Efficacy of pulmonary telerehabilitation on exercise tolerance, fatigue, perceived exertion, depression, and quality of life in COVID-19 survivors DOI Creative Commons
Ramanathan Palaniappan Ramanathan, Sivaguru Muthusamy, Ambusam Subramaniam

et al.

Revista Pesquisa em Fisioterapia, Journal Year: 2024, Volume and Issue: 14, P. e5416 - e5416

Published: April 25, 2024

INTRODUCTION: Telerehabilitation advanced significantly with the emergence of COVID-19 and recommendation limiting physiotherapist-patient contact time whenever practicable. The effectiveness telerehabilitation on those who had a longer stay in hospital oxygen support following discharge is still under question. OBJECTIVES: To evaluate effects after six weeks pulmonary exercise tolerance, fatigue level, perceived exertion, symptoms depression quality life patients surviving COVID-19. MATERIALS AND METHODS: A quasi-experimental study was conducted 25 post-COVID-19 home environment setting. participants were advised to prepare equipment such as concentrator, B-type cylinder (backup), lengthy tubes, finger pulse oximeter, mini static pedal exerciser, incentive spirometry, weight cuffs or water bottles sandbags. After telerehabilitation, underwent assessments including initial saturation (SPO2), heart rate, peak demand during maintain baseline SPO2, maximum drop recovery SPO2 measured oximeter stopwatch, exertion using Borg Dyspnea Scale, score visual analog scale (VASF), assessed SF-36 questionnaire, mental health status evaluated Hamilton Depression Scale (HAMD). One-way repeated measure ANOVA paired t-test used. RESULTS: Significant improvements intervention (F (2.12, 23.13) = 21.0, p<0.05) rate (1.839, 20.23) 43.73, p<0.05), (1.487, 16.36) 8.96, (5, 55) 112.51, (1.755, 19.30) 67.44, (1.798, 19.78) 50.99, (2.467, 27.14) 41.46, achieve 78.89, p<0.05). Six-week post-analysis depressive (mean difference =11.25, p< 0.05) also showed significant improvement =29.92, 0.05). CONCLUSION: Six comprehensive simple improved tolerance exercise, fatigue, for patients.

Language: Английский

Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis DOI Creative Commons
Erika Meléndez‐Oliva, Oliver Martínez‐Pozas, Juan Nicolás Cuenca‐Zaldívar

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2213 - 2213

Published: Aug. 7, 2023

This systematic review and meta-analysis examines how pulmonary rehabilitation impacts in patients suffering from subacute long COVID-19 infections, gauging enhancements of dyspnea, physical function, quality life, psychological state (anxiety depression), fatigue.

Language: Английский

Citations

44
Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches DOI Creative Commons
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

11
Blood Markers Show Neural Consequences of LongCOVID-19 DOI Creative Commons
Norina Tang, Tatsuo Kido, Jian Shi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 478 - 478

Published: March 8, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC exhibit various symptoms that span multiple organ systems, including nervous system. To search for neurological markers LongC, we investigated soluble biomolecules present in plasma and proteins associated neuronal-enriched extracellular vesicles (nEVs) 33 patients impairment (nLongC), 12 COVID-19 without any (Cov), 28 pre-COVID-19 healthy controls (HC). positive participants were infected between 2020 2022, not hospitalized, vaccinated or unvaccinated before infection. IL-1β was significantly increased both nLongC Cov IL-8 elevated only nLongC. Both brain-derived neurotrophic factor cortisol compared to HC. nEVs from people had protein neuronal dysfunction, amyloid beta 42, pTau181 TDP-43. This study shows chronic peripheral inflammation stress after Additionally, differentially expressed nEV neurodegenerative identified recovering regardless persistent symptoms.

Language: Английский

Citations

9
Blood Biomarkers Show Neural Consequences of LongCOVID-19 DOI Open Access
Norina Tang, Tatsuo Kido, Jian Shi

et al.

Published: Feb. 16, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC exhibit various symptoms that span multiple organ systems, including nervous system. To search for neurological biomarkers LongC, we investigated soluble proteins present in plasma and associated neuronal-enriched extracellular vesicles (nEVs) 33 patients impairment (nLongC), 12 COVID-19 without any (Cov), 28 pre-COVID-19 healthy controls (HC). positive participants were infected from 2020-2022, not hospitalized, vaccinated or unvaccinated before infection. IL-1b was significantly increased both nLongC Cov IL-8 elevated only nLongC. Both brain-derived neurotropic factor cortisol compared to HC. nEVs people had protein markers neuronal dysfunction, amyloid beta 42, pTau181 TDP-43. This study shows chronic peripheral inflammation stress after Additionally, differentially expressed nEV neurodegenerative identified recovering regardless persistent symptoms.

