Fabrication and Evaluation of Dissolving Hyaluronic Acid Microneedle Patches for Minimally Invasive Transdermal Drug Delivery by Nanoimprinting
Gels,
Год журнала:
2025,
Номер
11(2), С. 89 - 89
Опубликована: Янв. 23, 2025
Transdermal
drug
delivery
minimizes
pain
and
provides
a
controlled,
stable
release
of
drugs,
but
its
effectiveness
is
limited
by
the
skin’s
natural
barriers.
Microneedles
overcome
this
problem,
enabling
minimally
invasive
delivery.
Microneedle
patches
(MNPs)
with
80
µm-tall
needles
composed
hyaluronic
acid
(HA)
were
developed
evaluated
for
their
formability,
structural
integrity,
dissolution
rate,
skin
penetration
ability,
transmission
capacity.
The
influence
molecular
weight
HA
on
these
properties
was
also
investigated.
MNPs
made
from
low-molecular-weight
(30
kDa–50
kDa)
demonstrated
12.5
times
superior
permeability
in
ex
vivo
human
compared
to
needleless
(NLPs).
Furthermore,
same
test,
had
1.7
higher
than
high-molecular-weight
MNPs,
suggesting
transdermal
administration.
significantly
influenced
solubility
permeability,
highlighting
potential
as
systems.
Puncture
tests
depth
50–60
µm,
indicating
minimal
nerve
irritation
dermis
effective
superficial
dermal
layer.
These
results
present
manufacturing
technique
incorporating
model
compounds
highlight
novel
method
biomedical
applications
soft
gels.
Язык: Английский
Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101739 - 101739
Опубликована: Апрель 1, 2025
Diabetic
wounds
(DW)
represent
a
significant
clinical
challenge
due
to
chronic
inflammation,
excessive
oxidative
stress,
and
impaired
angiogenesis,
all
of
which
hinder
effective
tissue
regeneration.
Existing
drug
delivery
systems
often
fail
achieve
sustained
targeted
therapeutic
efficacy.
In
this
study,
we
developed
novel
dissolvable
dual-layer
methacrylated
gelatin
(GelMA)
microneedle
(MN)
co-loading
selenium-doped
carbon
quantum
dots
(Se-CQDs)
Astilbin
(AST)
for
enhanced
DW
treatment.
The
outer
layer,
enriched
with
Se-CQDs,
rapidly
scavenges
reactive
oxygen
species
(ROS),
effectively
alleviating
stress
at
the
wound
site.
Sequentially,
inner
layer
releases
AST,
exerting
potent
anti-inflammatory
pro-angiogenic
effects.
Preliminary
findings
suggest
these
effects
may
involve
modulation
cytoskeletal
dynamics
peroxisome
function,
contributing
endothelial
cell
migration
angiogenesis.
This
controlled,
sequential
release
MN
establishes
low-oxidative,
microenvironment,
thereby
promoting
angiogenesis
accelerating
repair.
pioneering
integration
AST-loaded
hydrogels
offers
synergistic
strategy,
setting
new
standard
advanced
diabetic
care
substantial
promise.
Язык: Английский
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Microneedle System Coated with Hydrogels Containing Protoporphyrin IX for Potential Application in Pharmaceutical Technology
Methods and Protocols,
Год журнала:
2024,
Номер
7(5), С. 73 - 73
Опубликована: Сен. 13, 2024
The
article
aims
to
outline
the
potential
of
treating
malignant
skin
cancer
with
microneedles
covered
polymer
layers
containing
a
photosensitizer-protoporphyrin
IX
disodium
salt
(PPIX).
usefulness
stereolithography
(SLA),
which
is
form
3D-printing
technology,
for
preparation
microneedle
system
protoporphyrin
was
demonstrated.
SLA
method
allowed
pyramid-shaped
be
printed
that
were
three
different
0.1%
PPIX
hydrogels
based
on
sodium
alginate,
xanthan,
and
poloxamer.
Rheological
tests
microscopic
analysis
performed.
Microneedles
coated
two
poloxamer-based
hydrogel
subjected
release
in
Franz
diffusion
cells.
profile
initially
increased
then
remained
relatively
constant.
amount
substance
released
after
four-hour
test
cells
0.2569
±
0.0683
mg/cm
Язык: Английский