Macromolecular Bioscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Abstract
Self‐assembling
peptide‐based
materials
with
ordered
nanostructures
possess
advantages
such
as
good
biocompatibility
and
biodegradability,
superior
controllability,
ease
of
chemical
modification.
Through
covalent
conjugation
or
non‐covalent
encapsulation,
photosensitizers
(PSs)
can
be
carried
by
self‐assembling
nanomaterials
for
targeted
delivery
towards
tumor
tissues.
This
improves
the
stability,
solubility,
accumulation
PSs,
well
reduces
their
dark
toxicity.
More
importantly,
these
tailored
responsiveness
to
microenvironment,
which
enables
smart
release
PSs
precise
enhanced
photodynamic
therapy
(PDT).
In
this
review,
self‐assembly
peptide
from
perspective
driving
forces
is
first
described,
various
zero
3D
are
subsequently
highlighted
PDT
cancers
in
recent
years.
Finally,
an
outlook
field
provided
motivate
fabrication
advanced
nanomaterials.
Cellulose,
Год журнала:
2024,
Номер
31(6), С. 3353 - 3376
Опубликована: Март 15, 2024
Abstract
Cellulose
has
been
intensively
investigated
for
biomedical
applications,
because
of
its
excellent
properties,
like
biodegradability,
biocompatibility,
abundant
availability
renewable
resources
and
cost-effectiveness.
Among
all
sources
cellulose,
marine
macroalgae
or
seaweeds,
are
acquiring
tremendous
attention,
due
to
their
high
around
the
world.
Moreover,
atypical
proliferation
some
exotic
species
represents
a
serious
problem
ecosystems,
since
accumulation
threatens
native
oceanic
worldwide.
Several
studies
already
reported
successfully
extraction
cellulose
derivatives
from
brown,
green
red
macroalgae.
The
extracted
properties
vary
according
type
algae,
maturity
used
methods.
This
review
will
cover
main
methods
extract
focusing
on
more
sustainable
ones,
as
well
further
processing
into
various
derivatives.
Electrospun
nanofibers
have
revealed
great
potential
such
delivery
therapeutic
agents,
tissue
engineering,
wound
dressings
enzyme
immobilization.
Pure
presents
drawbacks,
limited
solubility
in
organic
solvents
inability
fuse
inter
intra-molecular
hydrogen
bonding.
To
overcome
these
limitations,
derivatives,
which
includes
microcrystalline
nanocrystals,
nanofibers,
acetate
carboxymethyl
extensively
studied
generate
electrospun
fibers.
Therefore,
this
aims
explore
seaweeds
promising
source
methodologies
compounds,
demonstrate
developed
by
electrospinning
with
algae-based
applications.
Abstract
The
properties
of
materials
play
a
significant
role
in
triboelectric
nanogenerators
(TENGs).
Advanced
for
TENGs
have
attracted
tremendous
attention
because
their
superior
advantages
(e.g.,
high
specific
surface
area,
porosity,
and
customizable
macrostructure).
These
advanced
can
be
extensively
applied
numerous
fields,
including
energy
harvester,
wearable
electronics,
filtration,
self‐powered
sensors.
Hence,
designing
as
functional
is
important
the
development
TENGs.
Herein,
structural
modification
methods
based
on
electrospinning
to
improve
latest
research
progress
this
kind
are
systematically
summarized.
Preparation
design
trends
nanofibers,
microspheres,
hierarchical
structures,
doping
nanomaterials
highlighted.
factors
influencing
formation
considered.
Furthermore,
applications
elaborated.
Finally,
challenges
discussed,
thereby
guiding
researchers
large‐scale
application
Molecules,
Год журнала:
2023,
Номер
28(7), С. 3053 - 3053
Опубликована: Март 29, 2023
Cancer
remains
one
of
the
most
challenging
health
problems
worldwide,
and
localized
therapeutic
approaches
based
on
micro/nanofibers
have
shown
potential
for
its
treatment.
Micro/nanofibers
offer
several
advantages
as
a
drug
delivery
system,
such
high
surface
area,
tunable
pore
size,
sustained
release
properties,
which
can
improve
efficacy
reduce
side
effects.
In
addition,
functionalization
these
fibers
with
nanoparticles
enhance
their
targeting
capabilities.
Localized
drugs
and/or
other
agents
via
also
help
to
overcome
limitations
systemic
administration,
poor
bioavailability
off-target
Several
studies
promising
results
in
preclinical
models
cancer,
including
inhibition
tumor
growth
improved
survival
rates.
However,
more
research
is
needed
technical
regulatory
challenges
bring
clinical
use.
hold
great
promise
future
cancer
treatment,
providing
targeted,
effective,
minimally
invasive
alternative
traditional
treatments.
The
main
focus
this
review
explore
current
treatments
utilizing
micro/nanofibers,
well
systems
that
rely
fibrous
structures
deliver
treatment
specific
area.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 1017 - 1017
Опубликована: Июль 31, 2024
Over
the
last
decade,
scientists
have
shifted
their
focus
to
development
of
smart
carriers
for
delivery
chemotherapeutics
in
order
overcome
problems
associated
with
traditional
chemotherapy,
such
as
poor
aqueous
solubility
and
bioavailability,
low
selectivity
targeting
specificity,
off-target
drug
side
effects,
damage
surrounding
healthy
tissues.
Nanofiber-based
systems
recently
emerged
a
promising
system
cancer
therapy
owing
unique
structural
functional
properties,
including
tunable
interconnected
porosity,
high
surface-to-volume
ratio
entrapment
efficiency
loading
capacity,
mass
transport
which
allow
controlled
targeted
delivery.
In
addition,
they
are
biocompatible,
biodegradable,
capable
surface
functionalization,
allowing
target-specific
release.
One
most
common
fiber
production
methods
is
electrospinning,
even
though
relatively
two-dimensional
(2D)
tightly
packed
structures
rates
limited
its
performance.
Forcespinning
an
alternative
spinning
technology
that
generates
high-throughput,
continuous
polymeric
nanofibers
3D
structures.
Unlike
forcespinning
fibers
by
centrifugal
forces
rather
than
electrostatic
forces,
resulting
significantly
higher
production.
The
functionalization
nanocarriers
on
can
result
anticancer
capabilities
be
activated
external
stimuli,
light.
This
review
addresses
current
trends
potential
applications
light-responsive
dual-stimuli-responsive
electro-
forcespun
therapy,
particular
emphasis
functionalizing
nanofiber
surfaces
developing
nano-in-nanofiber
emerging
dual-controlled
release
high-precision
tumor
targeting.
progress
prospective
diagnostic
therapeutic
discussed
context
combination
therapy.
