TRIB3–TRIM8 complex drives NAFLD progression by regulating HNF4α stability

Journal of Hepatology, Год журнала: 2024, Номер 80(5), С. 778 - 791

Опубликована: Янв. 21, 2024

Язык: Английский

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Homeostasis control in health and disease by the unfolded protein response

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Язык: Английский

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Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs

Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119200 - 119200

Опубликована: Дек. 3, 2024

Язык: Английский

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Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis

Chemico-Biological Interactions, Год журнала: 2024, Номер 398, С. 111104 - 111104

Опубликована: Июнь 19, 2024

Язык: Английский

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(+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 20, 2024

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress play significant roles NAFLD pathogenesis. The unfolded protein response mitochondria (UPRmt) an adaptive mechanism that aims to restore mitochondrial homeostasis mitigate cellular stress. This study aimed investigate effects ( +)-Lipoic acid (ALA) on UPRmt, inflammation, oxidative vitro model using HepG2 cells treated with palmitic oleic induce steatosis. Results Treatment acids increased UPRmt-related proteins HSP90 HSP60 (heat shock protein), decreased CLPP (caseinolytic protease P), indicating ER activation. ALA treatment at 1 μM 5 restored levels. PA:OA (palmitic acid:oleic acid)-induced markers IRE1α (Inositol requiring enzyme-1), CHOP (C/EBP Homologous Protein), BIP (Binding Immunoglobulin BAX (Bcl-2-associated X protein) were significantly reduced treatment. also enhanced ER-mediated glycosylation stress, as evidenced GPX1 (Glutathione peroxidase 1), GSTP1 (glutathione S-transferase pi GSR (glutathione-disulfide reductase) expression GSH (Glutathione) levels, improved senescence shown β-galactosidase, γH2Ax Klotho-beta. Conclusions In conclusion, ameliorated inflammation acids, potentially offering therapeutic benefits for providing possible biochemical underlying beneficial effects. Graphical

Язык: Английский

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Crosstalk between Endoplasmic Reticulum Stress and Ferroptosis in Liver Diseases

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(6), С. 221 - 221

Опубликована: Июнь 20, 2024

The endoplasmic reticulum (ER) played an important role in the folding, assembly and post-translational modification of proteins. ER homeostasis could be disrupted by accumulation misfolded proteins, elevated reactive oxygen species (ROS) levels, abnormal Ca2+ signaling, which was referred to stress (ERS). Ferroptosis a unique programmed cell death model mediated iron-dependent phospholipid peroxidation multiple signaling pathways. changes mitochondrial structure, damage glutathione peroxidase 4 (GPX4) excess iron were main characteristics ferroptosis. ROS produced ferroptosis can interfere with activity protein-folding enzymes, leading large amounts unfolded thus causing ERS. On contrary, increase ERS level promote ion lipid peroxide, up-regulation related genes. At present, studies on relationship between one-sided lack in-depth interaction mechanism. This review aimed explore molecular mechanism cross-talk ERS, provide new strategies targets for treatment liver diseases.

Язык: Английский

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Multifunctional integrated polyphenol-copper nanozymes for sepsis-induced acute liver injury via ameliorating endoplasmic reticulum stress and reprogramming inflammatory microenvironment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160293 - 160293

Опубликована: Фев. 1, 2025

Язык: Английский

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Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Язык: Английский

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Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Язык: Английский

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Protective role of sulforaphane in lipid metabolism-related diseases

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 17, 2025

Язык: Английский

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