Pyrazole derivatives: Recent advances in discovery and development of pesticides
Chinese Chemical Letters,
Год журнала:
2025,
Номер
unknown, С. 110912 - 110912
Опубликована: Фев. 1, 2025
Язык: Английский
Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm Spodoptera litura: design, characterization, in vivo bio-evaluation, toxicological effectiveness, and study their mode of action
RSC Advances,
Год журнала:
2025,
Номер
15(2), С. 1391 - 1406
Опубликована: Янв. 1, 2025
New
insecticidal
agents
based
on
quinoxaline
derivatives
targeting
the
cotton
leafworm,
Spodoptera
litura
.
Язык: Английский
Discovery of Novel Isoxazoline Derivatives Containing Pyrazolamide Fragment as Insecticidal Candidates
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Lepidopteran
species
cause
significant
harm
to
agricultural
yields
and
food
quality.
In
this
study,
a
series
of
innovative
isoxazoline
derivatives
incorporating
pyrazolamide
moieties
were
carefully
designed
synthesized
as
potential
insecticidal
agents.
Among
these,
compound
F16
demonstrated
an
LC50
value
0.01
mg/L
against
Plutella
xylostella,
surpassing
that
the
lead
fluxametamide
(LC50
=
0.15
mg/L).
Furthermore,
exhibited
broad-spectrum
activity
Pyrausta
nubilalis,
Spodoptera
frugiperda,
Chilo
suppressalis,
Aphis
craccivora,
Sogatella
furcifera.
Notably,
possessed
low
toxicity
Danio
rerio,
whereas
displayed
moderate
toxicity.
molecular
docking
analysis
potent
is
likely
mediated
by
its
specific
interactions
with
γ-GABA
receptors
primarily
through
formation
hydrogen
bonds
key
residues.
Density
functional
theory
calculations
electrostatic
potentials
also
performed
gain
insights
into
behavior
F16.
These
findings
suggest
promising
candidate
for
further
investigation
novel
pesticide.
Язык: Английский
Design, Synthesis, and Herbicidal Activities of N-(5-(3,5-Methoxyphenyl)-(thiazole-2-yl))phenoxyacetamide Derivatives
Na Liu,
Yuanhui Wan,
Zhendong Bai
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(42), С. 23097 - 23107
Опубликована: Авг. 13, 2024
Thiazole
and
phenoxyacetic
acid
are
key
moieties
in
many
natural
synthetic
biologically
active
agents.
A
series
of
Язык: Английский
Thiazole and Isothiazole Chemistry in Crop Protection
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
73(1), С. 30 - 46
Опубликована: Дек. 27, 2024
Thiazole
and
isothiazole
are
types
of
five-membered
heterocycles
that
contain
both
sulfur
nitrogen
atoms.
They
have
gained
attention
in
the
field
green
pesticide
research
due
to
their
low
toxicity,
strong
biological
activity,
ability
undergo
diverse
structural
modifications.
By
incorporating
thiazole
groups
into
various
compounds,
researchers
been
able
create
a
wide
range
pesticides
with
broad-spectrum
effectiveness.
Understanding
relationship
between
structure
these
compounds
activities
is
crucial
for
development
new
highly
potent
pesticides.
This
review
highlights
derivatives
aims
inspire
innovative
based
on
structures.
Язык: Английский