Multiscale measurement of brain tissue and cell biomechanics using a mouse model

Biophysics Reports, Год журнала: 2025, Номер 11, С. 1 - 1

Опубликована: Янв. 1, 2025

Язык: Английский

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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

Biosensors, Год журнала: 2023, Номер 13(9), С. 880 - 880

Опубликована: Сен. 11, 2023

Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis treatment. To address the urgent need early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging excellent optical properties nanomaterials to enhance detection performance. These highly sensitive noninvasive biosensors offer opportunities biomarker-driven clinical diagnostics precision medicine. The highlights various types SERS-based targeting biomarkers, discussing their potential applications contributions diagnosis. Specific details about targeted biomarkers are provided. Furthermore, future research directions improving marker using SERS sensors outlined.

Язык: Английский

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Ultrasonic surface acoustic wave elastography: A review of basic theories, technical developments, and medical applications

Medical Physics, Год журнала: 2024, Номер 51(5), С. 3220 - 3244

Опубликована: Апрель 10, 2024

Physiological and pathological changes in tissues often cause tissue mechanical properties, making elastography an effective modality medical imaging. Among the existing methods, ultrasound is of great interest due to inherent advantages imaging technology, such as low cost, portability, safety, wide availability. However, most current methods are based on bulk shear wave; they can image deep but cannot superficial tissues. To address this challenge, ultrasonic surface acoustic waves have been proposed. In paper, we present a comprehensive review ultrasound-based wave techniques, including their theoretical foundations, technical implementations, applications. The goal provide concise summary state-of-the-art field, hoping offer reliable reference for further development these techniques foster expansion

Язык: Английский

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Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 18, 2024

Abstract Intracranial compliance (ICC) refers to the change in intracranial volume per unit pressure (ICP). Magnetic resonance elastography (MRE) quantifies brain stiffness by measuring shear modulus. Our objective is investigate relationship between ICC and through fluid–structure interaction (FSI) simulation, explore feasibility of using MRE assess based on stiffness. This invaluable due clinical importance ICC, as well fast non-invasive nature procedure. We employed FSI simulation hydrocephalus patients with aqueductal stenosis non-invasively calculate ICP which basis calculation FSI-based The simulated parameters used have been validated experimental data. results showed that there no simulated-based patients. However, MRE-based may be sensitive changes fluid dynamic such cerebral perfusion (CPP), blood flow (CBF), ICP, mechano-vascular brain, are determining assessment. Although optimism has found regarding assessment stiffness, especially for acute-onset disorders, further studies necessary clarify their direct relationship.

Язык: Английский

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Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis

Cerebral Cortex, Год журнала: 2023, Номер 34(1)

Опубликована: Дек. 7, 2023

Abstract Age at onset may be an important feature associated with distinct subtypes of amyotrophic lateral sclerosis (ALS). Little is known about the neuropathological mechanism early-onset ALS (EO-ALS) and late-onset (LO-ALS). Ninety patients were divided into EO-ALS LO-ALS group, 128 healthy controls matched young controls(YCs) old (OCs). A voxel-based morphometry approach was employed to investigate differences in gray matter volume (GMV). Significant age onset-by-diagnosis interactions found left parietal operculum, precentral gyrus, bilateral postcentral right occipital orbitofrontal cortex. Post hoc analysis revealed a significant decrease GMV all affected regions compared YCs, increased 5 6 brain regions, except for cortex, OCs. had significantly than after removing aging effect. Correspondingly, gyrus correlated disease severity 2 groups. Our findings suggested that pathological mechanisms different ages might differ. These provide unique insight clinical biological heterogeneity subtypes.

