A New Approach to Melanoma Treatment: microRNAs DOI
Süleyman İlhan, Ferdi Oğuz, Harika Atmaca

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(16), P. 1362 - 1376

Published: April 27, 2024

Abstract:: Although immunotherapy and targeted therapy have radically changed melanoma treatment, the development of resistance reduction patient responses are still significant problems. Small molecule inhibitors needed to overcome this situation, biomarkers that can estimate whether patients will reply existing treatments need be developed. miRNAs involved in diverse processes such as tumor development, progression, metastasis, invasion. While some act suppressors, others may oncogenic. also contribute drug resistance. There is increasing evidence demonstrating possible effect on diagnosis treatment markers melanoma. The manuscript focuses current challenges highlighting issues reduced despite revolutionary advancements immunotherapy. It underscores for small creation predicting treatments. role invasion has been highlighted. certain function exhibit oncogenic properties. Furthermore, presented potential significance symptom identification These findings indicate a promising avenue future research clinical applications. In summary, article effectively communicates key insights, making it valuable resource those interested treatment.

Language: Английский

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health DOI Creative Commons
Chiara Mazziotta, Mauro Tognon, Fernanda Martini

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(1), P. 184 - 184

Published: Jan. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Language: Английский

Citations

365
Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation DOI Creative Commons
Chiara Mazziotta, Giada Badiale,

Christian Felice Cervellera

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 14(1), P. 143 - 158

Published: Nov. 15, 2023

Human osteogenic differentiation is a complex and well-orchestrated process which involves plethora of molecular players cellular processes.A growing number studies have underlined that circular RNAs (circRNAs) play an important regulatory role during human differentiation.CircRNAs are single-stranded, covalently closed non-coding RNA molecules acquiring increased attention as epigenetic regulators gene expression.Given their intrinsic high conformational stability, abundance, specificity, circRNAs can undertake various biological activities in order to regulate multiple processes, including differentiation.The most recent evidence indicates control osteogenesis by preventing the inhibitory activity miRNAs on downstream target genes, using competitive endogenous mechanism.The aim this review draw currently known mechanisms differentiation.Specifically, we provide understanding advances research conducted mesenchymal stem cell types importance regulating osteogenesis.A comprehensive underlying circRNA will improve knowledge processes bone growth, resulting potential development novel preclinical clinical discovery diagnostic therapeutic tools for disorders.

Language: Английский

Citations

32
Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies DOI Open Access

Amirreza Mehmandar‐Oskuie,

Kasra Jahankhani,

Arman Rostamlou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115242 - 115242

Published: July 31, 2023

Bladder cancer (BC) is a common and serious type of that ranks among the top ten most prevalent malignancies worldwide. Due to high occurrence rate BC, aggressive nature cells, their resistance medication, managing this disease has become growing challenge in clinical care. Long noncoding RNAs (lncRNAs) are group RNA transcripts do not code for proteins more than 200 nucleotides length. They play significant role controlling cellular pathways molecular interactions during onset, development progression different types cancers. Recent advancements high-throughput gene sequencing technology have led identification various differentially expressed lncRNAs which indicate abnormal expression. In review, we summarize these been found impact several functions related including proliferation, cell growth, migration, metastasis, apoptosis, epithelial-mesenchymal transition, chemo- radio-resistance. Additionally, may improve prognosis prediction BC patients, indicating future use them as prognostic diagnostic biomarkers patients. This review highlights genetic tools anti-tumor agents, such CRISPR/Cas systems, siRNA, shRNA, antisense oligonucleotides, vectors, created preclinical models. interest using based on positive research findings.

Language: Английский

Citations

28
The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk DOI

Nehal I. Rizk,

Heba M. Midan,

Gouda K. Helal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154771 - 154771

Published: Aug. 19, 2023

Language: Английский

Citations

24
Potential therapeutic strategy for cancer: Multi-dimensional cross-talk between circRNAs and parental genes DOI
Xiaoyu Sun, Xinyi Zhao, Yan Xu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216794 - 216794

Published: March 6, 2024

Language: Английский

Citations

8
miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma DOI
Tohada M. AL‐Noshokaty, Mohammed S. Elballal,

Gouda K. Helal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154763 - 154763

Published: Aug. 14, 2023

Language: Английский

Citations

21
Distinct retinoic gene signatures discriminate Merkel cell polyomavirus‐positive from ‐negative Merkel cell carcinoma cells DOI Creative Commons
Chiara Mazziotta,

