Revista Pesquisa em Fisioterapia,
Год журнала:
2024,
Номер
14, С. e5416 - e5416
Опубликована: Апрель 25, 2024
INTRODUCTION:
Telerehabilitation
advanced
significantly
with
the
emergence
of
COVID-19
and
recommendation
limiting
physiotherapist-patient
contact
time
whenever
practicable.
The
effectiveness
telerehabilitation
on
those
who
had
a
longer
stay
in
hospital
oxygen
support
following
discharge
is
still
under
question.
OBJECTIVES:
To
evaluate
effects
after
six
weeks
pulmonary
exercise
tolerance,
fatigue
level,
perceived
exertion,
symptoms
depression
quality
life
patients
surviving
COVID-19.
MATERIALS
AND
METHODS:
A
quasi-experimental
study
was
conducted
25
post-COVID-19
home
environment
setting.
participants
were
advised
to
prepare
equipment
such
as
concentrator,
B-type
cylinder
(backup),
lengthy
tubes,
finger
pulse
oximeter,
mini
static
pedal
exerciser,
incentive
spirometry,
weight
cuffs
or
water
bottles
sandbags.
After
telerehabilitation,
underwent
assessments
including
initial
saturation
(SPO2),
heart
rate,
peak
demand
during
maintain
baseline
SPO2,
maximum
drop
recovery
SPO2
measured
oximeter
stopwatch,
exertion
using
Borg
Dyspnea
Scale,
score
visual
analog
scale
(VASF),
assessed
SF-36
questionnaire,
mental
health
status
evaluated
Hamilton
Depression
Scale
(HAMD).
One-way
repeated
measure
ANOVA
paired
t-test
used.
RESULTS:
Significant
improvements
intervention
(F
(2.12,
23.13)
=
21.0,
p<0.05)
rate
(1.839,
20.23)
43.73,
p<0.05),
(1.487,
16.36)
8.96,
(5,
55)
112.51,
(1.755,
19.30)
67.44,
(1.798,
19.78)
50.99,
(2.467,
27.14)
41.46,
achieve
78.89,
p<0.05).
Six-week
post-analysis
depressive
(mean
difference
=11.25,
p<
0.05)
also
showed
significant
improvement
=29.92,
0.05).
CONCLUSION:
Six
comprehensive
simple
improved
tolerance
exercise,
fatigue,
for
patients.
Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2213 - 2213
Опубликована: Авг. 7, 2023
This
systematic
review
and
meta-analysis
examines
how
pulmonary
rehabilitation
impacts
in
patients
suffering
from
subacute
long
COVID-19
infections,
gauging
enhancements
of
dyspnea,
physical
function,
quality
life,
psychological
state
(anxiety
depression),
fatigue.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 835 - 835
Опубликована: Июль 11, 2024
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID’s
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
Cells,
Год журнала:
2024,
Номер
13(6), С. 478 - 478
Опубликована: Март 8, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
persists
throughout
the
world
with
over
65
million
registered
cases
of
survivors
post-COVID-19
sequelae,
also
known
as
LongCOVID-19
(LongC).
LongC
exhibit
various
symptoms
that
span
multiple
organ
systems,
including
nervous
system.
To
search
for
neurological
markers
LongC,
we
investigated
soluble
biomolecules
present
in
plasma
and
proteins
associated
neuronal-enriched
extracellular
vesicles
(nEVs)
33
patients
impairment
(nLongC),
12
COVID-19
without
any
(Cov),
28
pre-COVID-19
healthy
controls
(HC).
positive
participants
were
infected
between
2020
2022,
not
hospitalized,
vaccinated
or
unvaccinated
before
infection.
IL-1β
was
significantly
increased
both
nLongC
Cov
IL-8
elevated
only
nLongC.
Both
brain-derived
neurotrophic
factor
cortisol
compared
to
HC.
nEVs
from
people
had
protein
neuronal
dysfunction,
amyloid
beta
42,
pTau181
TDP-43.
This
study
shows
chronic
peripheral
inflammation
stress
after
Additionally,
differentially
expressed
nEV
neurodegenerative
identified
recovering
regardless
persistent
symptoms.
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
persists
throughout
the
world
with
over
65
million
registered
cases
of
survivors
post-COVID-19
sequelae,
also
known
as
LongCOVID-19
(LongC).
LongC
exhibit
various
symptoms
that
span
multiple
organ
systems,
including
nervous
system.
To
search
for
neurological
biomarkers
LongC,
we
investigated
soluble
proteins
present
in
plasma
and
associated
neuronal-enriched
extracellular
vesicles
(nEVs)
33
patients
impairment
(nLongC),
12
COVID-19
without
any
(Cov),
28
pre-COVID-19
healthy
controls
(HC).
positive
participants
were
infected
from
2020-2022,
not
hospitalized,
vaccinated
or
unvaccinated
before
infection.
