Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(23), С. 16010 - 16010

Опубликована: Ноя. 30, 2022

Although many studies of long COVID-19 were reported, there was a lack systematic research which assessed the differences in regard to what unique SARS-CoV-2 strains caused it. As such, this review and meta-analysis aims evaluate characteristics that is by different strains. We systematically searched PubMed, EMBASE, ScienceDirect databases order find cohort as defined WHO (Geneva, Switzerland). The main outcomes determining percentages among patients who infected with Further, study registered PROSPERO (CRD42022339964). A total 51 33,573 included, three possessed Alpha Delta variants, five Omicron variant. highest pooled estimate found CT abnormalities (60.5%; 95% CI: 40.4%, 80.6%) for wild-type strain; fatigue (66.1%; 42.2%, 89.9%) variant; ≥1 general symptoms (28.4%; 7.9%, 49.0%) estimates (65.8%; 47.7%, 83.9%) variant, followed strain, then myalgia variant (11.7%; 95%: 8.3%, 15.1%), compared those strain (9.4%; 6.3%, 12.5%). sleep difficulty lowest (2.5%; 0.2%, 4.9%) when (24.5%; 17.5%, 31.5%) (18.7%; 1.0%, 36.5%). findings suggest no significant difference between has been strains, except certain (i.e., or variant) strain). In context ongoing pandemic its emerging directing more attention well implementing targeted intervention measures address it are vital.

Язык: Английский

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SARS-CoV-2 incubation period across variants of concern, individual factors, and circumstances of infection in France: a case series analysis from the ComCor study

The Lancet Microbe, Год журнала: 2023, Номер 4(6), С. e409 - e417

Опубликована: Апрель 18, 2023

Язык: Английский

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T cell immune memory after covid-19 and vaccination

BMJ Medicine, Год журнала: 2023, Номер 2(1), С. e000468 - e000468

Опубликована: Ноя. 1, 2023

The T cell memory response is a crucial component of adaptive immunity responsible for limiting or preventing viral reinfection. after infection with the SARS-CoV-2 virus vaccination broad, and spans multiple proteins epitopes, about 20 in each individual. So far long lasting provides high level cross reactivity hence resistance to escape by variants virus, such as omicron variant. All current vaccine regimens tested produce robust responses, heterologous will probably enhance protective responses through increased breadth. could have major role protecting against severe covid-19 disease rapid clearance early presentation presence reactive cells might this protection. likely provide ongoing protection admission hospital death, development pan-coronovirus future proof new pandemic strains.

Язык: Английский

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Outcomes of Elderly Patients Hospitalized with the SARS-CoV-2 Omicron B.1.1.529 Variant: A Systematic Review

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(3), С. 2150 - 2150

Опубликована: Янв. 25, 2023

The Omicron (B.1.1.529) variant of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) had an increased rate spreading among general population. Although this virus mutation resulted in milder symptoms, those on vulnerable side population are still danger developing symptoms. Thus, systematic review focused identifying clinical outcomes older age patients (>65) that hospitalized with SARS-CoV-2 variant. research was conducted using four electronic databases (PubMed, Scopus, Web Science, and ProQuest Central), a search query December 2022 comprised duration COVID-19 pandemic. inclusion criteria (1) than 65 years, (2) history hospitalization for infection, (3) infection B.1.1.529 initial generated 295 articles, out which six were included review, total 7398 patients. main findings when looking at elderly population, mortality rates remained high. This is because people more have comorbidities interfere virus’s progress. However, there inconsistency rates, since data reported by studies different selection based severity infection. no statistically significant differences found between unvaccinated vaccinated groups, who got booster doses vaccination lower likelihood serving as protective factor

Язык: Английский

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Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

SUMMARY The long-term effects of repeated COVID-19 vaccinations on adaptive immunity remain incompletely understood. Here, we conducted a comprehensive three-year longitudinal study examining T cell and antibody responses in 78 vaccinated individuals without reported symptomatic infections. We observed distinct dynamics Spike-specific humoral cellular immune across multiple vaccine doses. While titers incrementally increased stabilized with each booster, rapidly plateaued, maintaining remarkable stability CD4+ CD8+ subsets. Notably, approximately 30% participants showed reactivity to non-Spike antigens, consistent asymptomatic Single-cell RNA sequencing revealed diverse landscape phenotypes, no evidence exhaustion or significant functional impairment. However, qualitative changes were infection, exhibiting unique immunological characteristics, including frequencies Th17-like cells GZMKhi/IFNR Remarkably, this group associated progressive increase regulatory cells, potentially indicating balanced response that may mitigate immunopathology. By regularly stimulating memory, boosters contribute stable enhanced response, which provide better protection against

Язык: Английский

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A phenome‐wide investigation of risk factors for severe COVID‐19

Journal of Medical Virology, Год журнала: 2022, Номер 95(1)

Опубликована: Ноя. 1, 2022

With the continued spread of COVID-19 globally, it is crucial to identify potential risk or protective factors associated with COVID-19. Here, we performed genetic correlation analysis and Mendelian randomization examine relationships between hospitalization 405 health conditions lifestyle in 456 422 participants from UK Biobank. The revealed 134 positive 65 negative correlations, including those intakes a variety dietary components. MR indicates that set body fat-related traits, maternal smoking around birth, basal metabolic rate, lymphocyte count, peripheral enthesopathies allied syndromes, blood clots leg, arthropathy are causal for severe COVID-19, while higher education attainment, physical activity, asthma, never status protect against illness. Our findings have implications stratification patients prevention its outcomes.

