Inulin Attenuates Blood–Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(36), С. 13325 - 13337
Опубликована: Авг. 29, 2023
Depression
and
vulnerability
to
chronic
stress
are
associated
with
inflammatory
responses
the
loss
of
blood–brain
barrier
(BBB)
integrity.
Dietary
fiber
its
short-chain
fatty
acid
(SCFAs)
metabolites
have
been
reported
affect
neuropsychiatric
disorders.
Here,
a
9-week
treatment
course
inulin
(0.037
g
inulin/kcal)
exhibited
in
unpredictable
mild
(CUMS)
mice
led
antidepressant
anxiolytic
effects,
as
well
improved
neurogenesis
synaptic
plasticity
by
enhancing
CREB/BDNF
signaling.
Importantly,
inhibited
CUMS-induced
decreased
BBB
permeability,
reduced
lipopolysaccharide
(LPS)
brain
penetration,
modulated
TLR4/MyD88/NF-κB
signaling
alleviate
neuroinflammatory
responses.
Furthermore,
protected
gut
integrity
increased
formation
SCFAs.
Enhanced
SCFAs
was
strongly
positively
correlated
behavioral
improvements,
integrity,
We
speculate
that
dietary
may
be
promising
nutritional
intervention
reverse
effects
regulating
protecting
Язык: Английский
The Leap of Inulin Fructans from Food Industry to Medical Application
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(6)
Опубликована: Апрель 17, 2023
Abstract
As
a
dietary
supplement,
the
efficacy
of
prebiotics
has
become
hot
issue
in
recent
years.
Inulin
is
one
internationally
recognized
and
belongs
to
group
non‐digestible
fermentable
carbohydrates.
Currently,
food
industry
increasingly
using
prebiotic
inulin
as
health‐promoting
substrate,
not
just
supplement.
In
addition,
also
shown
great
promise
treatment
various
diseases.
This
article
reviews
application
summarizes
physiological
function
inulin.
Through
review
prospect
research
on
obesity,
diabetes
mental
illness,
it
provides
theoretical
basis
for
joint
development
medical
application.
Язык: Английский
Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism
Phytomedicine,
Год журнала:
2024,
Номер
135, С. 156181 - 156181
Опубликована: Окт. 28, 2024
Язык: Английский
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
Neurochemical Research,
Год журнала:
2023,
Номер
49(2), С. 477 - 491
Опубликована: Ноя. 7, 2023
Язык: Английский
Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone?
Nutritional Neuroscience,
Год журнала:
2024,
Номер
unknown, С. 1 - 24
Опубликована: Июнь 18, 2024
Background:
Chronic
stress
and
chronic
pain
are
closely
linked
by
the
capacity
to
exacerbate
each
other,
sharing
common
roots
in
brain
gut.
The
strict
intersection
between
these
two
neurological
diseases
makes
important
have
a
therapeutic
strategy
aimed
at
preventing
both
maintain
mental
health
patients.
Diet
is
an
modifiable
lifestyle
factor
associated
with
gut-brain
axis
there
growing
interest
its
use
as
adjuvant
main
therapies.
Several
evidence
attest
impact
of
specific
diets
or
nutrients
on
stress-related
disorders
good
degree
certainty.
A
daily
adequate
intake
foods
containing
micronutrients
such
amino
acids,
minerals
vitamins,
well
reduction
consumption
processed
food
products
can
positive
microbiota
gut
health.
Many
endowed
prebiotic,
anti-inflammatory,
immunomodulatory
neuroprotective
potential
which
make
them
useful
tools
helping
management
Dietary
regimes,
intermittent
fasting
caloric
restriction,
promising,
although
further
studies
needed
optimize
protocols
according
patient's
medical
history,
age
sex.
Moreover,
supporting
diet
possible
attenuate
comorbidities
obesity,
gastrointestinal
dysfunction
mood
disorders,
thus
reducing
healthcare
costs
related
pain.
Язык: Английский
Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 8, 2024
Abstract
Background
Increasing
evidence
has
demonstrated
that
an
imbalance
in
the
microbiota-gut-brain
axis
exerts
essential
effect
on
pathophysiology
of
depressive
and
anxiety
disorders.
Our
previous
research
revealed
timing
inulin
administration
altered
its
influence
CUMS-induced
depression;
however,
it
is
still
unclear
if
gut-brain
primarily
responsible
for
these
effects.
Results
Serum
metabolomics
analysis
showed
treatment
can
alleviate
inflammatory
response
CUMS-treated
mice
amino
acid
metabolic
pathways
were
crucial
anxiolytic
antidepressant
The
time
seemed
to
modify
effects
inulin,
intervention
evening
was
more
pronounced
improving
metabolism
inhibiting
than
morning
treatment.
In
addition,
significantly
reduced
serum
glucose
insulin
levels.
main
differential
metabolites,
including
fenofibric
acid,
4’-Hydroxyfenoprofen
glucuronide
5-(4-Hydroxybenzyl)thiazolidine-2,4-dione
may
play
important
roles
ability
inulin.
Fecal
microbiota
transplantation
confirmed
alleviated
anxiety-
depression-like
behaviors
via
axis.
Conclusions
results
suggest
effective
alleviating
metabolism.
This
study
provides
a
new
potential
link
between
chrono-nutrition,
which
indicates
appropriate
better
effect.
Язык: Английский
Prebiotic Inulin Alleviates Anxiety and Depression-Like Behavior in Alcohol Withdrawal Mice by Modulating the Gut Microbiota and 5-Ht Metabolism
Опубликована: Янв. 1, 2024
Язык: Английский
Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
288, С. 138698 - 138698
Опубликована: Дек. 11, 2024
Язык: Английский
Nöropeptid W, kronik stresli sıçanlarda bilişsel bozukluğu ve kaygı benzeri davranışları hafifletir
Acta Medica Nicomedia,
Год журнала:
2023,
Номер
6(3), С. 334 - 339
Опубликована: Окт. 21, 2023
Objective:
NPW
plays
a
regulatory
role
in
the
neuroendocrine
response
to
stress
and
activation
of
HPA
axis.
The
current
study
aimed
investigate
effects
peripherally
administered
on
cognitive
functions
anxiety-like
behavior
rats
under
chronic
conditions.
Methods:
Wistar
albino
(250-290
gr)
male
were
randomly
divided
as
control,
group,
exposed
NPW-treated
(0.1
µg/kg,
subcutaneously)
group.
Chronic
was
induced
by
exposing
animals
water
avoidance
(WAS)
for
1
h/day
ten
consecutive
days.
At
end
experimental
procedure,
an
object
recognition
test
used
evaluate
functions,
hole-board
assess
anxiety
levels.
After
experiments,
blood
samples
collected
measure
corticosterone
levels.
Results:
WAS
significant
increases
level
when
compared
with
control
(p
Язык: Английский