Talanta, Год журнала: 2025, Номер 287, С. 127506 - 127506
Опубликована: Янв. 6, 2025
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.
Язык: Английский
Процитировано
19
Deleted Journal, Год журнала: 2024, Номер 2(2)
Опубликована: Март 4, 2024
Abstract As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These have enabled them be intensively used in the biomedical field recent years. To remedy lack of selectivity most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized integrate nanozymes produce various nanozyme–DNA combinations via adsorption/desorption. In formed combinations, DNA component provides molecular/ionic role, nanozyme part offers response catalytically amplified signals, enabling detect analytes biomarkers selectively sensitively. highlight this interesting topic, here we made a critical review interactions between their applications biosensing disease diagnosis. First, strategies for conjugation onto surface were introduced briefly. Then, summarized detail, where flexible modulations activity by adsorption/desorption as well factors analyzed, potential impacts caused on characteristics pointed out. After that, typical DNA‐mediated modulation toxic ion sensing, health risk factor monitoring, diagnosis introduced. end, prospects combination presented, future challenges also discussed, attract more interest effort advance promising area.
Язык: Английский
Процитировано
18
Biomaterials, Год журнала: 2025, Номер 319, С. 123179 - 123179
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
2
Analytica Chimica Acta, Год журнала: 2024, Номер 1303, С. 342477 - 342477
Опубликована: Март 22, 2024
Язык: Английский
Процитировано
14
Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(11)
Опубликована: Фев. 24, 2024
Abstract Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing role minimally invasive therapeutic delivery, tissue repair, regeneration. The recent emergence nanomaterials has ushered a revolutionary transformation the field, which demonstrates tremendous potential targeted therapies, biological imaging, disease diagnostics. Consequently, integration advanced nanotechnology promises to trigger new revolution realm hydrogels. HMs loaded combine advantages both hydrogels nanomaterials, enables multifaceted functionalities such as efficient drug sustained release, therapy, lubrication, biochemical detection, medical biosensing monitoring, micro‐robotics. Here, this review comprehensively expounds upon commonly used classifications. Then, it provides comprehensive insights into raw materials preparation methods HMs. Besides, common strategies employed achieve nano‐micron combinations are summarized, latest applications these combined field elucidated. Finally, valuable future design development provided.
Язык: Английский
Процитировано
11
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 177, С. 117815 - 117815
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
11
ACS Nano, Год журнала: 2024, Номер 18(34), С. 23672 - 23683
Опубликована: Авг. 13, 2024
Engineering Z-scheme heterojunctions represents a promising strategy for optimizing the separation and migration of charge carriers in semiconductor sonosensitizers enhanced reactive oxygen species (ROS) generation. Nevertheless, establishing continuous directional pathway ultrasonic-induced flow remains significant challenge. In this study, we present ternary Bi
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2024, Номер 11(23)
Опубликована: Апрель 1, 2024
Abstract Chiral nanomaterials with unique chiral configurations and biocompatible ligands have been booming over the past decade for their interesting chiroptical effect, catalytical activity, related bioapplications. The catalytic activity selectivity of emerged as important topics, that can be potentially controlled optimized by rational biochemical design nanomaterials. In this review, synthesis, composition, performances different biohybrid are discussed. construction multiscale geometries along underlying principles enhancing responses highlighted. Various approaches to regulate biocatalysis also summarized. Furthermore, attention is paid specific ligands, materials compositions, structure characteristics, so on introducing selective activities representative nanomaterials, emphasis substrates including small molecules, biological macromolecule, in‐site catalysis in living systems. Promising progress has emphasized featuring structural versatility improved gave rise unprecedented chances utilize light biocatalytic applications. summary, challenges, future trends, prospects associated comprehensively proposed.
Язык: Английский
Процитировано
10
Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(27), С. 5859 - 5870
Опубликована: Фев. 3, 2024
Язык: Английский
Процитировано
9
ACS Materials Letters, Год журнала: 2024, Номер 6(6), С. 2434 - 2445
Опубликована: Май 20, 2024
Oxidative stress and dysregulated inflammation lead to a detrimental loop in sepsis, which results cytokine storms multiorgan failure. Development of high-performance nanozyme impede the pathological cross-talk is an effective strategy. Herein, we develop multifunctional tannic acid-Zn-coated selenium nanoparticles (TZn@CSe) with superoxide dismutase glutathione peroxidase-like enzyme activities, can effectively neutralize various types ROS decrease expression iNOS. Furthermore, they reversed polarization M1 macrophages reduced inflammatory cytokines. Mechanistic assays revealed that TZn@CSe significantly modulated oxidative response signaling pathways, thereby alleviating storms. Eventually, increased survival rate septic mice by 50% ameliorated damage lungs, therapeutic efficacy surpassed first-line clinical drug. Our work provides feasible method for sepsis intercept interplay between inflammation.
Язык: Английский
Процитировано
9