Nöropeptid W, kronik stresli sıçanlarda bilişsel bozukluğu ve kaygı benzeri davranışları hafifletir DOI Creative Commons
Sevil Arabacı Tamer, Emine KARAHAN

Acta Medica Nicomedia, Journal Year: 2023, Volume and Issue: 6(3), P. 334 - 339

Published: Oct. 21, 2023

Objective: NPW plays a regulatory role in the neuroendocrine response to stress and activation of HPA axis. The current study aimed investigate effects peripherally administered on cognitive functions anxiety-like behavior rats under chronic conditions. Methods: Wistar albino (250-290 gr) male were randomly divided as control, group, exposed NPW-treated (0.1 µg/kg, subcutaneously) group. Chronic was induced by exposing animals water avoidance (WAS) for 1 h/day ten consecutive days. At end experimental procedure, an object recognition test used evaluate functions, hole-board assess anxiety levels. After experiments, blood samples collected measure corticosterone levels. Results: WAS significant increases level when compared with control (p

Language: Английский

Inulin Attenuates Blood–Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress DOI
Lei Wang, Zhuo Wang,

Yongli Lan

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(36), P. 13325 - 13337

Published: Aug. 29, 2023

Depression and vulnerability to chronic stress are associated with inflammatory responses the loss of blood–brain barrier (BBB) integrity. Dietary fiber its short-chain fatty acid (SCFAs) metabolites have been reported affect neuropsychiatric disorders. Here, a 9-week treatment course inulin (0.037 g inulin/kcal) exhibited in unpredictable mild (CUMS) mice led antidepressant anxiolytic effects, as well improved neurogenesis synaptic plasticity by enhancing CREB/BDNF signaling. Importantly, inhibited CUMS-induced decreased BBB permeability, reduced lipopolysaccharide (LPS) brain penetration, modulated TLR4/MyD88/NF-κB signaling alleviate neuroinflammatory responses. Furthermore, protected gut integrity increased formation SCFAs. Enhanced SCFAs was strongly positively correlated behavioral improvements, integrity, We speculate that dietary may be promising nutritional intervention reverse effects regulating protecting

Language: Английский

Citations

17
The Leap of Inulin Fructans from Food Industry to Medical Application DOI
Xuemei Zhou,

Shixu Wang,

Chongchong Xu

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(6)

Published: April 17, 2023

Abstract As a dietary supplement, the efficacy of prebiotics has become hot issue in recent years. Inulin is one internationally recognized and belongs to group non‐digestible fermentable carbohydrates. Currently, food industry increasingly using prebiotic inulin as health‐promoting substrate, not just supplement. In addition, also shown great promise treatment various diseases. This article reviews application summarizes physiological function inulin. Through review prospect research on obesity, diabetes mental illness, it provides theoretical basis for joint development medical application.

Language: Английский

Citations

12
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes DOI

Susu Lin,

Ziwei Chen,

Zhaoruncheng Wu

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(2), P. 477 - 491

Published: Nov. 7, 2023

Language: Английский

Citations

7
Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism DOI
Kuan Li, Wei Wei, Chongchong Xu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156181 - 156181

Published: Oct. 28, 2024

Language: Английский

Citations

2
Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone? DOI
Alessia Costa, Elena Lucarini

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: June 18, 2024

Background: Chronic stress and chronic pain are closely linked by the capacity to exacerbate each other, sharing common roots in brain gut. The strict intersection between these two neurological diseases makes important have a therapeutic strategy aimed at preventing both maintain mental health patients. Diet is an modifiable lifestyle factor associated with gut-brain axis there growing interest its use as adjuvant main therapies. Several evidence attest impact of specific diets or nutrients on stress-related disorders good degree certainty. A daily adequate intake foods containing micronutrients such amino acids, minerals vitamins, well reduction consumption processed food products can positive microbiota gut health. Many endowed prebiotic, anti-inflammatory, immunomodulatory neuroprotective potential which make them useful tools helping management Dietary regimes, intermittent fasting caloric restriction, promising, although further studies needed optimize protocols according patient's medical history, age sex. Moreover, supporting diet possible attenuate comorbidities obesity, gastrointestinal dysfunction mood disorders, thus reducing healthcare costs related pain.

Language: Английский

Citations

1
Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism DOI Creative Commons
Ping Chen,

Fanyang Chen,

Tao Hou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Abstract Background Increasing evidence has demonstrated that an imbalance in the microbiota-gut-brain axis exerts essential effect on pathophysiology of depressive and anxiety disorders. Our previous research revealed timing inulin administration altered its influence CUMS-induced depression; however, it is still unclear if gut-brain primarily responsible for these effects. Results Serum metabolomics analysis showed treatment can alleviate inflammatory response CUMS-treated mice amino acid metabolic pathways were crucial anxiolytic antidepressant The time seemed to modify effects inulin, intervention evening was more pronounced improving metabolism inhibiting than morning treatment. In addition, significantly reduced serum glucose insulin levels. main differential metabolites, including fenofibric acid, 4’-Hydroxyfenoprofen glucuronide 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione may play important roles ability inulin. Fecal microbiota transplantation confirmed alleviated anxiety- depression-like behaviors via axis. Conclusions results suggest effective alleviating metabolism. This study provides a new potential link between chrono-nutrition, which indicates appropriate better effect.

Language: Английский

Citations

0
Prebiotic Inulin Alleviates Anxiety and Depression-Like Behavior in Alcohol Withdrawal Mice by Modulating the Gut Microbiota and 5-Ht Metabolism DOI
Kuan Li, Wei Wei, Chongchong Xu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis DOI
Ping Chen,

Fanyang Chen,

Tao Hou

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138698 - 138698

Published: Dec. 11, 2024

Language: Английский

Citations

0
Nöropeptid W, kronik stresli sıçanlarda bilişsel bozukluğu ve kaygı benzeri davranışları hafifletir DOI Creative Commons
Sevil Arabacı Tamer, Emine KARAHAN

Acta Medica Nicomedia, Journal Year: 2023, Volume and Issue: 6(3), P. 334 - 339

Published: Oct. 21, 2023

Objective: NPW plays a regulatory role in the neuroendocrine response to stress and activation of HPA axis. The current study aimed investigate effects peripherally administered on cognitive functions anxiety-like behavior rats under chronic conditions. Methods: Wistar albino (250-290 gr) male were randomly divided as control, group, exposed NPW-treated (0.1 µg/kg, subcutaneously) group. Chronic was induced by exposing animals water avoidance (WAS) for 1 h/day ten consecutive days. At end experimental procedure, an object recognition test used evaluate functions, hole-board assess anxiety levels. After experiments, blood samples collected measure corticosterone levels. Results: WAS significant increases level when compared with control (p

Language: Английский

Citations

0