Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Integrating
biomarkers
into
a
comprehensive
strategy
is
crucial
for
precise
patient
management,
especially
considering
the
significant
healthcare
costs
associated
with
diseases.
Current
studies
emphasize
urgent
need
paradigm
shift
in
conceptualizing
nonalcoholic
fatty
liver
disease
(NAFLD),
now
renamed
metabolic
dysfunction–associated
steatotic
(MASLD).
Biomarkers
are
emerging
as
indispensable
tools
accurate
diagnosis,
risk
stratification,
and
monitoring
progression.
This
review
classifies
conventional
novel
categories,
such
lipids,
insulin
resistance,
hepatic
function,
cutting-edge
imaging/omics,
evaluates
their
potential
to
transform
approach
MASLD
among
individuals
type
2
diabetes
mellitus
(T2D).
It
focuses
on
critical
role
of
early
detection,
enhancing
predictive
accuracy,
discerning
responses
interventions
(pharmacological
or
lifestyle
modifications).
Amid
this
discussion,
complexities
relationship
between
T2D
explored,
factors
like
age,
gender,
genetics,
ethnicity,
socioeconomic
background.
enhance
effectiveness
support
global
initiatives
reduce
burden
MASLD,
thereby
improving
public
health
outcomes.
recognizes
promising
diagnostic
precision
while
candidly
addressing
challenges
implementing
these
advancements
clinical
practice.
The
transformative
emerges
central
theme,
reshape
our
understanding
trajectories,
prognosis,
customization
personalized
therapeutic
strategies
improved
From
future
perspective,
identifying
early-stage
biomarkers,
environmental
impact
through
exposomes,
applying
multiomics
may
reveal
additional
insight
development.
International Journal of Biological Sciences,
Год журнала:
2023,
Номер
20(1), С. 113 - 126
Опубликована: Ноя. 15, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
global
health
burden
closely
linked
to
insulin
resistance,
obesity,
and
type
2
diabetes.
The
complex
pathophysiology
of
NAFLD
involves
multiple
cellular
pathways
molecular
factors.
Nuclear
receptors
(NRs)
have
emerged
as
crucial
regulators
lipid
metabolism
inflammation
in
NAFLD,
offering
potential
therapeutic
targets
for
NAFLD.
Targeting
PPARs
FXRs
has
shown
promise
ameliorating
symptoms
halting
progression.
However,
further
investigation
needed
address
side
effects
personalize
therapy
approaches.
This
review
summarizes
the
current
understanding
involvement
NRs
pathogenesis
explores
their
potential.
We
discuss
role
several
modulating
homeostasis
liver,
including
peroxisome
proliferator-activated
(PPARs),
X
(LXRs),
farnesoid
(FXRs),
REV-ERB,
hepatocyte
nuclear
factor
4α
(HNF4α),
constitutive
androstane
receptor
(CAR)
pregnane
(PXR).The
expanding
knowledge
offers
new
avenues
targeted
therapies,
necessitating
exploration
novel
treatment
strategies
optimization
existing
approaches
combat
this
increasingly
prevalent
disease.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 24, 2024
Metabolic
factors
play
a
critical
role
in
the
development
of
digestive
system
cancers
(DSCs),
and
East
Asia
has
highest
incidence
malignant
tumors
system.
We
performed
two-sample
Mendelian
randomization
analysis
to
explore
associations
between
19
metabolism-related
lifestyle
clinical
risk
DSCs,
including
esophageal,
gastric,
colorectal,
hepatocellular,
biliary
tract,
pancreatic
cancer.
The
causal
association
was
explored
for
all
combinations
each
factor
DSC.
gathered
information
on
instrumental
variables
(IVs)
from
various
sources
retrieved
outcome
Biobank
Japan
(BBJ).
data
were
studies
east
Asian
populations.
Finally,
17,572
DSCs
cases
195,745
controls
included.
