Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 24, 2024
Metabolic
factors
play
a
critical
role
in
the
development
of
digestive
system
cancers
(DSCs),
and
East
Asia
has
highest
incidence
malignant
tumors
system.
We
performed
two-sample
Mendelian
randomization
analysis
to
explore
associations
between
19
metabolism-related
lifestyle
clinical
risk
DSCs,
including
esophageal,
gastric,
colorectal,
hepatocellular,
biliary
tract,
pancreatic
cancer.
The
causal
association
was
explored
for
all
combinations
each
factor
DSC.
gathered
information
on
instrumental
variables
(IVs)
from
various
sources
retrieved
outcome
Biobank
Japan
(BBJ).
data
were
studies
east
Asian
populations.
Finally,
17,572
DSCs
cases
195,745
controls
included.
Our
found
that
genetically
predicted
alcohol
drinking
strong
indicator
gastric
cancer
(odds
ratio
(OR)
=
0.95;
95%
confidence
interval
(CI):
0.93-0.98)
hepatocellular
carcinoma
(OR
1.11;
CI:
1.05-1.18),
whereas
coffee
consumption
had
potential
protective
effect
0.69;
0.53-0.90).
Triglyceride
potentially
associated
with
decreased
tract
0.53;
0.34-0.81),
uric
acid
0.59;
0.37-0.96).
syndrome
(MetS)
esophageal
Additionally,
there
no
evidence
other
factors,
body
mass
index,
waist
circumference,
waist-to-hip
ratio,
educational
levels,
lipoprotein
cholesterol,
total
glycine,
creatinine,
gout,
Graves'
disease,
DSCs.
leave-one-out
revealed
single
nucleotide
polymorphism
(SNP)
rs671
ALDH2
gene
disproportionately
high
contribution
carcinoma,
as
well
carcinoma.
present
study
multiple
valuable
SNP
highlighting
significance
metabolic
both
prevention
treatment
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
20(1), P. 113 - 126
Published: Nov. 15, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
global
health
burden
closely
linked
to
insulin
resistance,
obesity,
and
type
2
diabetes.
The
complex
pathophysiology
of
NAFLD
involves
multiple
cellular
pathways
molecular
factors.
Nuclear
receptors
(NRs)
have
emerged
as
crucial
regulators
lipid
metabolism
inflammation
in
NAFLD,
offering
potential
therapeutic
targets
for
NAFLD.
Targeting
PPARs
FXRs
has
shown
promise
ameliorating
symptoms
halting
progression.
However,
further
investigation
needed
address
side
effects
personalize
therapy
approaches.
This
review
summarizes
the
current
understanding
involvement
NRs
pathogenesis
explores
their
potential.
We
discuss
role
several
modulating
homeostasis
liver,
including
peroxisome
proliferator-activated
(PPARs),
X
(LXRs),
farnesoid
(FXRs),
REV-ERB,
hepatocyte
nuclear
factor
4α
(HNF4α),
constitutive
androstane
receptor
(CAR)
pregnane
(PXR).The
expanding
knowledge
offers
new
avenues
targeted
therapies,
necessitating
exploration
novel
treatment
strategies
optimization
existing
approaches
combat
this
increasingly
prevalent
disease.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 5, 2024
Background:
Colorectal
cancer
and
Alzheimer’s
disease
are
both
common
life-threatening
diseases
in
the
elderly
population.
Some
studies
suggest
a
possible
inverse
relationship
between
colorectal
disease,
but
real-world
research
is
subject
to
many
biases.
We
hope
clarify
causal
two
through
bidirectional
two-sample
Mendelian
randomization
study.
Methods:
In
our
study,
we
used
genetic
summary
data
from
large-scale
genome-wide
association
investigate
disease.
Our
primary
analysis
employed
inverse-variance
weighted
method
also
complementary
techniques,
including
MR-Egger,
median
estimator,
Maximum
likelihood.
applied
simex
adjustment
MR-Egger
results.
utilized
MRlap
package
detect
potential
sample
overlap
its
impact
on
bias
of
addition,
performed
several
sensitivity
heterogeneity
analyses,
ensure
reliability
Results:
The
combined
effect
size
results
indicate
that
may
decrease
incidence
with
an
odds
ratio
(OR)
0.846
(95%
CI:
0.762–0.929).
