No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Neuron, Год журнала: 2021, Номер 109(14), С. 2239 - 2255

Опубликована: Май 19, 2021

Язык: Английский

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Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain

PLoS Biology, Год журнала: 2021, Номер 19(6), С. e3001275 - e3001275

Опубликована: Июнь 2, 2021

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified networks that interact with hippocampus-the default mode network (DMN) a "medial temporal network" (MTN) included regions in medial lobe (MTL) precuneus. We observed MTN plays critical role connecting visual to DMN hippocampus. The could be further divided into 3 subnetworks: "posterior medial" (PM) subnetwork comprised posterior cingulate lateral parietal cortices; an "anterior temporal" (AT) temporopolar dorsomedial prefrontal cortex; prefrontal" (MP) primarily cortex (mPFC). These vary their connectivity (FC) along hippocampal long axis represent different kinds information during memory-guided decision-making. Finally, Neurosynth meta-analysis fMRI studies suggests new hypotheses regarding functions subnetworks, providing framework guide future research neural architecture episodic memory.

Язык: Английский

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The Continuity of Context: A Role for the Hippocampus

Trends in Cognitive Sciences, Год журнала: 2021, Номер 25(3), С. 187 - 199

Опубликована: Янв. 12, 2021

Язык: Английский

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Allostasis as a core feature of hierarchical gradients in the human brain

Network Neuroscience, Год журнала: 2022, Номер 6(4), С. 1010 - 1031

Опубликована: Янв. 1, 2022

This paper integrates emerging evidence from two broad streams of scientific literature into one common framework: (a) hierarchical gradients functional connectivity that reflect the brain's large-scale structural architecture (e.g., a lamination gradient in cerebral cortex); and (b) approaches to predictive processing its specific instantiations called

Язык: Английский

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Adult Hippocampal Neurogenesis in the Human Brain: Updates, Challenges, and Perspectives

The Neuroscientist, Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

The existence of neurogenesis in the adult human hippocampus has been under considerable debate within past three decades due to diverging conclusions originating mostly from immunohistochemistry studies. While some these reports conclude that hippocampal humans occurs throughout physiologic aging, others indicate this phenomenon ends by early childhood. More recently, groups have adopted next-generation sequencing technologies characterize with more acuity extent humans. Here, we review current state research on brain an emphasis challenges and limitations using for its study.

Язык: Английский

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Zooming In and Out on One's Life: Autobiographical Representations at Multiple Time Scales

Journal of Cognitive Neuroscience, Год журнала: 2020, Номер 32(11), С. 2037 - 2055

Опубликована: Март 12, 2020

Abstract The ability to decouple from the present environment and explore other times is a central feature of human mind. Research in cognitive psychology neuroscience has shown that personal past future represented at multiple timescales levels resolution, broad lifetime periods span years short-time slices experience seconds. Here, I review this evidence propose theoretical framework for understanding mental time travel as capacity flexibly navigate hierarchical layers autobiographical representations. On view, thoughts rely on two main systems—event simulation knowledge—that allow us represent experiential contents are decoupled sensory input place these timeline scaffolded conceptual knowledge content structure our life. neural basis architecture discussed, emphasizing possible role medial pFC integrating representations service travel.

Язык: Английский

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The role of hippocampal mossy cells in novelty detection

Neurobiology of Learning and Memory, Год журнала: 2021, Номер 183, С. 107486 - 107486

Опубликована: Июнь 30, 2021

At the encounter with a novel environment, contextual memory formation is greatly enhanced, accompanied increased arousal and active exploration. Although this phenomenon has been widely observed in animal human daily life, how novelty environment detected contributes to lately started be unveiled. The hippocampus studied for many decades its largely known roles encoding spatial memory, growing body of evidence indicates differential involvement dorsal ventral hippocampal divisions detection. In brief review article, we discuss recent findings role mossy cells moiety detection put them perspective other novelty-related pathways hippocampus. We propose mechanism novelty-driven acquisition dentate gyrus by direct projection granule cells. By projection, sends signals hippocampus, opening gate based on information coming from entorhinal cortex. conclude that, contrary presently accepted functional independence, hippocampi cooperate link information, dorso-ventral interaction crucial novelty-dependent formation.

Язык: Английский

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Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation

Frontiers in Human Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Июнь 5, 2020

Neuroimaging evidence suggests that the development of hippocampus, a brain structure critical for memory function, contributes to improvements episodic between middle childhood adulthood. However, investigations on age differences in hippocampal activation and functional connectivity their contributions have yielded mixed results. Given known structural heterogeneity along long axis we investigated subregions with cross-sectional sample 96 participants ages 8-25 years. We found anterior posterior hippocampus supported formation, there was overall stability memory-related age. Without taking account outcome, direct contrast showed higher anterior, compared regions inferior frontal lateral temporal lobes, posterior, medial superior frontal, parietal, occipital lobes. A patterns identified region cortex, which differentially functionally connected. Finally, differential several visual/sensory cortices, underscoring importance examining connectivity. Moreover, specific indicate an increase specialization dynamic shift supports development.

Язык: Английский

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Age‐related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields

Hippocampus, Год журнала: 2020, Номер 31(1), С. 11 - 27

Опубликована: Сен. 12, 2020

Hippocampal circuit alterations that differentially affect hippocampal subfields are associated with age-related memory decline. Additionally, functional organization along the longitudinal axis of hippocampus has revealed distinctions between anterior and posterior (A-P) connectivity. Here, we examined connectivity (FC) differences young older adults at high-resolution within medial temporal lobe network (entorhinal, perirhinal, parahippocampal cortices), allowing us to explore how subfield across changes age. Overall, found reliably greater for younger than cortex (PHC) perirhinal (PRC). This drop in was more pronounced regions ones, consistent each subfields. Further, intra-hippocampal also reflected an decrease offset by increase Interestingly, anterior-posterior dysfunction PHC predictive lure discrimination performance on Mnemonic similarity task (MST), suggesting a role performance. While been well-documented, these results suggest may contribute significantly decline adults.

Язык: Английский

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Anterior–Posterior Hippocampal Dynamics Support Working Memory Processing

Journal of Neuroscience, Год журнала: 2021, Номер 42(3), С. 443 - 453

Опубликована: Ноя. 24, 2021

The hippocampus is a locus of working memory (WM) with anterior and posterior subregions that differ in their transcriptional external connectivity patterns. However, the involvement functional connections between these WM processing are poorly understood. To address issues, we recorded intracranial EEG from hippocampi humans (seven females seven males) who maintained set letters WM. We found maintenance was accompanied by elevated low-frequency activity both increased theta/alpha band (3–12 Hz) phase synchronization subregions. Cross-frequency Granger prediction analyses consistently showed correct trials were associated band-coordinated unidirectional influence to hippocampus. In contrast, errors bidirectional interactions These findings imply synchrony within may support successful via influence. A combination recording fine-grained atlas be value understanding neural mechanisms processing. SIGNIFICANCE STATEMENT Working crucial everyday functioning. has been proposed subcortical node involved processes. Previous studies have suggested patterns gene expression. it remains unknown whether how human hippocampal recruited coordinated during tasks. Here, electroencephalography simultaneously subregions, enhanced power areas them. Furthermore, hippocampus, whereas error correlated interactions. indicate long-axis specialization

Язык: Английский

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