Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 706 - 706
Опубликована: Июнь 9, 2024
α-lipoic
acid
is
a
naturally
occurring
compound
with
potent
antioxidant
properties
that
helps
protect
cells
and
tissues
from
oxidative
stress.
Its
incorporation
into
nanoplatforms
can
affect
factors
like
bioavailability,
stability,
reactivity,
targeted
delivery.
Nanoformulations
of
significantly
enhance
its
solubility
absorption,
making
it
more
bioavailable.
While
be
prone
to
degradation
in
free
form,
encapsulation
within
nanoparticles
ensures
stability
over
time,
release
controlled
sustained
manner
the
cells.
In
addition,
combined
other
compounds,
such
as
antioxidants,
drugs,
or
nanomaterials,
create
synergistic
effects
their
overall
therapeutic
benefits
hinder
potential
cytotoxicity.
This
review
outlines
advantages
drawbacks
associated
use
acid,
well
various
nanotechnological
approaches
employed
effectiveness,
whether
alone
combination
bioactive
agents.
Furthermore,
describes
engineering
produce
poly(α-lipoic
acid)
nanoparticles,
which
hold
promise
an
effective
drug
delivery
system.
Язык: Английский
A near infrared fluorescent probe for monitoring peroxynitrite abnormalities in non-alcoholic fatty liver
Microchemical Journal,
Год журнала:
2024,
Номер
205, С. 111195 - 111195
Опубликована: Июль 14, 2024
Язык: Английский
Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review
Archives of Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
heterogeneous
condition
characterized
by
steatosis,
inflammation,
consequent
fibrosis,
and
cirrhosis.
Chronic
impairment
of
lipid
metabolism
closely
related
to
oxidative
stress,
leading
cellular
lipotoxicity,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress.
The
detrimental
effect
stress
usually
accompanied
changes
in
antioxidant
defense
mechanisms,
with
the
alterations
enzymes
expression/activities
during
MASLD
development
progression
reported
many
clinical
experimental
studies.
This
review
will
provide
comprehensive
overview
present
research
on
MASLD-induced
catalytic
activity
expression
main
(superoxide
dismutases,
catalase,
glutathione
peroxidases,
S-transferases,
reductase,
NAD(P)H:quinone
oxidoreductase)
level
non-enzymatic
glutathione.
Furthermore,
an
therapeutic
effects
vitamin
E
be
presented.
Generally,
at
beginning
development,
expression/activity
increases
protect
organisms
against
increased
production
reactive
oxygen
species.
However,
advanced
stage
MASLD,
several
antioxidants
generally
decreases
due
damage
hepatic
extrahepatic
cells,
which
further
exacerbates
damage.
Although
results
obtained
patients,
various
animal
or
cell
models
have
been
inconsistent,
taken
together
importance
has
clearly
shown.
Язык: Английский
Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 14, 2025
Clonal
myeloproliferation
and
fibrotic
transformation
of
the
bone
marrow
(BM)
are
pathogenetic
events
most
commonly
occurring
in
myelofibrosis
(MF).
There
is
great
evidence
indicating
that
tumor
microenvironment
characterized
by
high
lactate
levels,
acting
not
only
as
an
energetic
source,
but
also
a
signaling
molecule.
To
test
involvement
MF
milieu
transformation,
we
measured
its
levels
patients'
sera,
eventually
finding
massive
accumulation
this
metabolite,
which
showed
to
promote
expansion
immunosuppressive
subsets.
Therefore,
assess
significance
trafficking,
inhibited
monocarboxylate
transporter
1
(MCT1)
selective
antagonist,
AZD3965,
mitigation
lactate-mediated
subsets
expansion.
further
dig
into
impact
microenvironment,
evaluated
effect
metabolite
on
mesenchymal
stromal
cells
(MSCs)
reprogramming.
Our
results
show
activation
cancer-associated
phenotype
(CAF)
related
mineralized
matrix
formation
early
fibrosis
development.
Strikingly,
serum,
enriched
lactate,
causes
strong
deposition
collagen
healthy
cells,
was
restrained
AZD3965.
corroborate
these
outcomes,
therefore
generated
for
first
time
TPOhigh
zebrafish
model
establishment
experimental
fibrosis.
By
adopting
model,
were
able
unveil
remarkable
increase
concentration
expression
site
hematopoiesis,
associated
with
downregulation
export
channel
MCT4.
Notably,
exploiting
MCTs
biopsy
specimens
from
patients
myeloproliferative
neoplasms,
found
loss
MCT4
PMF,
corroborating
changes
MCT
during
BM
establishment.
In
conclusion,
our
key
regulator
immune
escape
patients,
suggesting
MCT1
blocking
novel
antifibrotic
strategy.
Язык: Английский
A look at MERCs as UPRmt regulatory hubs in age-associated heart diseases
The Journal of Cardiovascular Aging,
Год журнала:
2025,
Номер
5(1)
Опубликована: Янв. 22, 2025
With
the
increase
in
life
expectancy
globally,
challenge
of
dealing
with
aging
becomes
more
prominent.
Aging
is
a
risk
factor
for
several
diseases,
including
cardiovascular
disease.
Mitochondria,
which
have
long
been
studied
relation
to
aging,
play
crucial
role
maintaining
cellular
homeostasis.
However,
there
limitation
interorganellar
communication
as
organisms
age.
