Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157697 - 157697
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(35)
Опубликована: Июнь 27, 2024
Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.
Язык: Английский
Процитировано
49
Advanced Science, Год журнала: 2024, Номер 11(26)
Опубликована: Май 5, 2024
Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune pathway to elicit robust response cancer immunotherapy. Furthermore, doping BG endows system excellent photothermal properties, hence facilitating STING activation reversing immune‐suppressive microenvironment. exhibits favorable angiogenic capacity tissue regenerative potential, promotes cell migration vitro. When combining BG‐Mn anti‐PD‐1 antibody (α‐PD‐1) melanoma, it shows enhanced long‐term memory response. Remarkably, upregulate expression genes related blood vessel formation promote skin regeneration when treating full‐thickness wounds. Overall, Gel serves an effective adjuvant therapy regulate
Язык: Английский
Процитировано
20
Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 1115 - 1129
Опубликована: Ноя. 9, 2024
Язык: Английский
Процитировано
10
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Abstract There is a critical unmet need to improve the treatment of battlefield burns. Rapid and efficient wound protection closure are essential prevent infections, reduce pain, minimize scarring. This study introduces portable, field‐applicable spray system designed instantly apply protective hydrogel coating with therapeutic agents wounds varying sizes shapes for emergency treatments. By mimicking natural silk‐spinning processes, current spray‐on optimized create self‐standing, spider‐web‐like interwoven structure that supports tissue adhesion, cell viability, vascular regeneration. In vivo testing in porcine burn model demonstrates these silk‐based coatings, especially when combined antibiotics, significantly accelerated healing deep partial‐thickness burns compared standard rapid effective performance medical use, offering an advancement functional biomaterials.
Язык: Английский
Процитировано
2
Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216608 - 216608
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
1
Drug Delivery, Год журнала: 2024, Номер 31(1)
Опубликована: Сен. 10, 2024
The unavoidable residual tumor tissue from surgery and the strong aggressiveness of cells pose challenges to postoperative treatment patients, accompanied by in situ recurrence decreased quality life. Therefore, there is an urgent need explore appropriate therapeutic strategies remove after inhibit metastasis surgery. In recent years, with rapid development biomedical materials, study local delivery systems as agents has gradually attracted attention researchers. Injectable situ-forming hydrogel a locally administered agent injected solution that can be loaded various rapidly gels form semi-solid gel at site. This type tightly fills surgical site covers irregular excision surfaces. this paper, we review advances application injectable hydrogels therapy, focusing on matrix materials its different types tumors, well discussing prospects clinical application.
Язык: Английский
Процитировано
5
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101326 - 101326
Опубликована: Ноя. 9, 2024
Ion interference, including intracellular copper (Cu) overload, disrupts cellular homeostasis, triggers mitochondrial dysfunction, and activates cell-specific death channels, highlighting its significant potential in cancer therapy. Nevertheless, the insufficient Cu ions transported by existing ionophores, which are small molecules with short blood half-lives, inevitably hamper effectiveness of cuproptosis. Herein, ESCu@HM nanoreactor, self-assembled from integration H-MnO
Язык: Английский
Процитировано
4
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 18, 2024
Язык: Английский
Процитировано
3
Biomaterials Research, Год журнала: 2025, Номер 29
Опубликована: Янв. 2, 2025
As a complex and dynamically regulated process, wound healing is collaboratively carried out by multiple types of cells. However, the precise mechanisms which these cells contribute to immune regulation are not yet fully understood. Although research on bone regeneration has been quite extensive, application bioactive glass (BG) in skin tissue repair remains still relatively underexplored. The review focuses principles latest progress using BGs for repair, highlighting BGs’ special performance requirements, including biological activity, biocompatibility, biodegradability, antibacterial properties, emphasizing their potential repair. In addition, play substantial role regulating various inflammatory (neutrophils, macrophages, mast cells, etc.) [fibroblasts, vascular endothelial mesenchymal stem (MSCs), etc.] involved healing. also covers recent developments composite materials incorporating BGs, demonstrating ability promote angiogenesis, inhibit biofilms, improve responses chronic wounds. Furthermore, have shown effectiveness promoting epithelial collagen deposition burn wounds as well applications scar management post-tumor resection care. Finally, we summarize our views challenges directions emerging field future.
Язык: Английский
Процитировано
0
Theranostics, Год журнала: 2025, Номер 15(5), С. 1760 - 1786
Опубликована: Янв. 2, 2025
Smart biomaterials with active environmental responsiveness have attracted widespread attention in recent years. Previous studies on bioactive glass (BG) mainly focused the property of bioactivity, while little has been paid to smart response BG. Herein, we propose concept Bioactive Glass Composites (SBGC) which are capable actively responding endogenous disease microenvironment or exogenous physical stimuli, thereby enabling treatment tissue defect sites and ultimately promoting regeneration. In this review, characteristics SBGC different internal external environments described. Subsequently, applications complex repair tumors, infections, diabetes reviewed. By deeply analyzing progress fields, review will point out direction for research next-generation
Язык: Английский
Процитировано
0