Xylooligosaccharides from lignocellulosic biomass and their applications as nutraceuticals: a review on their production, purification, and characterization

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 104(13), С. 7765 - 7775

Опубликована: Апрель 16, 2024

Abstract Xylooligosaccharides (XOS) are considered a potent source of prebiotics for humans. The global prebiotic market is expanding in size, was valued at USD 6.05 billion 2021, and expected to grow 14.9% compound annual growth rate between 2022 2030, indicating huge demand. These XOS non‐digestible pentose sugar oligomers comprising mainly xylose. Xylose naturally present the lignocellulosic biomass (LCB), fruits vegetables. Apart from effect, these have been reported reduce blood cholesterol, possess antioxidant effects, increase calcium absorption, colon cancer risk, benefit diabetic patients. primary use feed industry followed by health, medical use, food drinks. LCB contains glucan, xylan lignin. After second‐highest available on globe composed Therefore, fraction has great significance producing food, energy. Glucan exploited commercial production ethanol, xylitol, furfural, hydroxymethyl furfural glucose. As now, limited applications. can be convert XOS. not only helps produce very low price, but also reduction greenhouse gases. Its drinks increasing as it derived abundantly cheaply LCB. article provides review production, purification characterization view their nutraceuticals. © 2024 Authors. Journal Science Food Agriculture published John Wiley & Sons Ltd behalf Society Chemical Industry.

Язык: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Год журнала: 2025, Номер 13(2), С. 241 - 241

Опубликована: Янв. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Язык: Английский

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Role of the microbiome in regulation of the immune system

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Язык: Английский

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Transcriptomics and microbiome insights reveal the protective mechanism of mulberry-derived postbiotics against inflammation in LPS-induced mice

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

Natural food-derived bioactive compounds have garnered increasing attention for their potential to modulate immune responses and promote gut health. In particular, like mulberry-derived postbiotics (MDP) may offer novel therapeutic strategies address inflammation, a key driver of many metabolic disorders. This study examines the protective effects MDP against inflammation in LPS-induced mice, using transcriptomic microbiome analyses explore underlying mechanisms. pretreatment alleviates LPSinduced villous atrophy intestinal barrier damage, promoting recovery morphology. Transcriptomic profiling revealed significant changes gene expression, with 983 upregulated 1220 downregulated genes NC vs LPS comparison, 380 204 LPS+MDP comparison. Enrichment analysis GO KEGG pathways associations transcriptional regulatory activity, NOD-like receptor signaling pathway among differentially expressed genes. Protein-protein interaction identified involved regulation, hub IL6, CXCL10, MYD88 group CD74, CIITA, H2-AB1 MDP-treated group. Microbiome suggested also influence microbiota composition, supporting systemic regulation. These findings highlight MDP's as food additive modulation

Язык: Английский

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Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators

Antibiotics, Год журнала: 2024, Номер 13(8), С. 720 - 720

Опубликована: Авг. 1, 2024

The gut microbiota establishes a mutually beneficial relationship with the host starting from birth, impacting diverse metabolic and immunological processes. Dysbiosis, characterized by an imbalance of microorganisms, is linked to numerous medical conditions, including gastrointestinal disorders, cardiovascular diseases, autoimmune disorders. This promotes proliferation toxin-producing bacteria, disrupts host's equilibrium, initiates inflammation. Genetic factors, dietary choices, drug use can modify microbiota. However, there optimism. Several therapeutic approaches, such as probiotics, prebiotics, synbiotics, postbiotics, microbe-derived products, microbial substrates, aim alter microbiome. review thoroughly explores potential these modulators, analysing recent studies evaluate their efficacy limitations. It underscores promise microbiota-based therapies for treating dysbiosis-related conditions. article aims ensure practitioners feel well-informed up date on most influential methods in this evolving field providing comprehensive current research.

Язык: Английский

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