Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline

Journal of Clinical Oncology, Год журнала: 2024, Номер 42(13), С. 1575 - 1593

Опубликована: Март 13, 2024

To guide clinicians, adults with cancer, caregivers, researchers, and oncology institutions on the medical use of cannabis cannabinoids, including synthetic cannabinoids herbal derivatives; single, purified cannabinoids; combinations ingredients; full-spectrum cannabis.

Язык: Английский

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Cannabis for Chronic Pain: Mechanistic Insights and Therapeutic Challenges

Stresses, Год журнала: 2025, Номер 5(1), С. 7 - 7

Опубликована: Янв. 15, 2025

Chronic pain represents a complex and debilitating condition that affects millions of people worldwide, significantly compromising their quality life. The conventional approach to treating this type often relies on the use opioid analgesics anti-inflammatory drugs. While these agents are effective in short term, they present several limitations, including risk dependence, severe side effects, and, some cases, ineffectiveness reducing pain. In context, medical cannabis has emerged as promising therapeutic alternative, given its potential ability relieve effectively with favorable safety profile. This work aims provide comprehensive up-to-date review existing literature effects treatment chronic Cannabis sativa contains pharmacologically active compounds, most prominent which delta-9-tetrahydrocannabinol (∆9-THC) cannabidiol (CBD), interact body’s endocannabinoid system, thereby modulating response. Clinical evidence shown cannabinoids can reduce intensity pain, particularly cases neuropathy, multiple sclerosis, arthritis, other painful conditions unresponsive treatments. However, full integration into clinical practice faces significant obstacles, need for standardized dosing, long-term data, regulatory frameworks. These issues, alongside concerns over adverse drug interactions, must be addressed unlock cannabinoids, patients, who endure both physical suffering added burden stress.

Язык: Английский

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The Resurgence of Synthetic Cannabinoid Receptor Agonists as Adulterants in the Era of Cannabis Legalization: Lessons from Prior Epidemics and Clinical Implications

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106043 - 106043

Опубликована: Фев. 1, 2025

Язык: Английский

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Efficacy of cannabinoids in neurodevelopmental and neuropsychiatric disorders among children and adolescents: a systematic review

European Child & Adolescent Psychiatry, Год журнала: 2023, Номер 33(2), С. 505 - 526

Опубликована: Март 3, 2023

A better understanding of the endocannabinoid system and a relaxation in regulatory control cannabis globally has increased interest medicinal use cannabinoid-based products (CBP). We provide systematic review rationale current clinical trial evidence for CBP treatment neuropsychiatric neurodevelopmental disorders children adolescents. search MEDLINE, Embase, PsycINFO, Cochrane Central Register Trials was performed to identify articles published after 1980 about medical purposes individuals aged 18 years or younger with selected conditions. Risk bias quality assessed each article. Of 4466 screened, were eligible inclusion, addressing eight conditions (anxiety (n = 1); autism spectrum disorder 5); foetal alcohol fragile X syndrome 2); intellectual disability mood post-traumatic stress 3); Tourette 3)). Only one randomised controlled (RCT) identified. The remaining seventeen included open-label trial, three uncontrolled before-and-after trials, two case series 11 reports, thus risk high. Despite growing community scientific interest, our identified limited generally poor-quality efficacy Large rigorous RCTs are required inform care. In meantime, clinicians must balance patient expectations available.

Язык: Английский

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New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions

Journal of Chemistry, Год журнала: 2023, Номер 2023, С. 1 - 36

Опубликована: Фев. 2, 2023

Across communities worldwide, various new psychoactive substances (NPSs) continue to emerge, which worsens the challenges global mental health, drug rules, and public health risks, as well combats their usage. Specifically, vast number of NPSs that are currently available, coupled with rate at ones emerge increasingly both forensic clinical testing strategies. The well-established NPS detection techniques include immunoassays, colorimetric tests, mass spectrometric techniques, chromatographic hyphenated types. Nonetheless, mitigating abuse usage is achievable through extensive community-based initiatives, increased focus on harm reduction. Clinically validated reliable from human samples, along community-driven solution, such reduction, will be great importance, especially in combating prevalence use other illicit synthetic substances. There a need for continued literature synthesis reiterate importance NPS, given continuous emergence recent years. All these discussed this overview, we performed another look into differentiating major groups identifying laboratory initiatives.

