Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2022,
Номер
20(3), С. 229 - 254
Опубликована: Ноя. 8, 2022
The
hunger
hormone,
ghrelin,
is
produced
not
only
in
response
to
food
deprivation,
but
also
released
during
various
types
of
stress.
In
recent
years,
the
rise
ghrelin
levels
has
come
be
seen
as
an
essential
component
stress
response.
review
devoted
ghrelin-dependent
mechanisms
providing
reciprocal
interaction
between
hypothalamuspituitaryadrenal
cortex
axis
and
dopaminergic
reward
system.
Direct
feedback
links
stress-realizing
system
paraventricular
nucleus,
neural
networks
lateral
hypothalamus
arcuate
nucleus
(which
form
centers
hunger/satiation),
mesolimbic
are
considered.
role
peripheral
satiety
hormones
glucocorticoids
regulation
motivation
reinforcement
discussed,
well
involvement
endogenous
opioid
endocannabinoid
receptors
learning
neurons
ventral
tegmental
area
hippocampus.
Pharmacological Reviews,
Год журнала:
2023,
Номер
75(5), С. 885 - 958
Опубликована: Май 10, 2023
The
cannabis
derivative
marijuana
is
the
most
widely
used
recreational
drug
in
Western
world
and
consumed
by
an
estimated
83
million
individuals
(∼3%
of
population).
In
recent
years,
there
has
been
a
marked
transformation
society
regarding
risk
perception
cannabis,
driven
its
legalization
medical
use
many
states
United
States
worldwide.
Compelling
research
evidence
Food
Drug
Administration
cannabis-derived
cannabidiol
approval
for
severe
childhood
epilepsy
have
confirmed
large
therapeutic
potential
itself,
Δ
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116473 - 116473
Опубликована: Март 24, 2024
The
elevation
of
endocannabinoid
levels
through
inhibiting
their
degradation
afforded
neuroprotection
in
CaMKIIα-TDP-43
mice,
a
conditional
transgenic
model
frontotemporal
dementia.
However,
which
cannabinoid
receptors
are
mediating
these
benefits
is
still
pending
to
be
elucidated.
We
have
investigated
the
involvement
CB1
and
CB2
receptor
using
chronic
treatments
with
selective
ligands
analysis
cognitive
deterioration
Novel
Object
Recognition
test,
immunostaining
for
neuronal
glial
markers
two
areas
interest
Our
results
confirmed
therapeutic
value
activating
either
or
receptor,
improvements
animal
performance
preservation
pyramidal
neurons,
particular
medial
prefrontal
cortex,
attenuation
reactivity,
hippocampus.
In
addition,
activation
both
reduced
elevated
TDP-43
cortex
an
effect
exerted
by
mechanisms
that
currently
under
investigation.
These
data
reinforce
notion
may
represent
promising
therapy
against
TDP-43-induced
neuropathology
Future
studies
will
confirm
benefits,
one
agonists
used
here,
has
been
thoroughly
characterized
clinical
development.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 19, 2024
Abstract
G
protein-coupled
receptor
55
(GPR55)
has
been
thought
to
be
a
putative
cannabinoid
receptor.
However,
little
is
known
about
its
functional
role
in
action
and
substance
use
disorders.
Here
we
report
that
GPR55
predominantly
found
glutamate
neurons
the
brain,
activation
reduces
self-administration
of
cocaine
nicotine
rats
mice.
Using
RNAscope
situ
hybridization,
mRNA
was
identified
cortical
vesicular
transporter
1
(VgluT1)-positive
subcortical
VgluT2-positive
neurons,
with
no
detection
midbrain
dopamine
(DA)
neurons.
Immunohistochemistry
detected
GPR55-like
signal
both
wildtype
GPR55-knockout
mice,
suggesting
non-specific
staining.
analysis
using
fluorescent
CB1/GPR55
ligand
(T1117)
CB1-knockout
mice
confirmed
binding
not
DA
Systemic
administration
agonist
O-1602
didnt
impact
∆
9
-THC-induced
analgesia,
hypothermia
catalepsy,
but
significantly
mitigated
cocaine-enhanced
brain-stimulation
reward
caused
by
optogenetic
alone
failed
alter
extracellar
DA,
elevated
extracellular
glutamate,
nucleus
accumbens.
