Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102233 - 102233

Опубликована: Фев. 14, 2024

Язык: Английский

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New insight on the possible role of statins in Vascular Parkinsonism: A need for presumptive therapy

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102209 - 102209

Опубликована: Янв. 28, 2024

Язык: Английский

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The possible role of cerebrolysin in the management of vascular dementia: Leveraging concepts

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Metformin role in Parkinson’s disease: a double-sword effect

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(4), С. 975 - 991

Опубликована: Июнь 2, 2023

Язык: Английский

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The beneficial role of autophagy in multiple sclerosis: Yes or No?

Autophagy, Год журнала: 2023, Номер 20(2), С. 259 - 274

Опубликована: Сен. 15, 2023

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against

Язык: Английский

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A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson’s disease: beneficial or detrimental effects

Inflammopharmacology, Год журнала: 2023, Номер 31(2), С. 673 - 688

Опубликована: Март 24, 2023

Язык: Английский

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The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads

Molecular Neurobiology, Год журнала: 2023, Номер 61(5), С. 2469 - 2480

Опубликована: Окт. 28, 2023

Язык: Английский

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BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(10)

Опубликована: Май 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Язык: Английский

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Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Март 27, 2024

Abstract Parkinson's disease (PD) is a progressive neurodegenerative as result of the degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc). The fundamental features PD are motor and non-motor symptoms. symptoms develop due to disruption neurotransmitters other such γ-aminobutyric acid (GABA). potential role GABA neuropathology concerning was not precisely discussed. Therefore, this review intended illustrate possible regarding pathway essential regulating inhibitory tone prevent excessive stimulation cerebral cortex. Degeneration linked with reducing GABAergic neurotransmission. Decreasing activity promotes mitochondrial dysfunction oxidative stress, which highly related neuropathology. Hence, restoring by agonists may attenuate progression dysregulation SNpc contributes developing Besides, also pathway, amelioration reduce In conclusion, deregulation might be intricate Improving novel, beneficial approach control

Язык: Английский

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Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration

Cells, Год журнала: 2024, Номер 13(2), С. 123 - 123

Опубликована: Янв. 9, 2024

The COVID-19 pandemic has brought to the forefront intricate relationship between SARS-CoV-2 and its impact on neurological complications, including potential links neurodegenerative processes, characterized by a dysfunction of protein quality control systems ER stress. This review article explores role systems, such as Unfolded Protein Response (UPR), Endoplasmic Reticulum-Associated Degradation (ERAD), Ubiquitin–Proteasome System (UPS), autophagy molecular chaperones, in infection. Our hypothesis suggests that produces stress exploits leading disruption proteostasis cannot be solved host cell. culminates cell death may represent link neurodegeneration.

Язык: Английский

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