Our
found
that
genetically
predicted
alcohol
drinking
strong
indicator
gastric
cancer
(odds
ratio
(OR)
=
0.95;
95%
confidence
interval
(CI):
0.93-0.98)
hepatocellular
carcinoma
(OR
1.11;
CI:
1.05-1.18),
whereas
coffee
consumption
had
potential
protective
effect
0.69;
0.53-0.90).
Triglyceride
potentially
associated
with
decreased
tract
0.53;
0.34-0.81),
uric
acid
0.59;
0.37-0.96).
syndrome
(MetS)
esophageal
Additionally,
there
no
evidence
other
factors,
body
mass
index,
waist
circumference,
waist-to-hip
ratio,
educational
levels,
lipoprotein
cholesterol,
total
glycine,
creatinine,
gout,
Graves'
disease,
DSCs.
leave-one-out
revealed
single
nucleotide
polymorphism
(SNP)
rs671
ALDH2
gene
disproportionately
high
contribution
carcinoma,
as
well
carcinoma.
present
study
multiple
valuable
SNP
highlighting
significance
metabolic
both
prevention
treatment
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 25, 2024
Thyroid
hormones
(THs)
have
been
found
that
it
is
closely
associated
with
the
onset
and
progression
of
non-alcoholic
fatty
liver
disease
(NAFLD).
However,
current
study
could
not
verify
intrinsic
relationship
between
thyroid
NAFLD,
which
requires
further
research.
The
searches
studies
reported
both
TH
level
in
serum
NAFLD
were
performed
PubMed,
Web
Science,
Cochrane
Library,
Embase
databases.
We
combined
an
overall
meta-analysis
a
dose-response
to
assess
correlation
function
levels
risk
NAFLD.
Overall,
10
included
total
38,425
individuals.
non-linear
model
showed
for
every
1
ng/dL
increase
FT4,
was
reduced
by
10.56%
(p=0.003).
odds
ratios
(ORs)
high
free
triiodothyronine
(FT3)
exposure
compared
those
low
FT3
1.580
(95%
CI
1.370
1.830,
I2
=
0.0%,
p<0.001)
meta-analysis.
continuous
variable
indicated
individuals
TSH
(SMD=1.32,
95%
0.660
1.970,
had
significantly
higher
fibrosis
than
levels.
Our
findings
only
validate
there
occurrence
abnormal
THs,
expected
more
observational
will
still
be
conducted
future
demonstrate
Registered
number
PROSPERO:
CRD42023405052.
Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Integrating
biomarkers
into
a
comprehensive
strategy
is
crucial
for
precise
patient
management,
especially
considering
the
significant
healthcare
costs
associated
with
diseases.
Current
studies
emphasize
urgent
need
paradigm
shift
in
conceptualizing
nonalcoholic
fatty
liver
disease
(NAFLD),
now
renamed
metabolic
dysfunction–associated
steatotic
(MASLD).
Biomarkers
are
emerging
as
indispensable
tools
accurate
diagnosis,
risk
stratification,
and
monitoring
progression.
This
review
classifies
conventional
novel
categories,
such
lipids,
insulin
resistance,
hepatic
function,
cutting-edge
imaging/omics,
evaluates
their
potential
to
transform
approach
MASLD
among
individuals
type
2
diabetes
mellitus
(T2D).
It
focuses
on
critical
role
of
early
detection,
enhancing
predictive
accuracy,
discerning
responses
interventions
(pharmacological
or
lifestyle
modifications).
Amid
this
discussion,
complexities
relationship
between
T2D
explored,
factors
like
age,
gender,
genetics,
ethnicity,
socioeconomic
background.
enhance
effectiveness
support
global
initiatives
reduce
burden
MASLD,
thereby
improving
public
health
outcomes.
recognizes
promising
diagnostic
precision
while
candidly
addressing
challenges
implementing
these
advancements
clinical
practice.
The
transformative
emerges
central
theme,
reshape
our
understanding
trajectories,
prognosis,
customization
personalized
therapeutic
strategies
improved
From
future
perspective,
identifying
early-stage
biomarkers,
environmental
impact
through
exposomes,
applying
multiomics
may
reveal
additional
insight
development.
