Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(16), С. 1362 - 1376
Опубликована: Апрель 27, 2024
Abstract::
Although
immunotherapy
and
targeted
therapy
have
radically
changed
melanoma
treatment,
the
development
of
resistance
reduction
patient
responses
are
still
significant
problems.
Small
molecule
inhibitors
needed
to
overcome
this
situation,
biomarkers
that
can
estimate
whether
patients
will
reply
existing
treatments
need
be
developed.
miRNAs
involved
in
diverse
processes
such
as
tumor
development,
progression,
metastasis,
invasion.
While
some
act
suppressors,
others
may
oncogenic.
also
contribute
drug
resistance.
There
is
increasing
evidence
demonstrating
possible
effect
on
diagnosis
treatment
markers
melanoma.
The
manuscript
focuses
current
challenges
highlighting
issues
reduced
despite
revolutionary
advancements
immunotherapy.
It
underscores
for
small
creation
predicting
treatments.
role
invasion
has
been
highlighted.
certain
function
exhibit
oncogenic
properties.
Furthermore,
presented
potential
significance
symptom
identification
These
findings
indicate
a
promising
avenue
future
research
clinical
applications.
In
summary,
article
effectively
communicates
key
insights,
making
it
valuable
resource
those
interested
treatment.
Cells,
Год журнала:
2023,
Номер
12(1), С. 184 - 184
Опубликована: Янв. 2, 2023
Immune
cells
and
commensal
microbes
in
the
human
intestine
constantly
communicate
with
react
to
each
other
a
stable
environment
order
maintain
healthy
immune
activities.
system-microbiota
cross-talk
relies
on
complex
network
of
pathways
that
sustain
balance
between
tolerance
immunogenicity.
Probiotic
bacteria
can
interact
stimulate
intestinal
microflora
modulate
specific
functions
homeostasis.
Growing
evidence
shows
probiotic
present
important
health-promoting
immunomodulatory
properties.
Thus,
use
probiotics
might
represent
promising
approach
for
improving
system
So
far,
few
studies
have
been
reported
beneficial
modulatory
effect
probiotics.
However,
many
others,
which
are
mainly
focused
their
metabolic/nutritional
properties,
published.
Therefore,
mechanisms
behind
interaction
host
only
partially
described.
The
review
aims
collect
summarize
most
recent
scientific
results
resulting
implications
how
improve
functions.
Hence,
description
currently
known
is
provided.
Theranostics,
Год журнала:
2023,
Номер
14(1), С. 143 - 158
Опубликована: Ноя. 15, 2023
Human
osteogenic
differentiation
is
a
complex
and
well-orchestrated
process
which
involves
plethora
of
molecular
players
cellular
processes.A
growing
number
studies
have
underlined
that
circular
RNAs
(circRNAs)
play
an
important
regulatory
role
during
human
differentiation.CircRNAs
are
single-stranded,
covalently
closed
non-coding
RNA
molecules
acquiring
increased
attention
as
epigenetic
regulators
gene
expression.Given
their
intrinsic
high
conformational
stability,
abundance,
specificity,
circRNAs
can
undertake
various
biological
activities
in
order
to
regulate
multiple
processes,
including
differentiation.The
most
recent
evidence
indicates
control
osteogenesis
by
preventing
the
inhibitory
activity
miRNAs
on
downstream
target
genes,
using
competitive
endogenous
mechanism.The
aim
this
review
draw
currently
known
mechanisms
differentiation.Specifically,
we
provide
understanding
advances
research
conducted
mesenchymal
stem
cell
types
importance
regulating
osteogenesis.A
comprehensive
underlying
circRNA
will
improve
knowledge
processes
bone
growth,
resulting
potential
development
novel
preclinical
clinical
discovery
diagnostic
therapeutic
tools
for
disorders.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115242 - 115242
Опубликована: Июль 31, 2023
Bladder
cancer
(BC)
is
a
common
and
serious
type
of
that
ranks
among
the
top
ten
most
prevalent
malignancies
worldwide.
Due
to
high
occurrence
rate
BC,
aggressive
nature
cells,
their
resistance
medication,
managing
this
disease
has
become
growing
challenge
in
clinical
care.
Long
noncoding
RNAs
(lncRNAs)
are
group
RNA
transcripts
do
not
code
for
proteins
more
than
200
nucleotides
length.
They
play
significant
role
controlling
cellular
pathways
molecular
interactions
during
onset,
development
progression
different
types
cancers.
Recent
advancements
high-throughput
gene
sequencing
technology
have
led
identification
various
differentially
expressed
lncRNAs
which
indicate
abnormal
expression.
In
review,
we
summarize
these
been
found
impact
several
functions
related
including
proliferation,
cell
growth,
migration,
metastasis,
apoptosis,
epithelial-mesenchymal
transition,
chemo-
radio-resistance.
Additionally,
may
improve
prognosis
prediction
BC
patients,
indicating
future
use
them
as
prognostic
diagnostic
biomarkers
patients.