Язык: Английский

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Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(6)

Опубликована: Июнь 1, 2024

Abstract Background As physical signals, mechanical cues regulate the neural cells in brain. The mechanosensitive channels (MSCs) perceive and transduce them by permeating specific ions or molecules across plasma membrane, finally trigger a series of intracellular bioelectrical biochemical signals. Emerging evidence supports that wide‐distributed, high‐expressed MSCs like Piezo1 play important roles several neurophysiological processes neurological disorders. Aim s To systematically conclude functions brain provide novel mechanobiological perspective for diseases. Method We summarized detected research progress on functional physiological conditions. then concluded pathological activation downstream pathways triggered two categories diseases, neurodegenerative diseases place‐occupying damages. Finally, we outlined methods manipulating discussed their medical potential with some crucial outstanding issues. Results present underlying common mechanisms different acting as “transportation hubs” to distinct signal patterns: upstream pathways. Manipulating is feasible alter complicated processes, providing promising targets clinical treatment. Conclusions Recent provides insight into mediated inspire wide range therapeutic potentials targeted

Язык: Английский

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Indirect Shear Wave Excitation for Brain Magnetic Resonance Elastography With Minimal Cerebral Blood Flow Alteration

IEEE Transactions on Biomedical Engineering, Год журнала: 2024, Номер 71(9), С. 2590 - 2598

Опубликована: Март 26, 2024

Magnetic resonance elastography (MRE) of brain relies on inducing and measuring shear waves in the brain. However, studies have shown vibration could induce changes cerebral blood flow (CBF), which has a modulation effect can affect biomechanical properties measured.

Язык: Английский

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A Comprehensive Review on Viscoelastic Parameters Used for Engineering Materials Including Soft Materials and the Relationships between Different Damping Parameters

Опубликована: Авг. 14, 2024

The physical properties of a structure such stiffness although can be determined by some statical tests, the identification damping parameter requires dynamic test. In general, both theoretical prediction and experimental are quite difficult. There many different techniques available for identification, each method gives parameter. indentation method, rheometry, atomic force microscopy, resonant vibration tests commonly used to identify materials, including soft materials. While viscous ratio, loss factor, complex modulus viscosity common describe there also other parameters as specific capacity, angle, half-power bandwidth, logarithmic decrement various Often one these is measured in practical applications needs converted into another comparison purposes. this review, derivations description quantification their relationships, methods presented. expressions high low included evaluated. This paper could primary resource research teaching.

Язык: Английский

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A Comprehensive Review on the Viscoelastic Parameters Used for Engineering Materials, Including Soft Materials, and the Relationships between Different Damping Parameters

Sensors, Год журнала: 2024, Номер 24(18), С. 6137 - 6137

Опубликована: Сен. 23, 2024

Although the physical properties of a structure, such as stiffness, can be determined using some statical tests, identification damping parameters requires dynamic test. In general, both theoretical prediction and experimental are quite difficult. There many different techniques available for identification, each method gives parameter. The indentation method, rheometry, atomic force microscopy, resonant vibration tests commonly used to identify materials, including soft materials. While viscous ratio, loss factor, complex modulus, viscosity common describe there also other parameters, specific capacity, angle, half-power bandwidth, logarithmic decrement, various Often, one these is measured, measured parameter needs converted into another comparison purposes. this review, derivations description quantification their relationships presented. expressions high low included evaluated. This study considered first comprehensive review article presenting large number among with quantitative evaluation accurate approximate formulas. paper could primary resource research teaching.

Язык: Английский

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Hippocampus of the APPNL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Июль 20, 2023

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy cortical hippocampal brain structures are classic hallmarks Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture AD occur alongside changes in mechanical properties tissue, as reported recent magnetic resonance elastography (MRE) measurements human mechanics. Whilst MRE has many advantages, a significant shortcoming is its spatial resolution. Higher resolution “cellular scale” assessment alterations regions involved memory formation, such hippocampus, could provide fresh new insight into etiology AD. Characterization tissue mechanics at cellular length scale first stepping-stone understanding how mechanosensitive neurons glia impacted by neurodegenerative disease-associated their microenvironment. To microscale aging we measured spatiotemporal hippocampus using high atomic force microscopy (AFM) indentation tests on acute slices from young aged wild-type mice APP NL–G–F mouse model. Several significantly softer than age-matched wild-types, notably dentate granule cell layer CA1 pyramidal layer. Interestingly, regional softening coincides with an increase astrocyte reactivity, suggesting that amyloid pathology-mediated may impact function astrocytes. Our data also raise questions whether aberrant mechanotransduction signaling susceptibility stressors

Язык: Английский

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