Design and Rationale of Prolonged Nightly Fasting for Multiple Myeloma Prevention (PROFAST): Protocol for a Randomized Controlled Pilot Trial (Preprint) DOI Creative Commons
David Jungpa Lee,

Elizabeth O’Donnell,

Noopur Raje

и другие.

Опубликована: Июль 31, 2023

BACKGROUND Obesity is an established, modifiable risk factor of multiple myeloma (MM); yet, no lifestyle interventions are routinely recommended for patients with overweight or obesity MM precursor conditions. Prolonged nightly fasting a simple, practical dietary regimen supported by research, suggesting that the synchronization feeding-fasting timing sleep-wake cycles favorably affects metabolic pathways implicated in MM. We describe design and rationale randomized controlled pilot trial evaluating efficacy regular, prolonged nighttime schedule among individuals at high developing related lymphoid malignancy. OBJECTIVE aim to investigate effects 4-month on body composition tumor biomarkers monoclonal gammopathy undetermined significance (MGUS), smoldering (SMM), Waldenström macroglobulinemia (SWM). METHODS Individuals MGUS, SMM, SWM aged ≥18 years BMI ≥25 kg/m<sup>2</sup> either 14-hour intervention healthy education control group. Participants’ baseline diet patterns characterized through two 24-hour recalls: questionnaires querying demographic, comorbidity, lifestyle, quality-of-life information; wrist actigraphy measurements 7 days. Fasting participants one-on-one telephone counseling health coach automated SMS text messaging support goals. Primary end points composition, including visceral subcutaneous fat (by dual-energy x-ray absorptiometry); bone marrow adiposity histology); biomarkers, specifically M-proteins serum free light-chain concentrations gel-based assays), assessed after study period; changes therein from evaluated using repeated measures mixed-effects model accounts correlation between follow-up generally robust missing data. Feasibility as participant retention (percent dropout each arm) percentage days achieved ≥14-hour fast. RESULTS The PROlonged FASTing (PROFAST) was funded June 2022. Participant recruitment commenced April 2023. As July 2023, six consented study. expected be completed 2024, data analysis results published first quarter 2025. CONCLUSIONS PROFAST serves important step exploring premise strategy obesity-related mechanisms myelomagenesis. In feasibility impact adipose tissue, burden, this may generate hypotheses regarding underlying development ultimately inform clinical public strategies prevention. CLINICALTRIAL ClinicalTrials.gov NCT05565638; http://clinicaltrials.gov/ct2/show/NCT05565638 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/51368

Язык: Английский

Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial DOI Creative Commons
Jonas Salling Quist, Hanne Pedersen, Marie M. Jensen

и другие.

The Lancet Healthy Longevity, Год журнала: 2024, Номер 5(5), С. e314 - e325

Опубликована: Апрель 5, 2024

Time-restricted eating (TRE) has been suggested to be a simple, feasible, and effective dietary strategy for individuals with overweight or obesity. We aimed investigate the effects of 3 months 10-h per-day TRE follow-up on bodyweight cardiometabolic risk factors in at high type 2 diabetes.

Язык: Английский

Процитировано

12
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity? DOI Creative Commons

Maria Eugenia Parrotta,

Luca Colangeli,

Valeria SCIPIONE

и другие.

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

1
Navigating challenges and adherence in time‐restricted eating: A qualitative study DOI Creative Commons
Hilmi Sulaiman Rathomi, Nahal Mavaddat, Judith Katzenellenbogen

и другие.

Nutrition & Dietetics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Abstract Aims Adherence to any dietary approach is crucial for achieving long‐term benefits. This qualitative study aims explore the facilitators and barriers adherence, how individuals in community settings navigate time‐restricted eating their daily lives. Methods Semi‐structured, in‐depth interviews were conducted with 21 participants who had practised (confining window <10h a day; excluding periodic fasting methods like 5:2 or alternate day fasting) periods ranging from 3 months more than 5 years. A content analysis, underpinned by Capability‐Opportunity‐Motivation‐Behaviour Model, identified multiple facilitators, barriers, strategies that evolved over practice. Results Key included simplicity versatility of eating, maintaining non‐obsessive non‐dieting mindset, having supportive environment. Barriers hunger food cravings, an obsessive mindset during initial stages, conflicting schedules social occasions, including holidays. Participants employed several coping successfully adherence reported confidence as lifestyle contributes better health weight management. Conclusion Our findings suggest successful implementation requires flexibility viewing it short‐term loss tool. Guidelines are needed help practitioners implement practices promote healthier behaviours.