This
review
highlights
genetic
tools
anti-tumor
agents,
such
CRISPR/Cas
systems,
siRNA,
shRNA,
antisense
oligonucleotides,
vectors,
created
preclinical
models.
interest
using
based
on
positive
research
findings.
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(7)
Опубликована: Июль 1, 2023
Limited
molecular
knowledge
of
Merkel
cell
polyomavirus
(MCPyV)-positive
and
-negative
carcinoma
(MCC)
subsets
(MCCP/MCCN)
has
prevented
so
far
the
identification
MCC
origin
type
and,
therefore,
development
effective
therapies.
The
retinoic
gene
signature
was
investigated
in
various
MCCP,
MCCN,
control
fibroblast/epithelial
lines
to
elucidate
heterogeneous
nature
MCC.
Hierarchical
clustering
principal
component
analysis
indicated
that
MCCP
MCCN
cells
were
clusterizable
from
each
other
cells,
according
their
signature.
versus
differentially
expressed
genes
(n
=
43)
identified.
Protein-protein
interaction
network
SOX2,
ISL1,
PAX6,
FGF8,
ASCL1,
OLIG2,
SHH,
GLI1
as
upregulated
hub
JAG1
MYC
downregulated
compared
MCCN.
Numerous
MCCP-associated
DNA-binding/-transcription
factors
involved
neurological
stemness.
Enrichment
analyses
predominantly
encode
for
development,
stemness,
invasiveness,
cancer.
Our
findings
suggest
neuroendocrine
by
which
neuronal
precursor
could
undergo
an
MCPyV-driven
transformation.
These
overarching
results
might
open
way
novel
retinoid-based
Annals of Translational Medicine,
Год журнала:
2023,
Номер
11(2), С. 119 - 119
Опубликована: Янв. 1, 2023
Growth
arrest-specific
5
(GAS5)
is
a
long
noncoding
RNA
(lncRNA)
that
regulates
cell
viability.
GAS5
lncRNA
has
been
shown
to
decrease
colorectal
and
breast
cancer
carcinogenesis.
Although
the
function
mechanisms
related
in
development
of
ovarian
(OC)
remains
unclear.
The
goal
this
study
was
clarify
essential
functions
regulating
OC
progression
its
underlying
mechanism.Relative
levels
normal
tissues
were
identified
by
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR).
regulatory
effects
on
proliferation
apoptosis
SK-OV-3
cells
evaluated.
Moreover,
bioinformatics
tools
used
predict
novel
target
[microRNA
(miRNA)]
GAS5.
To
explore
key
GAS5/miRNA-23a/WT1
loop
mediating
progression,
we
performed
functional
experiments
dual-luciferase
reporter
(DLR)
gene
assessment.Downregulation
found
OC,
which
positively
correlated
with
poor
prognosis.
In
addition,
lower
expression
accelerated
migration
demonstrated
percentage
vitro
experiments.
It
acts
as
molecular
sponge
for
miR-23a
cells.
Additionally,
WT1
detected
cells,
through
sponging
miR-23a,
regulated
expression.
Rescue
tests
enhancing
outputs
miR-23a-WT1
axis
reversed
impacts
silencing
OC.The
GAS5/miR-23a/WT1
cascade
participate
OC.
also
decreases
upregulating
attenuating
suggesting
it
could
be
an
advantageous
therapeutic
intervention.
Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2024,
Номер
38(7), С. 1419 - 1431
Опубликована: Март 7, 2024
Abstract
Background
The
limited
therapies
available
for
treating
Merkel
cell
carcinoma
(MCC),
a
highly
aggressive
skin
neoplasm,
still
pose
clinical
challenges,
and
novel
treatments
are
required.
Targeting
retinoid
signalling
with
retinoids,
such
as
all‐
trans
retinoic
acid
(ATRA),
is
promising
clinically
useful
antitumor
approach.
ATRA
drives
tumour
differentiation
by
modulating
signalling,
leading
to
anti‐proliferative
pro‐apoptotic
effects.
Although
dysregulated
in
MCC,
activity
this
unknown.
This
study
aimed
evaluate
the
impact
of
on
pathological
phenotype
MCC
cells.
Methods
effect
was
tested
various
polyomavirus‐positive
polyomavirus‐negative
lines
terms
proliferation,
viability,
migration
clonogenic
abilities.
In
addition,
cycle,
apoptosis/cell
death
gene
signature
were
evaluated
upon
treatments.
Results
efficiently
impaired
proliferation
viability
A
strong
reducing
clonogenicity
determined
ATRA‐treated
Moreover,
resulted
strongly
effective
arresting
cycle
inducing
all
Enrichment
analyses
indicated
that
cells
promote
pathways,
which
led
pro‐apoptotic/cell
Conclusions
These
results
underline
potential
retinoid‐based
therapy
management
might
open
way
experimental
approaches
other
retinoids
and/or
combinatorial