Язык: Английский

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The Association Between Past 12-Month Synthetic Cannabinoid Polysubstance Use and Cannabis Use Disorder in a Nationally Representative US Sample

International Journal of Mental Health and Addiction, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Язык: Английский

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Comprehensive Safety Assessment of Diverse Cannabinoids: A Scientific Inquiry

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 8, 2024

The surge in the popularity of cannabinoids has led to a proliferation companies catering demand for such products. As number suppliers rises, so does availability consumable cannabinoid While some products undergo testing meet acceptable standards, many opt minimal that overlooks uncommon contaminants potentially harmful during smoking or inhalation. unregulated market relies on reputable establish standards ensuring cleanliness Although numerous reports explore efficacy cannabinoids, safety remains less extensively documented. Misconceptions about recreational cannabis use and variations study methodologies, indications, dosing, administration protocols hinder overall assessment cannabinoid-based medicines. similarity retention times UV absorbance among adds complexity distinguishing isomers. Alternative techniques as LC/MS, GC/MS, NMR can aid characterizing cannabinoids. Our involved both high-purity from various companies, including crude distilled THC, HHC, THCP which are popular consumers. These tests were conducted against in-vitro lung cell lines simulate absorption these Considering nature markets presence high-quality low-quality products, our findings emphasize importance consumers prioritize clean remain competitive.

Язык: Английский

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Endocannabinoid-Binding Receptors as Drug Targets

Methods in molecular biology, Год журнала: 2022, Номер unknown, С. 67 - 94

Опубликована: Сен. 24, 2022

Язык: Английский

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Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential

Biomedicines, Год журнала: 2022, Номер 10(12), С. 3000 - 3000

Опубликована: Ноя. 22, 2022

Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by accumulation specific protein aggregates in brain. Such misfolded can trigger modulation innate adaptive immune systems subsequently lead to chronic neuroinflammation that drives onset progression diseases. Since there is still no effective disease-modifying treatment, new therapeutic targets for have been sought. The endocannabinoid system, particular cannabinoid CB2 receptors, extensively studied, due their important role neuroinflammation, especially microglial cells. Several studies shown promising effects receptor activation on reducing aggregation-based pathology as well attenuating inflammation several dementia-related symptoms. In this review, we discuss available data receptors potential benefits limitations agonists these therapy proteinopathies.

Язык: Английский

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Prevalence and Frequency of Cannabis Use Among Adults Ages 50–80 in the United States

Cannabis and Cannabinoid Research, Год журнала: 2023, Номер 9(1), С. 59 - 64

Опубликована: Ноя. 27, 2023

Introduction: Legal access to and attitudes toward cannabis are changing rapidly. Most of the United States territories allow adults use medical and/or recreational cannabis. Recent trends demonstrate increasing among older U.S. adults. However, little research has examined since 2019, when COVID-19 pandemic caused major changes in patterns substance use. Methods: The National Poll on Healthy Aging is a nationally cross-sectional survey that asked ages 50–80 January 2021 about their past year. Multivariable logistic regression was used identify demographic health characteristics associated with Results: Among 2023 participants aged (52.7% female), 12.1% reported those who use, 34.2% using products 4 or more days per week. In multivariable regression, less likely people identified as Hispanic ethnicity "other" races compared non-Hispanic white respondents. Cannabis unmarried/unpartnered unemployed Those consumed alcohol were Conclusions: More than one 10 1st year pandemic, many frequently. As continue increase nationally, clinicians policymakers should monitor address potential risks

Язык: Английский

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