Язык: Английский

Процитировано

1
Multigenerational diabetes mellitus DOI Creative Commons

Jennifer M. Thornton,

Nishel M. Shah, Karen A. Lillycrop

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 15, 2024

Gestational diabetes (GDM) changes the maternal metabolic and uterine environment, thus increasing risk of short- long-term adverse outcomes for both mother child. Children mothers who have GDM during their pregnancy are more likely to develop Type 2 Diabetes (T2D), early-onset cardiovascular disease when they themselves become pregnant, perpetuating a multigenerational increased disease. The negative effect is exacerbated by obesity, which induces greater derangement fetal adipogenesis growth. Multiple factors, including genetic, epigenetic metabolic, interact with lifestyle factors contribute development GDM. Genetic particularly important, 30% women having at least one parent T2D. Fetal modifications occur in response GDM, may mediate multi- transgenerational risk. Changes metabolome primarily related fatty acid oxidation, inflammation insulin resistance. These might be effective early biomarkers allowing identification prior hyperglycaemia. impact intra-uterine environment on developing fetus, “developmental programming”, has multisystem effect, but its influence important as it will determine baseline sensitivity, future challenges. Identifying critical window interventions key our ability improve population health.

Язык: Английский

Процитировано

6
Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis DOI Creative Commons
Yu-En Chen, Han‐Mou Tsai, Yu‐Kang Tu

и другие.

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 12, 2024

Intermittent fasting (IF) holds promise for enhancing metabolic health. However, the optimum IF forms and their superiority over continuous energy restriction (CER) remain unclear due to disconnected findings.

Язык: Английский

Процитировано

4
Protocol for a 1‐year randomised, controlled, parallel group, open‐label trial on the effects and feasibility of time‐restricted eating in individuals with type 2 diabetes‐ The Restricted Eating Time in the Treatment of Type 2 Diabetes (RESET2) trial DOI Creative Commons
Anne‐Ditte Termannsen, Annemarie Varming, Natasja Bjerre

и другие.

Diabetic Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Abstract Aim Time‐restricted eating (TRE) limits the time for food intake to typically 6–10 h/day without other dietary restrictions. The aim of RESET2 (the REStricted Eating Time in treatment type 2 diabetes) trial is investigate effects on glycaemic control (HbA 1c ) and feasibility a 1‐year TRE intervention individuals with overweight/obesity diabetes. present paper describe protocol trial. Methods randomised, controlled, parallel‐group, open‐label One hundred sixty diabetes >53 mmol/mol (>7.0%)), Body Mass Index ≥25 kg/m will be randomised standard care plus TRE, or habitual living. Both group follow including regular clinical visits 3–4 times/year. divided into two periods: (1) 3‐month period fixed window self‐selected timing obtain data from participants' experiences (2) 9‐month individually adjusted period. Participants instructed reduce their by minimum 3 compared an 8–10 h/day. Test days scheduled at baseline, after months 1 year. primary outcome HbA (evaluated year randomisation) secondary outcomes are body weight, fat mass, continuous glucose monitoring derived time‐in‐range use antidiabetic medicine randomisation). Additionally, we conduct process evaluation assess whether functioned as hypothesised.

Язык: Английский

Процитировано

0
Comparing the effectiveness of calorie restriction with and without time-restricted eating on the circadian regulation of metabolism – rationale and protocol of a three-arm randomised controlled trial in adults at risk of type 2 diabetes DOI Creative Commons

You Jin Chang,

Laurent Turner, Xiao Tong Teong

и другие.

Nutrition Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Effect of Time-Restricted Eating on Sleep Quality and Body Composition: A Systematic Review DOI
Bianca Aparecida de Sousa, Amanda C. Silva, Maria Luísa A Ferreira

и другие.

