Evaluation of an augmented reality navigational guidance platform for percutaneous procedures in a cadaver model

Journal of Medical Imaging, Год журнала: 2024, Номер 11(06)

Опубликована: Фев. 15, 2024

PurposeThe objective of this study is to review the accuracy an augmented reality navigational guidance system designed facilitate improved visualization, guidance, and during percutaneous needle-based procedures including biopsies ablations.ApproachUsing HoloLens 2, registers projects 3D CT-based models segmented anatomy along with live ultrasound, fused electromagnetically tracked instruments ultrasound probes needles, giving operator comprehensive stereoscopic visualization for intraoperative planning navigation procedures.Tracked needles were guided targets implanted in a cadaveric model using system. Image fusion registration error, multimodality error measured as post-registration distance between corresponding point CT coordinate systems, target Euclidean needle tip after placement, targeting metrics. A t-distribution was used statistical analysis.ResultsThree operators performed 36 total passes, 18 measure image on four targets. The average depth each pass 8.4 cm from skin center. Mean IFRE 4.4 mm (H0: μ=5 mm, P<0.05). TRE 2.3 P<0.00001).ConclusionsThe demonstrated high AR percutaneous, procedures. This suggests ability clinical performance such ablations biopsies.

Язык: Английский

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Clinical application status and prospect of the combined anti-tumor strategy of ablation and immunotherapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Сен. 5, 2022

Image-guided tumor ablation eliminates cells by physical or chemical stimulation, which shows less invasive and more precise in local treatment. Tumor provides a treatment option for medically inoperable patients. Currently, clinical techniques are widely used practice, including cryoablation, radiofrequency (RFA), microwave (MWA). Previous studies indicated that activated immune responses besides killing directly, such as short-term anti-tumor response, immunosuppression reduction, specific non-specific enhancement, the reduction disappearance of distant foci. However, transiently induced response. The combination immunotherapy is expected to achieve better therapeutic results application. In this paper, we provided summary principle, application status, effects technologies Moreover, discussed different with proposed possible solutions challenges encountered combined therapy. It hoped provide new idea reference combinate immunotherapy.

Язык: Английский

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Percutaneous microwave ablation for lung tumors: a retrospective case-control study of conventional CT and C-arm CT guidance

Quantitative Imaging in Medicine and Surgery, Год журнала: 2023, Номер 13(9), С. 5737 - 5747

Опубликована: Авг. 29, 2023

Although conventional computed tomography (cCT) is the mainstream guidance equipment for lung microwave ablation (MWA), C-arm CT can provide 3-dimensional (3D) CT-like images reconstructed from 2-dimensional (2D) digital subtraction angiography (DSA) information within 8 seconds, highlighting its utility as a new tool. This retrospective case-control study was performed to evaluate clinical performance of percutaneous MWA tumors using cCT and guidance.From April 2015 2020, 101 consecutive patients with solitary who underwent at our single center (Zhengzhou, China) were divided into 2 groups: group (n=56), unarmed puncture, (n=45), iGuide navigation-assisted puncture. The primary endpoints technical success, efficacy, puncture scoring (PS), complete (CA) rate. secondary complications, median progression-free survival (mPFS), overall (mOS).The success rates 100% in both group. efficacies 93.3% 91.1% group, respectively, no statistical difference (P=0.67). PS (2.9 vs. 2.5, P=0.02), total procedure time (TPT; 39.3 50.0 min, P<0.001), (PT; 12.6 15.7 P=0.001), irradiation effective dose (ED; 15.2 20.9 mSV, P<0.001) showed significances between those (AT; 9.1 9.6 P=0.36), CA rate (93.3% 92.9%, P=0.93), local tumor progression (LTP) (11.1% 8.9%, P=0.98), mPFS (9.5 10.1 months, P=0.52), mOS (37.9 38.8 P=0.67) statistically significant groups.C-arm feasible MWA, which increase decrease TPT.

Язык: Английский

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Transbronchial Tumor Ablation

Current Pulmonology Reports, Год журнала: 2024, Номер 13(1), С. 103 - 115

Опубликована: Янв. 10, 2024

Язык: Английский

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Recent research advances on simulation modeling of temperature distribution in microwave ablation of lung tumors

Computer Assisted Surgery, Год журнала: 2023, Номер 28(1)

Опубликована: Апрель 5, 2023

Lung tumor is the first malignant with highest mortality, but only no more than one-third of patients can be treated by surgical resection. Microwave ablation (MWA) has become a new adjuvant therapeutic mean for lung tumors because its low trauma, short treatment time, large volume and wide application range. However, parameters MWA, such as input power still depend on doctors’ experience, which leads to ineffectiveness MWA. Therefore, accurate modeling temperature distribution MWA significant technical problem solved. Recent research was devoted personalized characterization parameters, finite element analysis in effect evaluation. In this paper, review recently obtained results data will presented discussed.