In
addition,
also
demonstrated
inhibitory
effects
on
or
under
low
fixed-ratio
and/or
progressive-ratio
reinforcement
schedules
such
observed
Together,
these
findings
suggest
may
functionally
modulate
drug-taking
drug-seeking
behavior
possibly
via
glutamate-dependent
mechanism,
therefore,
deserves
further
study
as
new
therapeutic
target
for
treating
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2622 - 2622
Опубликована: Март 14, 2023
Lipids
are
usually
viewed
as
metabolic
fuel
and
structural
membrane
components.
Yet,
in
recent
years,
different
families
of
lipids
able
to
act
authentic
messengers
between
cells
and/or
intracellularly
have
been
discovered.
Such
lipid
signals
shown
exert
their
biological
activity
via
specific
receptors
that,
by
triggering
distinct
signal
transduction
pathways,
regulate
manifold
pathophysiological
processes
our
body.
Here,
endogenous
bioactive
produced
from
arachidonic
acid
(AA)
other
poly-unsaturated
fatty
acids
will
be
presented,
order
put
into
better
perspective
the
relevance
mutual
interactions
for
health
disease
conditions.
To
this
end,
metabolism
pathways
classical
eicosanoids,
endocannabinoids
specialized
pro-resolving
mediators
described,
intersections
commonalities
enzymes
binding
discussed.
Moreover,
AA-derived
with
such
shingosine-1-phosphate
steroid
hormones
addressed.
Veterinary Research Communications,
Год журнала:
2024,
Номер
48(5), С. 2915 - 2941
Опубликована: Авг. 20, 2024
Since
the
discovery
of
endocannabinoid
system
and
due
to
empirical
evidence
therapeutic
effects
on
several
illnesses
both
in
humans
animals
that
follow
administration
exogenous
cannabinoids
(i.e.,
phytocannabinoids),
numerous
studies
have
been
conducted.
These
investigations
aimed
identify
expression
distribution
cannabinoid
receptors
healthy
pathologic
organs
tissues
different
animal
species
define
interactions
phytocannabinoids
with
these
receptors.
In
last
decade,
pharmacokinetics,
efficacy
tolerability
many
Cannabis
derivatives
formulations,
mainly
containing
cannabidiol,
main
veterinary
interest,
also
investigated.
This
manuscript
summarizes
findings
reported
by
scientific
published
so
far
molecular
mode
action
phytocannabinoids,
localization
tissues,
as
well
dogs,
cats,
horses
other
interest.
A
deep
knowledge
issues
is
crucial
for
use
purposes
species.
Journal of Pain Research,
Год журнала:
2023,
Номер
Volume 16, С. 1533 - 1546
Опубликована: Май 1, 2023
Peripheral
nerve
block
is
often
used
to
relieve
postoperative
pain.
But
the
effect
of
on
inflammatory
response
not
fully
understood.
Spinal
cord
primary
center
pain
processing.
This
study
investigate
single
sciatic
spinal
in
rats
with
plantar
incision
and
combined
flurbiprofen.The
was
establish
a
model.
Single
block,
intravenous
flurbiprofen
or
combination
both
were
for
intervention.
The
sensory
motor
functions
after
evaluated.
changes
IL-1β,
IL-6,
TNF-α,
microglia
astrocytes
examined
by
qPCR
immunofluorescence
respectively.Sciatic
0.5%
ropivacaine
induced
2h
1.5h.
In
incision,
did
alleviate
inhibit
activation
astrocytes,
but
levels
IL-1β
IL-6
decreased
when
wore
off.
only
also
relieved
alleviated
astrocytes.The
cannot
improve
glial
cells,
can
reduce
expression
factors.
Nerve
inflammation
provides
reference
rational
clinical
application
block.
