Flavonoids as Anticancer Agents

Nutrients, Год журнала: 2020, Номер 12(2), С. 457 - 457

Опубликована: Фев. 12, 2020

Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine cocoa-based products the main dietary sources flavonoids. have been shown to possess wide anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate arresting cell cycle, induce apoptosis, autophagy, suppress cancer proliferation invasiveness. dual action regarding ROS homeostasis—they act antioxidants under normal conditions potent pro-oxidants cells triggering apoptotic pathways downregulating pro-inflammatory signaling pathways. This article reviews biochemical properties bioavailability flavonoids, their activity its mechanisms action.

Язык: Английский

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Concept, mechanism, and applications of phenolic antioxidants in foods

Journal of Food Biochemistry, Год журнала: 2020, Номер 44(9)

Опубликована: Июль 20, 2020

In this review, the concept of phenolic antioxidants, mechanisms action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety free radicals. The mechanism actions involved either hydrogen atom transfer, transfer single electron, sequential proton loss electron chelation transition metals. foods, PCs act antioxidants which are measured several in vitro spectroscopic methods. found milk wide range dairy products sole purposes color, taste, storage stability, quality enhancement. role three types food additives, that is, antimicrobial, antioxidant, flavoring agents critically literature revealed present foods possess health benefits such antibacterial, antihyperlipidemic, anticancer, cardioprotective, neuroprotective, antidiabetic properties. Practical strong safer than synthetic antioxidants. occurrence plant warranted continuous review applications. This therefore, presented updated comprehensive overview concept, mechanism, foods.

Язык: Английский

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Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Фев. 14, 2022

Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, beverages like fruit juices, tea, coffee wine. In recent years, dietary have gained significant interest among researchers due to their potential chemopreventive/protective functions the maintenance of human health diseases. It is believed that polyphenols/flavonoids exert powerful antioxidant action for protection against reactive oxygen species (ROS)/cellular oxidative stress (OS) towards prevention OS-related pathological conditions or Pre-clinical clinical evidence strongly suggest long term consumption diets rich offer development various chronic diseases such as neurodegenerative diseases, cardiovascular (CVDs), cancer, diabetes, inflammatory disorders infectious illness. Increased intake foods containing (for example, quercetin, epigallocatechin-3-gallate, resveratrol, cyanidin etc.) has been claimed reduce extent a majority cellular damage, DNA tissue inflammations, viral/bacterial infections, suggested activity plays pivotal role OS-induced this narrative review, biological/pharmacological significance and/or major cancers, CVDs, diabetes mellitus, delineated. This review specifically focuses current understanding on sources protective effects mechanisms

Язык: Английский

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Phenolic compounds: current industrial applications, limitations and future challenges

Food & Function, Год журнала: 2020, Номер 12(1), С. 14 - 29

Опубликована: Ноя. 5, 2020

Phenolic compounds are natural bioactive molecules found mainly in plant tissues that have shown interesting bioactivities, such as antioxidant, antimicrobial, anti-inflammatory, and antiproliferative activities, among others, which has led to great interest their use by several industries. However, despite the large number of scientific studies on this topic, some issues still need be studied solved, understanding main actions these organisms. Besides potential applicability industry, phenolic face making it necessary develop strategies improve bioavailability, sustainable technologies extraction refinement, stability procedures increase range applicability. This review focuses most recent advances applications different technological medicinal areas. In addition, techniques resourcing, bioavailability will presented discussed.

Язык: Английский

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Extraction of Flavonoids From Natural Sources Using Modern Techniques

Frontiers in Chemistry, Год журнала: 2020, Номер 8

Опубликована: Сен. 25, 2020

Flavonoids are one of the main groups polyphenols found in natural products. Traditional flavonoid extraction techniques being replaced by advanced to reduce energy and solvent consumption, increase efficiency selectivity, meet increased market demand environmental regulations. Advanced technologies, such as microwaves, ultrasound, pressurized liquids, supercritical fluids, electric fields, alternatives currently used. These modern generally faster, more environmentally friendly, with higher automation levels compared conventional techniques. This review will discuss different methods available for from sources parameters involved (temperature, solvent, sample quantity, time, among others). Recent trends their industrial importance also discussed detail, providing insight into potential. Thus, this paper seeks innovations compound techniques, presenting each them advantages disadvantages, trying offer a broader scope understanding plant matrices.