Язык: Английский

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Transmission Coefficient-Based Monitoring of Microwave Ablation: Development and Experimental Evaluation in Ex Vivo Tissue

IEEE Transactions on Biomedical Engineering, Год журнала: 2023, Номер 71(4), С. 1269 - 1280

Опубликована: Ноя. 9, 2023

Objectives: To assess the feasibility of monitoring transient evolution thermal ablation zones with a microwave transmission coefficient-based technique. xmlns:xlink="http://www.w3.org/1999/xlink">Methods: Microwave was performed in ex vivo bovine liver two 2.45 GHz directional antennas. A custom apparatus developed to enable periodic switching between "heating mode" when power from generator coupled antennas, and "monitoring mode", antennas were network analyzer for broadband coefficient ( ${\mathbf{s}}_{21}$ ) measurements. Experiments applied powers ranging 30–50 W per antenna 53–1219 s. Transient spectra over course ablations analyzed determine predicting extent compared against ground truth assessment images sectioned tissue. linear regression-based mapping datasets derived predict extent. xmlns:xlink="http://www.w3.org/1999/xlink">Results: Normalized average initially rapidly decreased then increased before asymptotically approaching steady state, transition time 53 s (45 W) 109 (30 W). Analysis zone indicated complete 230–350 The relative prediction error data range 1.6%–2.3% truth. xmlns:xlink="http://www.w3.org/1999/xlink">Conclusion: We have demonstrated using measurements xmlns:xlink="http://www.w3.org/1999/xlink">Significance: presented technique has potential contribute towards addressing clinical need method zones.

Язык: Английский

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Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors

International Journal of Hyperthermia, Год журнала: 2022, Номер 39(1), С. 1264 - 1275

Опубликована: Сен. 22, 2022

Purpose To assess the feasibility of delivering microwave ablation for targeted treatment aldosterone producing adenomas using image-based computational models.Methods We curated an anonymized dataset diagnostic 11C-metomidate PET/CT images 14 patients with (APA). A semi-automated approach was developed to segment APA, adrenal gland, and adjacent organs within 2 cm APA boundary. The segmented volumes were used implement patient-specific 3D electromagnetic-bioheat transfer models a 2.45 GHz directional applicator. Ablation profiles quantitatively assessed based on extent target encompassed by ablative thermal dose, while limiting damage normal tissue sensitive critical structures.Results Across patients, tumor ranged between 393 mm3 2,395 mm3. On average, 70% received dose 240CEM43, non-target structures, thermally sparing 83.5–96.4% gland. Average duration 293 s (range: 60–600 s). Simulations indicated coverage limited when axis applicator not well aligned major APA.Conclusions Image-based demonstrate potential targets surrounding structures.

Язык: Английский

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Guidelines for power and time variables for microwave ablation in porcine lung in vitro

Journal of Cancer Research and Therapeutics, Год журнала: 2024, Номер 20(4), С. 1150 - 1156

Опубликована: Авг. 1, 2024

Determination of the appropriate ablative parameters is key to success and safety microwave ablation (MWA) lung tumors. The purpose this study was provide guidelines recommendations for optimal time power tumor MWA.

Язык: Английский

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Histology-validated electromagnetic characterization of ex-vivo ovine lung tissue for microwave-based medical applications

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 11, 2024

Abstract Microwave thermal ablation is an established therapeutic technique for treating malignant tissue in various organs. Its success greatly depends on the knowledge of dielectric properties targeted and how they change during treatment. Innovation lung navigation has recently increased clinical interest transbronchial microwave treatment cancer. However, not largely characterized, thus its investigation prior post key. In this work, ex-vivo ovine parenchyma untreated ablated at 2.45 GHz were recorded 0.5–8 frequency range. The measured fitted to 2-pole Cole–Cole relaxation model obtained parameters compared. Based observed changes parameters, physical post-ablation discussed validated through histology analysis. Additionally, investigate link achieved results with rate heating, another two sets samples, originating from both porcine tissues, heated a oven different times powers. Dielectric same It was found that experiences behavior according heating rates: increase while decrease low rates heating. hypothesized, by histology, ablation, although losing water, air cavities deform, lowering content increasing resulting properties.

Язык: Английский

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Assessment of thermochromic phantoms for characterizing microwave ablation devices

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 25, 2024

Background and Purpose: Thermochromic gel phantoms provide a controlled medium for visual assessment of thermal ablation device performance. However, there are limited studies reporting on the comparative profiles assessed in thermochromic against those ex vivo tissue. The objective this study was to compare microwave zones tissue mimicking phantom bovine liver, report measurements temperature dependent dielectric properties phantom. Methods: polyacrylamide were fabricated following previously reported protocol. Phantom samples heated temperatures range 20-90 degC temperature-controlled water bath, colorimetric analysis images taken after heating used develop calibration between color changes which heated. Using custom, 2.45 GHz water-cooled antenna, ablations performed fresh liver using 65 W applied 5 min or 10 (n = 3 each power/time combination). Broadband (500 MHz-6 GHz) temperature-dependent measured over 22-100 degC. Results: Colorimetric showed that sharp change commences at 57 Short long axes zone (as by isotherm) W, aligned with extents observed liver. setting, average 23.7% smaller short axis 7.4 % than Measurements relative permittivity, conductivity, volumetric heat capacity largely followed similar trends published values Conclusion: controlled, reproducible devices energy delivery settings, though size shapes may not accurately represent sizes under conditions.

Язык: Английский

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