Life Sciences, Год журнала: 2024, Номер 358, С. 123199 - 123199
Опубликована: Ноя. 1, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Язык: Английский
Процитировано
134
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Язык: Английский
Процитировано
2
MedComm, Год журнала: 2023, Номер 4(4)
Опубликована: Авг. 1, 2023
Abstract Immune checkpoint inhibitors (ICIs) have shown remarkable success in cancer treatment. However, patients without sufficient antitumor immunity, numerous data indicate that blocking the negative signals elicited by immune checkpoints is ineffective. Drugs stimulate activation‐related pathways are emerging as another route for improving immunotherapy. In addition, development of nanotechnology presents a promising platform tissue and cell type‐specific delivery improved uptake immunomodulatory agents, ultimately leading to enhanced immunotherapy reduced side effects. this review, we summarize discuss latest developments nanoparticles (NPs) immuno‐oncology therapy with focus on lipid‐based NPs (lipid‐NPs), including characteristics advantages various types. Using agonists targeting stimulation interferon genes (STING) transmembrane protein an exemplar, review potential lipid‐NPs augment STING agonist therapy. Furthermore, present recent findings underlying mechanisms how pathway activation fosters immunity regulates tumor microenvironment provide summary distinct preclinical studies clinical trials. Ultimately, conduct critical assessment obstacles future directions utilization enhance
Язык: Английский
Процитировано
32
Deleted Journal, Год журнала: 2024, Номер 6(8)
Опубликована: Июль 29, 2024
Abstract Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory regenerative capabilities. We discuss recent advances in NP-based delivery systems tailored AS treatment highlight MSCs’ roles modulating inflammation promoting vascular repair. Additionally, we examine synergistic effects combining enhanced outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, plaques using MSCs. It also reviews various types metal-based non-metallic utilized therapy. comprehensive overview underscores synergies between cardiovascular disease therapy, emphasizing need further research to fully realize their implications. Graphical
Язык: Английский
Процитировано
13
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Май 16, 2024
Immune checkpoint inhibitors (ICIs) represent a groundbreaking advance in the treatment of malignancies such as melanoma and non-small cell lung cancer, showcasing substantial therapeutic benefits. Nonetheless, efficacy ICIs is limited to small subset patients, primarily benefiting those with “hot” tumors characterized by significant immune infiltration. The challenge converting “cold” tumors, which exhibit minimal activity, into enhance their responsiveness critical complex area current research. Central this endeavor activation cGAS-STING pathway, pivotal nexus between innate adaptive immunity. This pathway’s promotes production type I interferon (IFN) recruitment CD8 + T cells, thereby transforming tumor microenvironment (TME) from “hot”. review comprehensively explores role reconditioning TME, detailing underlying mechanisms immunity highlighting contributions various cells Furthermore, we delve latest clinical research on STING agonists potential combination therapies, targeting pathway. discussion concludes an examination challenges facing advancement promising trials pressing issues within signaling pathway
Язык: Английский
Процитировано
8
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 236 - 250
Опубликована: Янв. 11, 2025
The recent approval of pembrolizumab in recurrent or metastatic cervical cancer warrants further investigations into the usefulness immunotherapies for more durable and less radical interventions. In this study, targeting potential anti-PD-L1-functionalized immunoliposomes was tested a 3D vitro cancer-on-a-chip model. Immunolipsomes were synthesized decorated externally with monovalent anti-PD-L1 Fab' fragments commercially available atezolizumab. Cervical cell lines varying levels PD-L1 expression cultured as spheroids embedded collagen I matrix, treated under flow culture media. Flow cytometry live-cell confocal imaging used to measure interactions uptake untargeted liposomes panel lines. retained specific functionality regardless protein corona formation high serum environments. As such, expressing preferentially internalized environment extracellular matrix present, while low PD-L1-expressing showed no preference either formulation. Importantly, treatments performed monolayer cultures (on plastic) differences between immuno- liposome uptake, including way which endocytosed are trafficked subcellularly. This study demonstrates importance both active passive accumulation strategies achieve nanoparticle targeting. Immunoliposomes remain promising platform development targeted nanotherapies against cancers. However, initial functional tests did not translate directly biological performance should be kept mind future formulations. Furthermore, model developed appeared useful visualizing 3D, live tissue represents cost-effective reproducible studies.
Язык: Английский
Процитировано
1
Next Nanotechnology, Год журнала: 2025, Номер 7, С. 100137 - 100137
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 11, 2025
Background STING is a core signaling hub molecule in the innate immune system, involved various diseases, including infectious autoimmune tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential anti-tumor anti-infective therapies, with agonists emerging as promising approach cancer immunotherapy recent years. This study identifies research trends directions field by collecting analyzing relevant literature. Methods A total of 527 publications regarding 107 about inhibitors were retrieved from WOS Core Collection database. Bibliometric information was extracted CiteSpace VOSviewer software for visualization. Results It shows that on both burgeoning rapidly. The United States China are leading contributors this field. Application primarily focuses immunotherapy, while target inflammation, particularly neuroinflammation acute lung injury. Conclusion Current emphasizes optimizing permeability, efficacy, safety, nanotechnology lipid nanoparticles being prominent delivery techniques. Future expected to focus drug development clinical applications. comprehensive bibliometric analysis provides insights guide further investigation agonist/inhibitor.
Язык: Английский
Процитировано
1
AAPS PharmSciTech, Год журнала: 2025, Номер 26(3)
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Applied Sciences, Год журнала: 2024, Номер 14(19), С. 8948 - 8948
Опубликована: Окт. 4, 2024
Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.
Язык: Английский
Процитировано
8