Язык: Английский

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Smart Thermometer–Based Participatory Surveillance to Discern the Role of Children in Household Viral Transmission During the COVID-19 Pandemic

JAMA Network Open, Год журнала: 2023, Номер 6(6), С. e2316190 - e2316190

Опубликована: Июнь 1, 2023

Importance Children’s role in spreading virus during the COVID-19 pandemic is yet to be elucidated, and measuring household transmission traditionally requires contact tracing. Objective To discern children’s viral when enveloped viruses were at historic lows predominance of illnesses attributed COVID-19. Design, Setting, Participants This cohort study a voluntary US tracked data from participatory surveillance using commercially available thermometers with companion smartphone app October 2019 2022. Eligible participants individuals temperature measurements households multiple members between 2022 who opted into sharing. Main Outcomes Measures Proportion transmissions pediatric index case changes school breaks assessed thermometer data. Results A total 862 577 320 073 (462 000 female [53.6%] 463 368 adults [53.7%]) included. The number febrile episodes forecast new cases. Within-household was inferred 54 506 (15.4%) increased fourth period, March July 2021 (3263 32 294 [10.1%]) Omicron BA.1/BA.2 wave (16 516 94 316 [17.5%]; P < .001). Among 38 787 166 170 children, median (IQR) 70.4% (61.4%-77.6%) had case; proportions fluctuated weekly 36.9% 84.6%. 0.6 0.8 times less frequent typical breaks. winter break decrease 68.4% (95% CI, 57.1%-77.8%) 41.7% 34.3%-49.5%) end 2020 ( At beginning 2022, it dropped 80.3% 75.1%-84.6%) 54.5% 51.3%-57.7%) During summer breaks, rates 81.4% 74.0%-87.1%) 62.5% 56.3%-68.3%) by August = .02) 83.8% 79.2%-87.5) 62.8% 57.1%-68.1%) These patterns persisted over 2 years. Conclusions Relevance In this measure within-household national scale, we discerned an important for children spread infection within pandemic, heightened schools session, supporting attendance spread.

Язык: Английский

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Assessment of vaccinations and breakthrough infections after adjustment of the dynamic zero-COVID-19 strategy in China: an online survey

Emerging Microbes & Infections, Год журнала: 2023, Номер 12(2)

Опубликована: Сен. 11, 2023

Coronavirus disease 2019 (COVID-19) cases in China has grown rapidly after adjustment of the dynamic zero-COVID-19 strategy. However, how different vaccination states affect symptoms, severity and post COVID conditions was unclear. Here, we used an online questionnaire to investigate infection status severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among 11,897 participants, with 55.55% positive 28.42% negative. The common COVID-19 symptoms were fatigue (73.31%), cough (70.02%), fever (65.25%) overall soreness (58.64%); self-reported asymptomatic accounted for 0.7% participants. persistent at 1 month included (48.7%), drowsiness (34.3%), (30.1%), decreased exercise ability (23.1%) pharyngeal discomfort (19.4%), which reduced by more than 200% months. Participants complications such as chronic obstructive pulmonary disease, diseases, diabetes, hypertension, etc. have a higher proportion hospitalization longer recovery time (

Язык: Английский

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Mathematical Assessment of the Role of Human Behavior Changes on SARS-CoV-2 Transmission Dynamics in the United States

Bulletin of Mathematical Biology, Год журнала: 2024, Номер 86(8)

Опубликована: Июнь 18, 2024

Язык: Английский

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Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape

Human Vaccines & Immunotherapeutics, Год журнала: 2023, Номер 19(1)

Опубликована: Янв. 2, 2023

Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, as variants concern (VoCs), such omicron associated sub-variants, emerge, boosting strategies must also adapt keep pace with changing landscape. Heterologous vaccination regimens involving administration booster vaccines different than primary series practical, effective, safe continue reduce global burden disease 2019 (COVID-19). To understand immunogenicity, effectiveness, safety heterologous mRNA-based strategies, relevant clinical real-world observational studies were identified summarized. Overall, that are currently available those in will play an important role protecting individuals from COVID-19 caused by emerging VoCs.

Язык: Английский

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