Colloids and Interfaces,
Год журнала:
2024,
Номер
8(3), С. 35 - 35
Опубликована: Июнь 2, 2024
Amphiphilic
silk
fibroin
(SF)
forms
stable
adsorption
layers
at
the
air–water
interface.
The
range
of
investigated
protein
concentrations
can
be
divided
into
two
parts
according
to
peculiarities
surface
layer
properties.
At
from
0.0005
0.01
mg/mL,
dynamic
elasticity
monotonically
increases
with
concentration
and
age
reaches
values
up
220
mN/m.
In
this
range,
compression
leads
a
fast
increase
pressure.
second
part
(>0.01
mg/mL),
decreases
again
kinetic
dependences
film
thickness
adsorbed
amount
change
only
little.
case,
slight
These
types
behavior
attributed
distinctions
in
aggregation
layer.
Atomic
force
microscopy
(AFM)
investigations
transferred
liquid
onto
mica
by
Langmuir–Schaefer
method
show
some
morphology
intermediate
(~0.02
mg/mL).
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1829 - 1829
Опубликована: Июнь 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
Bioengineering,
Год журнала:
2024,
Номер
11(2), С. 167 - 167
Опубликована: Фев. 9, 2024
The
golden
rule
in
tissue
engineering
is
the
creation
of
a
synthetic
device
that
simulates
native
tissue,
thus
leading
to
proper
restoration
its
anatomical
and
functional
integrity,
avoiding
limitations
related
approaches
based
on
autografts
allografts.
emergence
biocompatible
materials
has
led
production
innovative
scaffolds
that,
if
combined
with
cells
and/or
bioactive
molecules,
can
improve
regeneration.
In
last
decade,
silk
fibroin
(SF)
gained
attention
as
promising
biomaterial
regenerative
medicine
due
enhanced
bio/cytocompatibility,
chemical
stability,
mechanical
properties.
Moreover,
possibility
produce
advanced
medical
tools
such
films,
fibers,
hydrogels,
3D
porous
scaffolds,
non-woven
particles
or
composite
from
raw
aqueous
solution
emphasizes
versatility
SF.
Such
devices
are
capable
meeting
most
diverse
needs;
hence,
they
represent
an
clinical
for
treatment
bone/cartilage,
cardiovascular
system,
neural,
skin,
pancreatic
regeneration,
well
many
other
biomedical
applications.
present
narrative
review
encompasses
topics
(i)
interesting
features
SF-based
biomaterials,
bare
SF’s
biological
nature
structural
features,
comprehending
chemo-physical
properties
techniques
used
desired
formulations
SF;
(ii)
different
applications
biomaterials
their
structures,
discussing
biocompatibility
effectiveness
field.
Particularly,
also
analyzed
herein
highlight
therapeutic
strategies
applied
various
body
sectors.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 25, 2024
Silk
fibroin
is
an
important
natural
fibrous
protein
with
excellent
prospects
for
tissue
engineering
applications.
With
profound
studies
in
recent
years,
its
potential
repair
has
been
developed.
A
growing
body
of
literature
investigated
various
fabricating
methods
silk
and
their
application
repair.
The
purpose
this
paper
to
trace
the
latest
developments
SF-based
scaffolds
engineering.
In
review,
we
first
presented
primary
secondary
structures
fibroin.
processing
SF
were
then
summarized.
Lastly,
examined
contribution
new
applying
as
regeneration
Overall,
review
showed
progress
fabrication
utilization
fibroin-based
scaffolds.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(28)
Опубликована: Июль 15, 2024
3D
in
vitro
model
has
emerged
as
a
valuable
tool
for
studying
tissue
development,
drug
screening,
and
disease
modeling.
systems
can
accurately
replicate
microstructures
physiological
features,
mirroring
the
vivo
microenvironment
departing
from
conventional
2D
cell
cultures.
Various
models
utilizing
biomacromolecules
like
collagen
synthetic
polymers
have
been
developed
to
meet
diverse
research
needs
address
complex
challenges
of
contemporary
research.
Silk
proteins,
bearing
structural
functional
similarities
collagen,
increasingly
employed
construct
advanced
systems,
surpassing
limitations
This
review
examines
silk
proteins'
composition,
structure,
properties,
functions,
elucidating
their
role
models.
Furthermore,
recent
advances
biomedical
applications
involving
silk-based
organoid
are
discussed.
In
particular,
unique
attributes
matrix
constituents
constructs
highlighted,
providing
meticulous
evaluation
importance.
Additionally,
it
outlines
current
hurdles
complexities
while
contemplating
future
avenues,
thereby
paving
way
developing
biomimetic
protein-based
microtissues.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(8), С. 233 - 233
Опубликована: Авг. 20, 2024
Advanced
periodontitis
poses
a
significant
threat
to
oral
health,
causing
extensive
damage
and
loss
of
both
hard
soft
periodontal
tissues.
While
traditional
therapies
such
as
scaling
root
planing
can
effectively
halt
the
disease’s
progression,
they
often
fail
fully
restore
original
architecture
function
tissues
due
limited
capacity
for
spontaneous
regeneration.
To
address
this
challenge,
tissue
engineering
has
emerged
promising
approach.
This
technology
centers
on
utilization
biomaterial
scaffolds,
which
three-dimensional
(3D)
templates
or
frameworks,
supporting
guiding
regeneration
tissues,
including
ligament,
cementum,
alveolar
bone,
gingival
tissue.
These
scaffolds
mimic
extracellular
matrix
(ECM)
native
aiming
foster
cell
attachment,
proliferation,
differentiation,
and,
ultimately,
formation
new,
functional
structures.
Despite
inherent
challenges
associated
with
preclinical
testing,
intensification
research
coupled
continuous
advancement
fabrication
technology,
leads
us
anticipate
expansion
in
their
application
review
comprehensively
covers
recent
advancements
engineered
specifically
regeneration,
provide
insights
into
current
state
field
potential
directions
future
research.
