creative Commons

Esma Karahmet Farhat,

Emina Karahmet Sher,

Amina Džidić-Krivić

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2023, Номер 118, С. 109368 - 109368

Опубликована: Апрель 25, 2023

The human gut is a host for trillions of microorganisms, divided into more than 3,000 heterogeneous species that called the microbiota. microbiota composition can be altered by many different endogenous and exogenous factors, especially diet nutrition. A rich in phytoestrogens, variable group chemical compounds similar to 17-β-estradiol (E2), essential female steroid sex hormone potent change However, metabolism phytoestrogens also highly depends on action enzymes produced Novel studies have shown could play an important role treatment types cancers, such as breast cancer women, due their potential decrease estrogen levels. This review aims summarize recent findings about lively dialogue between address possible future application, treating patients with diagnosed cancer. therapeutic approach prevention improving outcomes based targeted probiotic supplementation use soy phytoestrogens. positive effect probiotics outcome survival has been established. vivo scientific are needed pave way clinical practice treatment.

Язык: Английский

Процитировано

32

The Emerging Role of Natural Products in Cancer Treatment DOI
Sumit Ghosh, Sanjib Das, Krishnendu Sinha

и другие.

Archives of Toxicology, Год журнала: 2024, Номер 98(8), С. 2353 - 2391

Опубликована: Май 25, 2024

Язык: Английский

Процитировано

12

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

и другие.

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

2

Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics DOI Creative Commons
David B. Neale, Jonathan C. Morris, Nicole M. Verrills

и другие.

Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108834 - 108834

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2

Comparative metabolomics of flavonoids in twenty vegetables reveal their nutritional diversity and potential health benefits DOI
Han Tao, Yao Zhao, Linying Li

и другие.

Food Research International, Год журнала: 2022, Номер 164, С. 112384 - 112384

Опубликована: Дек. 28, 2022

Язык: Английский

Процитировано

32