The
unfolded
protein
response
mitochondria
(UPRmt)
activated
during
stress
maintain
mitochondrial
homeostasis
and
prevent
accumulation
damaged
mitochondria.
This
involves
signaling
from
nucleus,
leading
transcriptional
changes.
In
context
heart,
this
review
explores
terms
function
morphology.
It
also
discusses
impact
UPRmt
on
cardiac
diseases
such
heart
failure,
acute
myocardial
infarction,
dilated
cardiomyopathy.
highlights
potential
mitochondria-endoplasmic
reticulum
contact
sites
(MERCs)
modulating
aging.
Finally,
it
provides
an
update
molecules
that
induce
activity,
potentially
benefiting
Язык: Английский
Protective Effect of Lipoic Acid on Oxidative Stress and Tissue Damage Induced by Aflatoxin B1 in Young Laying Hens
Toxins,
Год журнала:
2025,
Номер
17(4), С. 184 - 184
Опубликована: Апрель 6, 2025
The
aim
of
this
study
is
to
investigate
the
alleviating
effect
lipoic
acid
on
oxidative
stress
and
tissue
damage
induced
by
aflatoxin
B1
(AFB1)
in
young
laying
hens.
experiment
was
divided
into
a
control
group,
an
AFB1
three
treatment
groups.
group
groups
were
given
diets
supplemented
with
90
μg/kg
AFB1.
additional
amounts
20,
100,
500
mg/kg,
respectively,
feeding
period
4
weeks.
experimental
results
showed
that
significantly
increased
levels
alanine
aminotransferase
(ALT),
aspartate
(AST),
alkaline
phosphatase
(ALP)
malondialdehyde
(MDA)
serum
decreased
total
protein
(TP),
albumin
(ALB),
superoxide
dismutase
(T-SOD),
glutathione
peroxidase
(GSH-Px)
catalase
(CAT)
(p
<
0.05).
In
addition,
damaged
structure
liver,
spleen,
ovarian
tissues.
Lipoic
reduced
ALT,
AST,
ALP,
MDA
TP,
ALB,
T-SOD,
GSH-Px,
CAT
Meanwhile,
also
protected
mitochondrial
alleviated
caused
summary,
can
alleviate
Язык: Английский
Comparative evaluation of cigarette smoke and a heated tobacco product on microglial toxicity, oxidative stress and inflammatory response
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 30, 2024
Язык: Английский
Heat shock proteins (HSPs) in non-alcoholic fatty liver disease (NAFLD): from molecular mechanisms to therapeutic avenues
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Окт. 12, 2024
Abstract
Non-alcoholic
fatty
liver
disease
(NAFLD),
a
spectrum
of
conditions
characterized
by
fat
accumulation
without
excessive
alcohol
consumption,
represents
significant
global
health
burden.
The
intricate
molecular
landscape
underlying
NAFLD
pathogenesis
involves
lipid
handling,
inflammation,
oxidative
stress,
and
mitochondrial
dysfunction,
with
endoplasmic
reticulum
(ER)
stress
emerging
as
key
contributor.
ER
triggers
the
unfolded
protein
response
(UPR),
impacting
hepatic
steatosis
in
contributing
to
fibrosis,
progression
NASH
eventually
hepatocellular
carcinoma
(HCC).
Heat
shock
proteins
(HSPs),
including
small
HSPs
such
HSP20
HSP27,
HSP60,
HSP70,
GRP78,
HSP90,
are
integral
cellular
responses.
They
aid
folding,
prevent
aggregation,
facilitate
degradation,
thus
mitigating
damage
under
conditions.
In
NAFLD,
aberrant
HSP
expression
function
contribute
pathogenesis.
Understanding
specific
roles
subtypes
offers
insights
into
potential
therapeutic
interventions.
This
review
discusses
involvement
pathophysiology
highlights
their
potential.
By
elucidating
mechanisms
HSP-mediated
protection
this
article
aims
pave
way
for
development
targeted
therapies
prevalent
disorder.
Язык: Английский
Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1461 - 1461
Опубликована: Ноя. 28, 2024
Low
molecular
weight
(LMW)
thiols,
particularly
glutathione,
play
pathogenic
roles
in
various
multiorgan
diseases.
The
liver
is
central
for
the
production
and
systemic
distribution
of
LMW
thiols;
thus,
it
susceptible
to
imbalance
redox
status
that
may
determine
increased
oxidative
stress
trigger
damage
observed
metabolic
dysfunction-associated
steatotic
disease
(MASLD)
models
humans.
Indeed,
thiols
at
cellular
extracellular
levels
be
associated
with
severity
MASLD.
Here,
we
present
a
systematic
literature
review
recent
studies
assessing
MASLD
vivo
vitro
human
subjects.
Based
on
PRISMA
2020
criteria,
search
was
conducted
using
PubMed
Scopus
by
applying
inclusion/exclusion
filters.
initial
returned
1012
documents,
from
which
165
eligible
were
selected,
further
described,
qualitatively
analysed.
Of
these
studies,
most
focused
animal
models,
while
minority
used
fluids.
analysis
revealed
heterogeneity
methods
sample
processing
measurement
thiol
levels,
hinder
cut-off
values
diagnostic
use.
Standardisation
measure
necessary
facilitate
future
studies.
Язык: Английский