Language: Английский

Citations

7
Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development DOI
Yousra A. El‐Maradny,

Moustafa A. Badawy,

Kareem I. Mohamed

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135201 - 135201

Published: Aug. 30, 2024

Language: Английский

Citations

5
Reduced Presence of SARS-CoV-2 microRNA-like Small RNA in the Serum of Patients with Post-Acute Sequelae SARS-CoV-2 Infection DOI Creative Commons
Maria Alfreda Stincarelli,

Isabella Abbate,

Giulia Matusali

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 126 - 126

Published: Jan. 9, 2025

The mechanisms underlying post-acute sequelae of SARS-CoV-2 infection (PASC) are a topic debate. This study examined the presence microRNA (miRNA)-like small RNAs in extracellular fluids and their potential link to PASC by using quantitative stem-loop RT-PCR MiRNA assay. Initially, it was demonstrated that three previously identified miRNA-like RNAs, specifically svRNA 1 2 miR-07a, were significantly expressed infected cells vitro released into supernatant following different variants. Then, expression studied both nasopharyngeal swabs (NPS) sera from 24 patients at initial COVID-19 diagnosis (T0) collected 91 193 days post-diagnosis (T1). Notably, 11 out (46%) reported consequences. All NPS samples showed RNA with an altered cytokine network during acute infection, but did not correlate outcomes. Serum had similar statuses, though patients, notably T1, T0, displayed reduced overall positivity compared those without PASC. host target between groups. suggests need for further research its role viral behavior

Language: Английский

Citations

0
Intrinsic factors behind long‐COVID: II. SARS‐CoV‐2, extracellular vesicles, and neurological disorders DOI
Yousra A. El‐Maradny, Alberto Rubio‐Casillas,

Kareem I. Mohamed

et al.

Journal of Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 124(10), P. 1466 - 1485

Published: Oct. 1, 2023

Abstract With the decline in number of new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infections, World Health Organization announced end SARS‐CoV‐2 pandemic. However, repercussions this viral pandemic may remain with us for a longer period time, as it has remodeled lives humankind many ways, including social and economic. Of course, its most important on human health level. Long‐coronavirus disease (COVID) or post‐COVID is state which we do not have concrete definition, specific international classification diseases Code, clear diagnostic tools, well‐known effective cures yet. In second article from Intrinsic Factors behind long‐COVID Series, try to link symptoms their causes, starting nervous system. Extracellular vesicles (ECVs) play very complex ramified roles bodies both healthy not‐healthy individuals. ECVs facilitate entry bioactive molecules pathogens into tissues cells system across blood–brain barrier. Based size, quantity, quality cargo, are directly proportional pathological condition severity through intertwined mechanisms that evoke inflammatory immune responses typically accompanied by over variable time periods according type these symptoms.

Language: Английский

Citations

10
Are the Comorbidities Constitute an Intrinsic Factor for Long COVID? DOI Open Access
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Published: May 2, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID&#039;s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

3
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions DOI
Altijana Hromić‐Jahjefendić, Lejla Mahmutović, Abas Sezer

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

3
Is There a Link between the Microbiome and Autoimmune Aspects of Long COVID-19? DOI Open Access
Altijana Hromić‐Jahjefendić, Lejla Mahmutović, Abas Sezer

et al.

Published: June 11, 2024

Long COVID-19 affects a significant percentage of survivors and is characterized by wide range symptoms, including weariness mental fog as well emotional symptoms like worry sadness. closely linked to the autoimmune disorders that are becoming more prevalent worldwide immune system hyperactivation, neutrophil extracellular trap (NET) development, molecular mimicry pathways. Long-term COVID-related responses include watchful system, altered innate adaptive cells, autoantigens secreted living or dead neutrophils, high concentrations autoantibodies directed against different proteins. The microbiome, which consists billions bacteria in human body, essential for controlling supporting overall health. microbiome can affect course long-term COVID-associated autoimmunity, degree illness, rate recovery, onset reactions. Although precise role long COVID autoimmunity still being investigated, new studies indicate probiotics, prebiotics, dietary changes—interventions target microbiome—may be able reduce reactions enhance outcomes survivors. It clear research required precisely understand how COVID-19-related create tailored treatment plans.

Language: Английский

Citations

1