Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

Nature Reviews Neurology, Год журнала: 2022, Номер 18(5), С. 273 - 288

Опубликована: Март 29, 2022

Язык: Английский

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Prefrontal cortex, amygdala, and threat processing: implications for PTSD

Neuropsychopharmacology, Год журнала: 2021, Номер 47(1), С. 247 - 259

Опубликована: Сен. 20, 2021

Abstract Posttraumatic stress disorder can be viewed as a of fear dysregulation. An abundance research suggests that the prefrontal cortex is central to processing—that is, how fears are acquired and strategies regulate or diminish responses. The current review covers foundational on threat acquisition extinction in nonhuman animals, healthy humans, patients with posttraumatic disorder, through lens involvement these processes. Research harnessing advances technology further probe role processes, such use optogenetics rodents brain stimulation will highlighted, well other regulation approaches relevant treatment involve cortex, namely cognitive avoidance/active coping. Despite large body translational research, many questions remain unanswered remains difficult treat. We conclude by outlining future directions related processing implications for disorder.

Язык: Английский

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Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

Nature Neuroscience, Год журнала: 2020, Номер 23(3), С. 398 - 410

Опубликована: Фев. 17, 2020

Язык: Английский

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Multiple large-scale neural networks underlying emotion regulation

Neuroscience & Biobehavioral Reviews, Год журнала: 2020, Номер 116, С. 382 - 395

Опубликована: Июль 11, 2020

Язык: Английский

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Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Current Neuropharmacology, Год журнала: 2023, Номер 22(4), С. 557 - 635

Опубликована: Май 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Язык: Английский

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Post‐traumatic stress disorder: evolving conceptualization and evidence, and future research directions

World Psychiatry, Год журнала: 2025, Номер 24(1), С. 52 - 80

Опубликована: Янв. 15, 2025

The understanding of responses to traumatic events has been greatly influenced by the introduction diagnosis post‐traumatic stress disorder (PTSD). In this paper we review initial versions diagnostic criteria for condition and associated epidemiological findings, including sociocultural differences. We consider evidence reactions occurring in multiple contexts not previously defined as traumatic, implications that these observations have diagnosis. More recent developments such DSM‐5 dissociative subtype ICD‐11 complex PTSD are reviewed, adding there several distinct phenotypes. describe psychological foundations PTSD, involving disturbances memory well identity. A broader focus on identity may be able accommodate group communal influences experience trauma impact resource loss. then summarize current concerning biological with a particular genetic neuroimaging studies. Whereas progress prevention disappointing, is now an extensive supporting efficacy variety treatments established trauma‐focused interventions – cognitive behavior therapy (TF‐CBT) eye movement desensitization reprocessing (EMDR) non‐trauma‐focused therapies, which also include some emerging identity‐based approaches present‐centered compassion‐focused therapies. Additionally, promising neither nor pharmacological, or combine pharmacological approach, 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy. advances priority areas adapting resource‐limited settings across cultural contexts, community‐based approaches. conclude identifying future directions work mental health.

Язык: Английский

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Functional Neuroanatomy of Emotion and Its Regulation in PTSD

Harvard Review of Psychiatry, Год журнала: 2018, Номер 26(3), С. 116 - 128

Опубликована: Май 1, 2018

Abstract Posttraumatic stress disorder (PTSD) is a devastating disorder, linked to profound mental, physical, occupational, and functional impairment. In addition, it highly complex characterized by symptom heterogeneity across multiple domains. Nevertheless, emotion dysregulation arising from the exaggerated response threat or inability regulate negative emotional states plays defining role in pathophysiology of PTSD. order improve our understanding how manifests this illness, neuroimaging research over past 20 years provides great insight into underlying neuroanatomy each component context While prior reviews exist on topic findings PTSD, present review synthesizes that work through lens its regulation. Studies employed tasks responding provocation, implicit regulation (e.g., Stroop interference), explicit cognitive reappraisal), fear conditioning/extinction were reviewed. Findings demonstrate PTSD arises complications within large neurocircuitry involving amygdala, insula, hippocampus, anterior cingulate cortex, prefrontal cortex. Although an amygdala insula triggers pervasive, also marked deficient appraisal, resolution, management subserved cortex during These further support importance studying emotion-regulation deficits tandem with provocation better understand constellation symptoms those

Язык: Английский

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Deconstructing the Gestalt: Mechanisms of Fear, Threat, and Trauma Memory Encoding

Neuron, Год журнала: 2019, Номер 102(1), С. 60 - 74

Опубликована: Апрель 1, 2019

Язык: Английский

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A Review of the Neurobiological Basis of Trauma-Related Dissociation and Its Relation to Cannabinoid- and Opioid-Mediated Stress Response: a Transdiagnostic, Translational Approach

Current Psychiatry Reports, Год журнала: 2018, Номер 20(12)

Опубликована: Ноя. 7, 2018

Язык: Английский

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Emotional valence modulates the topology of the parent-infant inter-brain network

NeuroImage, Год журнала: 2019, Номер 207, С. 116341 - 116341

Опубликована: Ноя. 8, 2019

Emotional communication between parents and children is crucial during early life, yet little known about its neural underpinnings. Here, we adopt a dual connectivity approach to assess how positive negative emotions modulate the interpersonal network infants their mothers naturalistic interaction. Fifteen were asked model toward pairs of objects social interaction with (mean age 10.3 months) whilst activity both was concurrently measured using electroencephalography (EEG). Intra-brain inter-brain in 6-9 Hz range (i.e. infant Alpha band) maternal expression computed directed (partial coherence, PDC) non-directed (phase-locking value, PLV) metrics. Graph theoretical measures used quantify differences topology as function emotional valence. We found that indices (Density, Strength Divisibility) consistently revealed strong effects valence on parent-child network. Parents showed stronger integration processes demonstrations than emotions. Further, metrics (PDC) indicated mother directional influences states. These results suggest parent-infant modulated by quality tone dyadic interactions, graph may be successfully applied examine these changes topology.

Язык: Английский

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