Christian Felice Cervellera,

Giada Badiale

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(7)

Published: July 1, 2023

Limited molecular knowledge of Merkel cell polyomavirus (MCPyV)-positive and -negative carcinoma (MCC) subsets (MCCP/MCCN) has prevented so far the identification MCC origin type and, therefore, development effective therapies. The retinoic gene signature was investigated in various MCCP, MCCN, control fibroblast/epithelial lines to elucidate heterogeneous nature MCC. Hierarchical clustering principal component analysis indicated that MCCP MCCN cells were clusterizable from each other cells, according their signature. versus differentially expressed genes (n = 43) identified. Protein-protein interaction network SOX2, ISL1, PAX6, FGF8, ASCL1, OLIG2, SHH, GLI1 as upregulated hub JAG1 MYC downregulated compared MCCN. Numerous MCCP-associated DNA-binding/-transcription factors involved neurological stemness. Enrichment analyses predominantly encode for development, stemness, invasiveness, cancer. Our findings suggest neuroendocrine by which neuronal precursor could undergo an MCPyV-driven transformation. These overarching results might open way novel retinoid-based

Language: Английский

Citations

15
lncRNA GAS5 suppression of the malignant phenotype of ovarian cancer via the miR-23a-WT1 axis DOI Open Access
Li Zhou, Hongye Jiang, Lin Lin

et al.

Annals of Translational Medicine, Journal Year: 2023, Volume and Issue: 11(2), P. 119 - 119

Published: Jan. 1, 2023

Growth arrest-specific 5 (GAS5) is a long noncoding RNA (lncRNA) that regulates cell viability. GAS5 lncRNA has been shown to decrease colorectal and breast cancer carcinogenesis. Although the function mechanisms related in development of ovarian (OC) remains unclear. The goal this study was clarify essential functions regulating OC progression its underlying mechanism.Relative levels normal tissues were identified by quantitative real-time polymerase chain reaction (qRT-PCR). regulatory effects on proliferation apoptosis SK-OV-3 cells evaluated. Moreover, bioinformatics tools used predict novel target [microRNA (miRNA)] GAS5. To explore key GAS5/miRNA-23a/WT1 loop mediating progression, we performed functional experiments dual-luciferase reporter (DLR) gene assessment.Downregulation found OC, which positively correlated with poor prognosis. In addition, lower expression accelerated migration demonstrated percentage vitro experiments. It acts as molecular sponge for miR-23a cells. Additionally, WT1 detected cells, through sponging miR-23a, regulated expression. Rescue tests enhancing outputs miR-23a-WT1 axis reversed impacts silencing OC.The GAS5/miR-23a/WT1 cascade participate OC. also decreases upregulating attenuating suggesting it could be an advantageous therapeutic intervention.

Language: Английский

Citations

13
All‐trans retinoic acid exhibits anti‐proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation DOI
Chiara Mazziotta, Giada Badiale,

Christian Felice Cervellera

et al.

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(7), P. 1419 - 1431

Published: March 7, 2024

Abstract Background The limited therapies available for treating Merkel cell carcinoma (MCC), a highly aggressive skin neoplasm, still pose clinical challenges, and novel treatments are required. Targeting retinoid signalling with retinoids, such as all‐ trans retinoic acid (ATRA), is promising clinically useful antitumor approach. ATRA drives tumour differentiation by modulating signalling, leading to anti‐proliferative pro‐apoptotic effects. Although dysregulated in MCC, activity this unknown. This study aimed evaluate the impact of on pathological phenotype MCC cells. Methods effect was tested various polyomavirus‐positive polyomavirus‐negative lines terms proliferation, viability, migration clonogenic abilities. In addition, cycle, apoptosis/cell death gene signature were evaluated upon treatments. Results efficiently impaired proliferation viability A strong reducing clonogenicity determined ATRA‐treated Moreover, resulted strongly effective arresting cycle inducing all Enrichment analyses indicated that cells promote pathways, which led pro‐apoptotic/cell Conclusions These results underline potential retinoid‐based therapy management might open way experimental approaches other retinoids and/or combinatorial

Language: Английский

Citations

5
Epigenetics and environmental health DOI
Min Zhang, Ting Hu,

Tianyu Ma

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(4), P. 571 - 596

Published: May 28, 2024

Language: Английский

Citations

5