IL-1b
was
significantly
increased
both
nLongC
Cov
IL-8
elevated
only
nLongC.
Both
brain-derived
neurotropic
factor
cortisol
compared
to
HC.
nEVs
people
had
protein
markers
neuronal
dysfunction,
amyloid
beta
42,
pTau181
TDP-43.
This
study
shows
chronic
peripheral
inflammation
stress
after
Additionally,
differentially
expressed
nEV
neurodegenerative
identified
recovering
regardless
persistent
symptoms.
Journal of Cellular Biochemistry,
Год журнала:
2023,
Номер
124(10), С. 1466 - 1485
Опубликована: Окт. 1, 2023
Abstract
With
the
decline
in
number
of
new
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS‐CoV‐2)
infections,
World
Health
Organization
announced
end
SARS‐CoV‐2
pandemic.
However,
repercussions
this
viral
pandemic
may
remain
with
us
for
a
longer
period
time,
as
it
has
remodeled
lives
humankind
many
ways,
including
social
and
economic.
Of
course,
its
most
important
on
human
health
level.
Long‐coronavirus
disease
(COVID)
or
post‐COVID
is
state
which
we
do
not
have
concrete
definition,
specific
international
classification
diseases
Code,
clear
diagnostic
tools,
well‐known
effective
cures
yet.
In
second
article
from
Intrinsic
Factors
behind
long‐COVID
Series,
try
to
link
symptoms
their
causes,
starting
nervous
system.
Extracellular
vesicles
(ECVs)
play
very
complex
ramified
roles
bodies
both
healthy
not‐healthy
individuals.
ECVs
facilitate
entry
bioactive
molecules
pathogens
into
tissues
cells
system
across
blood–brain
barrier.
Based
size,
quantity,
quality
cargo,
are
directly
proportional
pathological
condition
severity
through
intertwined
mechanisms
that
evoke
inflammatory
immune
responses
typically
accompanied
by
over
variable
time
periods
according
type
these
symptoms.
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 126 - 126
Опубликована: Янв. 9, 2025
The
mechanisms
underlying
post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)
are
a
topic
debate.
This
study
examined
the
presence
microRNA
(miRNA)-like
small
RNAs
in
extracellular
fluids
and
their
potential
link
to
PASC
by
using
quantitative
stem-loop
RT-PCR
MiRNA
assay.
Initially,
it
was
demonstrated
that
three
previously
identified
miRNA-like
RNAs,
specifically
svRNA
1
2
miR-07a,
were
significantly
expressed
infected
cells
vitro
released
into
supernatant
following
different
variants.
Then,
expression
studied
both
nasopharyngeal
swabs
(NPS)
sera
from
24
patients
at
initial
COVID-19
diagnosis
(T0)
collected
91
193
days
post-diagnosis
(T1).
Notably,
11
out
(46%)
reported
consequences.
All
NPS
samples
showed
RNA
with
an
altered
cytokine
network
during
acute
infection,
but
did
not
correlate
outcomes.
Serum
had
similar
statuses,
though
patients,
notably
T1,
T0,
displayed
reduced
overall
positivity
compared
those
without
PASC.
host
target
between
groups.
suggests
need
for
further
research
its
role
viral
behavior
Journal of Cellular Biochemistry,
Год журнала:
2025,
Номер
126(5)
Опубликована: Май 1, 2025
The
efficient
transmission
of
SARS-CoV-2
caused
the
COVID-19
pandemic,
which
affected
millions
people
around
globe.
Despite
extensive
efforts,
specific
therapeutic
interventions
and
preventive
measures
against
its
consequences,
such
as
long
COVID,
have
not
yet
been
identified
due
to
lack
a
comprehensive
knowledge
biology.
Therefore,
deeper
understanding
sophisticated
strategies
employed
by
bypass
host
antiviral
defense
systems
is
needed.
One
these
inhibition
Ras
GTPase-activating
protein-binding
protein
(GAP
SH3-binding
or
G3BP)-dependent
immune
response
nucleocapsid
(N)
protein.
This
disrupts
formation
stress
granules
(SGs),
are
crucial
for
defense.
By
preventing
SG
formation,
virus
enhances
replication
evades
host's
response,
leading
increased
disease
severity.
Given
involvement
G3BP1
in
ability
interact
with
viral
proteins,
along
role
N
virus,
we
hypothesize
that
proteins
may
potential
pathogenesis
COVID.
current
direct
evidence
linking
their
interactions
functions
suggest
possible
connection
warrants
further
investigation.
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID's
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