Similar
were
observed
using
other
methods
such
as
On
hand,
slightly
increase
cancer,
OR
1.014
1.001–1.027).
However,
one
subgroup
not
significant,
indicated
introduced
into
Therefore,
reverse
validation
reliable.
F-statistic
for
all
SNPs
was
greater
than
20.
Four
related
outcome
excluded
Phenoscanner
website
did
affect
overall
direction
these
statistics
further
validated
by
MR-PRESSO,
funnel
plots,
leave-one-out
Cochran’s
Q,
demonstrating
findings.
Conclusion:
According
findings
this
there
appears
be
These
could
have
important
implications
clinical
practice
terms
how
treated.
To
better
understand
diseases,
more
screening
needed
settings.
Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 575 - 584
Published: Feb. 1, 2024
Background:
Type
2
diabetes
(T2DM)
combined
nonalcoholic
fatty
liver
disease
(NAFLD)
are
characterized
by
metabolic
disruptions.
Liraglutide
has
been
proved
to
be
effective
in
T2DM.
If
LRG
could
regulate
NAFLD
T2DM
not
reported.
Methods:
Intraperitoneal
injection
of
1%
streptozotocin
(STZ)
plus
high-sugar
and
high-fat
diet
was
used
induce
animal
model.
Palmitic
acid
(200
μmol/L)
glucose
(25
mmol/L)
incubation
were
cell
The
apoptosis,
mRNA
protein
expression
measured
through
flow
cytometry,
PCR,
Western
blotting,
respectively.
Results:
significantly
improved
the
injury
rats,
but
Com-C
reversed
effect
liraglutide.
decreased
AMPK/mTOR
signaling
pathway
animals
greatly
activated
protection
effects
liraglutide
on
palmitic
acid+glucose
induced
damage.
Conclusion:
alleviate
damage
caused
NAFLD+T2DM
acid+glucose.
inhibited
suppressing
pathway.
This
research
might
provide
a
novel
therapeutic
strategy
for
prevention
treatment
disease.
Keywords:
type
diabetes,
disease,
liraglutide,
AMPK/mTOR,
autophagy
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 24, 2024
Metabolic
factors
play
a
critical
role
in
the
development
of
digestive
system
cancers
(DSCs),
and
East
Asia
has
highest
incidence
malignant
tumors
system.
We
performed
two-sample
Mendelian
randomization
analysis
to
explore
associations
between
19
metabolism-related
lifestyle
clinical
risk
DSCs,
including
esophageal,
gastric,
colorectal,
hepatocellular,
biliary
tract,
pancreatic
cancer.
The
causal
association
was
explored
for
all
combinations
each
factor
DSC.
gathered
information
on
instrumental
variables
(IVs)
from
various
sources
retrieved
outcome
Biobank
Japan
(BBJ).
data
were
studies
east
Asian
populations.
Finally,
17,572
DSCs
cases
195,745
controls
included.
Our
found
that
genetically
predicted
alcohol
drinking
strong
indicator
gastric
cancer
(odds
ratio
(OR)
=
0.95;
95%
confidence
interval
(CI):
0.93-0.98)
hepatocellular
carcinoma
(OR
1.11;
CI:
1.05-1.18),
whereas
coffee
consumption
had
potential
protective
effect
0.69;
0.53-0.90).
Triglyceride
potentially
associated
with
decreased
tract
0.53;
0.34-0.81),
uric
acid
0.59;
0.37-0.96).
syndrome
(MetS)
esophageal
Additionally,
there
no
evidence
other
factors,
body
mass
index,
waist
circumference,
waist-to-hip
ratio,
educational
levels,
lipoprotein
cholesterol,
total
glycine,
creatinine,
gout,
Graves'
disease,
DSCs.
leave-one-out
revealed
single
nucleotide
polymorphism
(SNP)
rs671
ALDH2
gene
disproportionately
high
contribution
carcinoma,
as
well
carcinoma.
present
study
multiple
valuable
SNP
highlighting
significance
metabolic
both
prevention
treatment