Язык: Английский

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Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Июнь 28, 2021

The genome of gut microbes encodes a collection enzymes whose metabolic functions contribute to the bioavailability and bioactivity unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, other omics have expanded understanding different modes actions by which (poly)phenols modulate microbiome conferring health benefits host. Progress been made identify direct prebiotic effects (poly)phenols; albeit up date, these compounds are not recognized as prebiotics sensu stricto . Interestingly, certain probiotics strains an enzymatic repertoire, such tannase, α-L-rhamnosidase, phenolic acid reductase, involved in transformation into bioactive metabolites. In vivo studies demonstrated that (poly)phenol-transforming bacteria thrive when provided with substrates. However, taxonomically distinct symbionts phenolic-metabolizing activity has still significantly promoted This is case Akkermansia muciniphila , so-called antiobesity bacterium, responds positively may be partially responsible for formerly attributed molecules. We surmise broad antimicrobial action free ecological niches occupied competing bacteria, thereby allowing bloom beneficial bacteria. review explores capacity promote through their collaborative bacterial utilization inhibitory on potential pathogenic species. propose term duplibiotic describe substrate modulating microbiota both action. (Poly)phenol effect could participate blunting disturbance dysbiosis, positioning dietary strategies therapeutic potential.

Язык: Английский

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Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

British Journal of Pharmacology, Год журнала: 2019, Номер 177(6), С. 1227 - 1240

Опубликована: Дек. 4, 2019

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective the market, brief comparison that in China, as an illustration how individual health supplements increase and decrease popularity regional terms. Recent changes sales patterns, mainly taken from US are summarized selection five newer products, which have not been subject extensive recent review profiled: astaxanthin, carotenoid found red algae, seafood, salmon trout, antioxidant; cannabidiol, non-euphoric marijuana ingredient used mood enhancer for painful/inflammatory conditions; modified extracts ginseng new indications including dementia space travel; monk fruit, non-sugar high intensity sweetener nigella seed, popular food Asian medicine, has experienced extraordinary rise recently. LINKED ARTICLES: article part themed section on Pharmacology Nutraceuticals. To view other articles this visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

Язык: Английский

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A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

Critical Reviews in Food Science and Nutrition, Год журнала: 2019, Номер 60(19), С. 3290 - 3303

Опубликована: Ноя. 4, 2019

Quercetin, one of the most taken flavonoid with diet, belongs to family flavonols in which kaempferol and myricetin are also found. Quercetin occurs as a glycoside (with linked sugars) or an aglycone (without sugars). Although quercetin has many different forms nature, form found plants is quercetin-3-O-glucoside, generally functions pigment that gives color multitude fruits vegetables. The recent literature been reviewed using PubMed, Science Direct, Embase databases. In this article, we respect chemical properties, absorption mechanism, metabolism, bioavailability, food sources, bioactivities, possible health-promoting mechanisms. known antioxidant, anti-inflammatory, cardioprotective, anti-obesity compound. It thought be beneficial against cardiovascular diseases, cancer, diabetes, neurological obesity, allergy asthma, atopic diseases. Further clinical studies large sample sizes needed determine appropriate dose for preventing

Язык: Английский

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Tannic acid-based metal phenolic networks for bio-applications: a review

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(20), С. 4098 - 4110

Опубликована: Янв. 1, 2021

Strategic design for the fabrication of tannic acid-based metal phenolic networks. Various applications networks in biomedical fields.

Язык: Английский

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A Brief Review of Phenolic Compounds Identified from Plants: Their Extraction, Analysis, and Biological Activity

Natural Product Communications, Год журнала: 2022, Номер 17(1)

Опубликована: Янв. 1, 2022

Phenolic compounds are the most abundant secondary metabolites in plants, showing a wide range of distinct biological activities, have received more and attention recent years. This review aims to gather systematize available information on phenolic from plants by discussing different types compounds, extraction, analysis methods, with an emphasis their potential activities. The research direction problems that should be paid future also put forward provide some references for further study compounds.

Язык: Английский

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