Nutrition Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Context Time-restricted eating (TRE) is a dietary approach that consolidates energy intake in restricted period during the day. It an alternative to weight loss and might be important sleep quality. Objective To review current literature related effects of TRE on quality body composition adults. Data Sources A search PubMed, Scopus, Web Science (Clarivate), Biblioteca Virtual em Saúde/Bireme databases was carried out until May 2024. extraction Reviewed articles included clinical, interventional (controlled or uncontrolled) studies including individuals older than 18 years, with no gender restriction. The interventions had control feeding time, could assessed by any validated method, polysomnography, actigraphy, assessment questionnaires. analysis Eleven were this systematic review. Study samples varied between 19 137 participants, predominance female participants 10 studies. Seven (58.3%) tested intervention 8 hours TRE, range 4 weeks 12 months. All observed loss. Nine showed reductions fat mass, 2 visceral mass. No studies, independently changes, objectively changes duration after interventions. However, subjective evaluation, 1 study found reduction 30 ± 13 minutes, increase latency 7 3 efficiency 2% 1% group treated compared group. Conclusion seems effective mass reduction, but most effect parameters. There lack standardized methods for measurements reviewed these results provide valuable data design formulation new well-founded assessing using objective different Systematic Review Registration PROSPERO registration No. CRD42024524598.

Язык: Английский

Процитировано

0
Randomised controlled trial of preconception lifestyle intervention on maternal and offspring health in people with increased risk of gestational diabetes: study protocol for the BEFORE THE BEGINNING trial DOI Creative Commons
Md Abu Jafar Sujan, HS Skarstad,

G Rosvold

и другие.

BMJ Open, Год журнала: 2023, Номер 13(10), С. e073572 - e073572

Опубликована: Окт. 1, 2023

Introduction Gestational diabetes mellitus (GDM) is associated with increased risk for type 2 in the mother and cardiometabolic diseases child. The preconception period an optimal window to adapt lifestyle improved outcomes both Our aim determine effect of a intervention, initiated before continued throughout pregnancy, on maternal glucose tolerance other infant outcomes. Methods analysis This ongoing randomised controlled trial has included 167 females aged 18–39 years old at GDM who are contemplating pregnancy. participants were randomly allocated 1:1 intervention or control group. consists exercise (volume set by heart rate-based app corresponds ≥ 1 hour weekly 80% individual rate maximum), time-restricted eating (≤ 10 hours/day energy intake). primary outcome measure gestational week 28. Maternal offspring measured during delivery, 6–8 weeks post partum. Primary secondary continuous measures will be compared between groups based ‘intention treat’ principle using linear mixed models. Ethics dissemination Regional Committees Medical Health Research Norway approved study (REK 143756). anonymised results submitted publication posted publicly accessible database clinical results. Trial registration number Clinical gov NCT04585581 .

Язык: Английский

Процитировано

9
"It just made sense to me!” A Qualitative Exploration of Individual Motivation for Time-Restricted Eating DOI Creative Commons
Hilmi Sulaiman Rathomi, Nahal Mavaddat, Judith Katzenellenbogen

и другие.

Appetite, Год журнала: 2024, Номер 204, С. 107751 - 107751

Опубликована: Ноя. 1, 2024

Time-Restricted Eating (TRE), a form of intermittent fasting, has gained popularity for weight control and metabolic health. It is not incorporated into dietary clinical guidelines, hence generally being recommended to the public. This qualitative study explores how individuals have discovered TRE as practice their motivations practising it. Using purposive snowball sampling, we recruited 21 participants who had engaged in at least 3 months (range over 5 years). In-depth interviews were conducted with an interview guide developed based on Health Belief Model. We utilised inductive coding process thematic analysis identify factors motivating adoption. Seven main themes emerged: (1) dissatisfaction resistance prior or traditional approaches, (2) perceived broader health benefits, (3) principles deemed logical, (4) low no cost adoption, (5) manageable psychosocial barriers, (6) non-restrictive easy use, (7) compatibility personal lifestyle. provided insights early phase adoption among real world settings. Future research should explore practitioners' perspectives better understand acceptability potential use management approach.

Язык: Английский

Процитировано

3