Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100616 - 100616
Опубликована: Апрель 1, 2025
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 9, 2024
Язык: Английский
Процитировано
39
Neuron, Год журнала: 2023, Номер 112(3), С. 342 - 361
Опубликована: Ноя. 14, 2023
Physical forces are ubiquitous in biological processes across scales and diverse contexts. This review highlights the significance of mechanical nervous system development, homeostasis, disease. We provide an overview signals present delve into mechanotransduction mechanisms translating these cues biochemical signals. During regulate a plethora processes, including cell proliferation, differentiation, migration, network formation, cortex folding. Forces then continue exerting their influence on physiological such as neuronal activity, glial function, interplay between different types. Notably, changes tissue mechanics manifest neurodegenerative diseases brain tumors, potentially offering new diagnostic therapeutic target opportunities. Understanding role cellular physiology pathology adds facet to neurobiology, shedding light many that remain incompletely understood.
Язык: Английский
Процитировано
41
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 273, С. 116502 - 116502
Опубликована: Май 14, 2024
The cation channel Piezo1, a crucial mechanotransducer found in various organs and tissues, has gained considerable attention as therapeutic target recent years. Following this trend, several Piezo1 inhibitors have been discovered studied for potential pharmacological properties. This review provides an overview of the structural functional importance well discussing biological activities based on their mechanism action. compounds addressed include toxin GsMTx4, Aβ peptides, certain fatty acids, ruthenium red gadolinium, Dooku1, natural products tubeimoside I, salvianolic acid B, jatrorrhzine, escin. findings revealed that misexpression can be associated with number chronic diseases, including hypertension, cancer, hemolytic anemia. Consequently, inhibiting subsequent calcium influx beneficial effects pathological processes, shown by many vitro vivo studies. However, development is still its beginnings, opportunities challenges remaining to explored.
Язык: Английский
Процитировано
13
Neuroglia, Год журнала: 2024, Номер 5(4), С. 410 - 444
Опубликована: Окт. 21, 2024
Microglia, the unique and motile immune cells of central nervous system (CNS), function as a security guard in maintaining CNS homeostasis, primarily through calcium signaling. The dynamics microglia control important functions such phagocytosis, cytokine release, migration. Calcium dysregulation has been linked to several disorders, like Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), ischemic stroke (IS). entering channels voltage-gated (VGCCs), store-operated entry (SOCE), transient receptor potential (TRP) is essential for microglial activation pro-inflammatory responses. Under pathological conditions, formation amyloid-β plaques AD, aggregation α-synuclein PD, oxidative stress MS, exacerbates neuroinflammation, mitochondrial dysfunction, neurodegeneration. Therapeutic strategies targeting signaling pathways, using channel blockers antioxidant interventions, show promise alleviating slowing down progression. This review summarizes underlying mechanisms therapeutic benefits restoring balance disorders.
Язык: Английский
Процитировано
10
Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 4, 2025
Osteoarthritis (OA) significantly impacts the elderly, leading to disability and decreased quality of life. While hyaluronic acid (HA) chondroitin sulfate (CS) are recognized for their therapeutic potential in OA, effects on extracellular matrix (ECM) degradation not well understood. This study investigates impact HA CS, individually combined, ECM OA underlying mechanisms.
Язык: Английский
Процитировано
2
Brain and Behavior, Год журнала: 2023, Номер 13(9)
Опубликована: Июнь 27, 2023
Abstract Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of tissue influence many physiological pathological processes. Piezo type ion channel component 1 (Piezo1), protein found metazoans, expressed involved sensing microenvironment. Numerous studies have shown that Piezo1‐mediated mechanotransduction closely related to glial cell activation neuronal function. However, precise role Piezo1 requires further elucidation. Objective This review first discusses roles regulating functions variety cells, then briefly assesses impact on progression dysfunctional disorders. Conclusions Mechanical signaling contributes significantly regulates processes such as differentiation, migration, axon guidance, neural regeneration, oligodendrocyte myelination. Additionally, plays significant normal aging injury, well development various diseases, including demyelinating Alzheimer's disease, tumors. Investigating pathophysiological mechanisms through which affects function will give us novel entry point for diagnosis treatment numerous diseases.
Язык: Английский
Процитировано
18
Biochemical Pharmacology, Год журнала: 2024, Номер 222, С. 116050 - 116050
Опубликована: Фев. 12, 2024
Язык: Английский
Процитировано
9
Cancer & Metabolism, Год журнала: 2025, Номер 13(1)
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
1
Immunity Inflammation and Disease, Год журнала: 2023, Номер 11(10)
Опубликована: Окт. 1, 2023
Abstract Objective Tissue injury and inflammation are two potential outcomes of cerebral ischemia–reperfusion (I/R) injury. Salvianolic acid B (Sal B), isolated from the roots Salvia miltiorrhiza , is one major water‐soluble compounds with a wide range pharmacological effects including antioxidant, anti‐inflammatory, antiproliferative, neuroprotective effects. In present study, we explored mechanisms Sal after I/R Methods We induced ischemia in male CD‐1 mice through transient (60 min) middle artery occlusion (tMCAO), then injected (30 mg/kg) intraperitoneally. Neurological deficits, infarct volumes, brain edema were assessed at 24 72 h tMCAO. detected expression Toll‐like receptor 4 (TLR4), phosphorylated‐p38 mitogen‐activated protein kinase (P‐p38 MAPK), phosphorylated c‐Jun amino (N)‐terminal kinases (p‐JNK), nuclear factor‐κB (NF‐κB), interleukin‐1β (IL‐1β) tissue. Results Compared tMCAO group, significantly improved neurological reduced size, attenuated edema, downregulated pro‐inflammatory mediators TLR4, p‐p38MAPK, p‐JNK, NF‐κB, IL‐1β tissue Conclusion found that protects tissues by activating its anti‐inflammatory properties.
Язык: Английский
Процитировано
10
Frontiers in Molecular Biosciences, Год журнала: 2023, Номер 10
Опубликована: Окт. 12, 2023
Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat global health. Early treatment of fibrosis has been reported be the turning point, therefore, exploring potential correlates pathogenesis how reverse become pressing issue. As mechanism-sensitive cationic calcium channel, Piezo1 turns on response changes lipid bilayer plasma membrane. exerts multiple biological roles, including inhibition inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, immune cell mechanotransduction, interestingly enough. These processes are closely associated with development fibrotic diseases. Recent studies have shown that deletion or knockdown attenuates onset fibrosis. Therefore, this paper we comprehensively describe biology gene, focusing its relevance pulmonary fibrosis, renal pancreatic cardiac diseases, except for role drugs (agonists), increased intracellular mechanical stress using gene alleviating
Язык: Английский
Процитировано
9