Functional connectivity with the anterior and posterior hippocampus during spatial memory DOI
Haley A. Fritch, Dylan S. Spets, Scott D. Slotnick

et al.

Hippocampus, Journal Year: 2020, Volume and Issue: 31(7), P. 658 - 668

Published: Nov. 18, 2020

Evidence of differential connectivity and activity patterns across the long-axis hippocampus has led to many hypotheses about functional specialization anterior posterior hippocampus, including a hypothesis linking memory encoding retrieval. The hippocampal encoding/retrieval network (HERNET) model predicts that should engage attention network, whereas retrieval default network. In previous fMRI study employed multivoxel pattern analysis, we found in predicted quadrant spatial encoding. current study, investigated whether had higher degree or During phase, abstract shapes were presented each visual field participants instructed remember shape's location while maintaining central fixation. test same center screen identified shape. Generalized psychophysiological interaction analyses conducted between anatomically defined rest brain. This revealed preferential regions during addition, there location-specific with right items. These results suggest interact retrieval, respectively, support HERNET memory.

Language: Английский

No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory DOI Creative Commons
Asaf Gilboa, Morris Moscovitch

Neuron, Journal Year: 2021, Volume and Issue: 109(14), P. 2239 - 2255

Published: May 19, 2021

Language: Английский

Citations

130
Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain DOI Creative Commons
Alexander J. Barnett, Walter Reilly, Halle R. Dimsdale-Zucker

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(6), P. e3001275 - e3001275

Published: June 2, 2021

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified networks that interact with hippocampus-the default mode network (DMN) a "medial temporal network" (MTN) included regions in medial lobe (MTL) precuneus. We observed MTN plays critical role connecting visual to DMN hippocampus. The could be further divided into 3 subnetworks: "posterior medial" (PM) subnetwork comprised posterior cingulate lateral parietal cortices; an "anterior temporal" (AT) temporopolar dorsomedial prefrontal cortex; prefrontal" (MP) primarily cortex (mPFC). These vary their connectivity (FC) along hippocampal long axis represent different kinds information during memory-guided decision-making. Finally, Neurosynth meta-analysis fMRI studies suggests new hypotheses regarding functions subnetworks, providing framework guide future research neural architecture episodic memory.

Language: Английский

Citations

106
The Continuity of Context: A Role for the Hippocampus DOI
Andrew P. Maurer,

Lynn Nadel

Trends in Cognitive Sciences, Journal Year: 2021, Volume and Issue: 25(3), P. 187 - 199

Published: Jan. 12, 2021

Language: Английский

Citations

75
Allostasis as a core feature of hierarchical gradients in the human brain DOI Creative Commons
Yuta Katsumi, Jordan E. Theriault, Karen S. Quigley

et al.

Network Neuroscience, Journal Year: 2022, Volume and Issue: 6(4), P. 1010 - 1031

Published: Jan. 1, 2022

This paper integrates emerging evidence from two broad streams of scientific literature into one common framework: (a) hierarchical gradients functional connectivity that reflect the brain's large-scale structural architecture (e.g., a lamination gradient in cerebral cortex); and (b) approaches to predictive processing its specific instantiations called

Language: Английский

Citations

52
Adult Hippocampal Neurogenesis in the Human Brain: Updates, Challenges, and Perspectives DOI
Sophie Simard, Natalie Matosin, Naguib Mechawar

et al.

The Neuroscientist, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

The existence of neurogenesis in the adult human hippocampus has been under considerable debate within past three decades due to diverging conclusions originating mostly from immunohistochemistry studies. While some these reports conclude that hippocampal humans occurs throughout physiologic aging, others indicate this phenomenon ends by early childhood. More recently, groups have adopted next-generation sequencing technologies characterize with more acuity extent humans. Here, we review current state research on brain an emphasis challenges and limitations using for its study.

Language: Английский

Citations

9
Zooming In and Out on One's Life: Autobiographical Representations at Multiple Time Scales DOI
Arnaud D’Argembeau

Journal of Cognitive Neuroscience, Journal Year: 2020, Volume and Issue: 32(11), P. 2037 - 2055

Published: March 12, 2020

Abstract The ability to decouple from the present environment and explore other times is a central feature of human mind. Research in cognitive psychology neuroscience has shown that personal past future represented at multiple timescales levels resolution, broad lifetime periods span years short-time slices experience seconds. Here, I review this evidence propose theoretical framework for understanding mental time travel as capacity flexibly navigate hierarchical layers autobiographical representations. On view, thoughts rely on two main systems—event simulation knowledge—that allow us represent experiential contents are decoupled sensory input place these timeline scaffolded conceptual knowledge content structure our life. neural basis architecture discussed, emphasizing possible role medial pFC integrating representations service travel.

