Neurological Sciences, Год журнала: 2024, Номер unknown
Опубликована: Дек. 6, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2360 - 2360
Опубликована: Фев. 17, 2024
This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological diseases, with a specific focus on Alzheimer's disease (AD), Parkinson's (PD), and stroke. The introduction highlights pivotal role neuroinflammation these disorders introduces unique properties AuNPs. review's core examines mechanisms by which AuNPs exert neuroprotection anti-neuro-inflammatory effects, elucidating various pathways through they manifest properties. potential therapeutic AD are discussed, shedding light promising avenues for therapy. also prospects utilizing PD interventions, presenting hopeful outlook future treatments. Additionally, delves into providing after strokes, emphasizing their significance mitigating cerebrovascular accidents' aftermath. Experimental findings from cellular animal models consolidated to provide comprehensive overview AuNPs' effectiveness, offering insights impact at both vivo levels. enhances our understanding diseases lays groundwork innovative strategies neurology.
Язык: Английский
Процитировано
24
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Янв. 22, 2025
Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.
Язык: Английский
Процитировано
2
Materials Today Chemistry, Год журнала: 2024, Номер 40, С. 102233 - 102233
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
13
Ibrain, Год журнала: 2023, Номер 9(3), С. 298 - 315
Опубликована: Авг. 14, 2023
Abstract Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide represent one of the major threats to human health. The prevalence these age‐dependent disorders is dramatically increasing over time, a process intrinsically related constantly rising percentage elderly population in recent years. Among all NDs, Alzheimer's Parkinson's are considered most debilitating as they cause memory cognitive loss, well severely affecting basic physiological conditions such ability move, speak, breathe. There an extreme need for new more effective therapies counteract devastating diseases, available treatments only able slow down pathogenic without really stopping or resolving it. This review aims elucidate current nanotechnology‐based tools representing future hope NDs treatment. Noble metal nano‐systems, that is, gold silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them deliver any pharmacological treatment way within central nervous system. can potentially make NPs reversing actual therapeutic strategy based slowing irreversible into permanent
Язык: Английский
Процитировано
14
Опубликована: Фев. 13, 2025
A problem of sufficiency the wide spread worldview about mechanism silver ion’s therapeutic action as its toxicity and destructivity for pathogens has been raised. Is such a always conjugated with direct destruction undesirable organisms bacteria, fungi cancer cells? Several works demonstrating stimulating preparations on viability, proliferation cells, behavioral, cognitive functions fertility laboratory animals well depletion induced inflammation have considered. The observed effects can not be explained from point view toxicity. mechanism, which is in eustress (positive stress) induction by ions exposed organism, suggested. confirmed experimental observations centuries successful experience use Medicine. However, realization distress (negative prevention significant attention should paid to form preparation, dose period exposure adaptive resources organism.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review article illustrates and discusses the application of metallic nanomaterials (MNMs) in detection treatment PD, as well theranostic MNMs.
Язык: Английский
Процитировано
0
AAPS PharmSciTech, Год журнала: 2024, Номер 25(7)
Опубликована: Сен. 5, 2024
Язык: Английский
Процитировано
2
Photochemistry and Photobiology, Год журнала: 2024, Номер 100(4), С. 980 - 988
Опубликована: Фев. 28, 2024
Developing multifunctional nanomaterials with distinct photochemical properties, such as high quantum yield, improved photostability, and good biocompatibility is critical for a wide range of biomedical applications. Motivated by this, we designed synthesized dansyl-tagged xanthate-based capping agent (DX) the synthesis fluorescent silver nanoparticles (AgNPs). The DX was characterized
Язык: Английский
Процитировано
1
Ibrain, Год журнала: 2024, Номер 10(2), С. 225 - 230
Опубликована: Май 9, 2024
Abstract Recent research has shown that tau protein can be passed to neighboring cells, leading cellular senescence in the endothelial cells present central nervous system (CNS). This discovery could potentially open new doors for testing novel therapeutic compounds specifically target senescent (senolytics) or identifying biomarkers enable early detection of tauopathies and dementia.
Язык: Английский
Процитировано
1
Ibrain, Год журнала: 2024, Номер 10(2), С. 123 - 133
Опубликована: Май 23, 2024
Abstract Neurodegenerative diseases represent an increasingly burdensome challenge of the past decade, primarily driven by global aging population. Ongoing efforts focus on implementing diverse strategies to mitigate adverse effects neurodegeneration, with goal decelerating pathology progression. Notably, in recent years, it has emerged that use nanoparticles (NPs), particularly those obtained through green chemical processes, could constitute a promising therapeutic approach. Green NPs, exclusively sourced from phytochemicals, are deemed safer compared NPs synthetized conventional route. In this study, chemistry‐derived silver (AgNPs) were assessed neuroblastoma cells, SHSY‐5Y, which considered pivotal model for investigating neurodegenerative diseases. Specifically, we used two different concentrations (0.5 and 1 µM) AgNPs time points (24 48 h) evaluate impact cells observing viability reduction intracellular calcium production, especially using µM at h. Furthermore, investigation atomic force microscopy (AFM) unveiled alteration Young's modulus due reorganization cortical actin following exposure AgNPs. This evidence was further corroborated confocal acquisitions as well coherency density analyses fibers. Our vitro findings suggest potential efficacy against neurodegeneration; therefore, vivo studies imperative optimize possible protocols.
Язык: Английский
Процитировано
1