Language: Английский

Citations

70
Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation DOI Creative Commons
Lingfei Tang, Patrick Pruitt, Qijing Yu

et al.

Frontiers in Human Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: June 5, 2020

Neuroimaging evidence suggests that the development of hippocampus, a brain structure critical for memory function, contributes to improvements episodic between middle childhood adulthood. However, investigations on age differences in hippocampal activation and functional connectivity their contributions have yielded mixed results. Given known structural heterogeneity along long axis we investigated subregions with cross-sectional sample 96 participants ages 8-25 years. We found anterior posterior hippocampus supported formation, there was overall stability memory-related age. Without taking account outcome, direct contrast showed higher anterior, compared regions inferior frontal lateral temporal lobes, posterior, medial superior frontal, parietal, occipital lobes. A patterns identified region cortex, which differentially functionally connected. Finally, differential several visual/sensory cortices, underscoring importance examining connectivity. Moreover, specific indicate an increase specialization dynamic shift supports development.

Language: Английский

Citations

51
The role of hippocampal mossy cells in novelty detection DOI Creative Commons
Felipe Fredes, Ryuichi Shigemoto

Neurobiology of Learning and Memory, Journal Year: 2021, Volume and Issue: 183, P. 107486 - 107486

Published: June 30, 2021

At the encounter with a novel environment, contextual memory formation is greatly enhanced, accompanied increased arousal and active exploration. Although this phenomenon has been widely observed in animal human daily life, how novelty environment detected contributes to lately started be unveiled. The hippocampus studied for many decades its largely known roles encoding spatial memory, growing body of evidence indicates differential involvement dorsal ventral hippocampal divisions detection. In brief review article, we discuss recent findings role mossy cells moiety detection put them perspective other novelty-related pathways hippocampus. We propose mechanism novelty-driven acquisition dentate gyrus by direct projection granule cells. By projection, sends signals hippocampus, opening gate based on information coming from entorhinal cortex. conclude that, contrary presently accepted functional independence, hippocampi cooperate link information, dorso-ventral interaction crucial novelty-dependent formation.

Language: Английский

Citations

51
Anterior–Posterior Hippocampal Dynamics Support Working Memory Processing DOI Creative Commons
Jin Li, Dan Cao, Vasileios Dimakopoulos

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 42(3), P. 443 - 453

Published: Nov. 24, 2021

The hippocampus is a locus of working memory (WM) with anterior and posterior subregions that differ in their transcriptional external connectivity patterns. However, the involvement functional connections between these WM processing are poorly understood. To address issues, we recorded intracranial EEG from hippocampi humans (seven females seven males) who maintained set letters WM. We found maintenance was accompanied by elevated low-frequency activity both increased theta/alpha band (3–12 Hz) phase synchronization subregions. Cross-frequency Granger prediction analyses consistently showed correct trials were associated band-coordinated unidirectional influence to hippocampus. In contrast, errors bidirectional interactions These findings imply synchrony within may support successful via influence. A combination recording fine-grained atlas be value understanding neural mechanisms processing. SIGNIFICANCE STATEMENT Working crucial everyday functioning. has been proposed subcortical node involved processes. Previous studies have suggested patterns gene expression. it remains unknown whether how human hippocampal recruited coordinated during tasks. Here, electroencephalography simultaneously subregions, enhanced power areas them. Furthermore, hippocampus, whereas error correlated interactions. indicate long-axis specialization

Language: Английский

Citations

41
Age‐related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields DOI

Shauna M. Stark,

Amy Frithsen,

Craig E.L. Stark

et al.

Hippocampus, Journal Year: 2020, Volume and Issue: 31(1), P. 11 - 27

Published: Sept. 12, 2020

Hippocampal circuit alterations that differentially affect hippocampal subfields are associated with age-related memory decline. Additionally, functional organization along the longitudinal axis of hippocampus has revealed distinctions between anterior and posterior (A-P) connectivity. Here, we examined connectivity (FC) differences young older adults at high-resolution within medial temporal lobe network (entorhinal, perirhinal, parahippocampal cortices), allowing us to explore how subfield across changes age. Overall, found reliably greater for younger than cortex (PHC) perirhinal (PRC). This drop in was more pronounced regions ones, consistent each subfields. Further, intra-hippocampal also reflected an decrease offset by increase Interestingly, anterior-posterior dysfunction PHC predictive lure discrimination performance on Mnemonic similarity task (MST), suggesting a role performance. While been well-documented, these results suggest may contribute significantly decline adults.

Language: Английский

Citations

44