Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction

Nutrients, Год журнала: 2022, Номер 14(6), С. 1137 - 1137

Опубликована: Март 8, 2022

Growing evidence supports the hypothesis that dietary factors may play a role in systemic low-grade chronic inflammation. Summary from randomized controlled trials has shown substantial effects on biomarkers of inflammation following adoption plant-based diets (including, but not limited to, Mediterranean diet), while consistent findings have been reported for higher intakes whole grains, fruits, and vegetables positive trends observed consumption legumes, pulses, nuts, olive oil. Among animal food groups, dairy products to best benefits inflammation, red meat egg neutral effects. The present review provides an overview mechanisms underlying relation between immune system, with focus specific macronutrient non-nutrient phytochemicals (polyphenols) Substantial differences within each group explain conflicting results obtained regarding foods high saturated fats carbohydrates, subtypes molecules (i.e., short-chain fatty acids or fiber vs. long chain free added sugars) when exploring diet as well importance matrix commixture context patterns. Dietary polyphenols oligopeptides hypothesized exert several functions, including regulation inflammatory response system. Overall, suggests affect system regardless obesity-related

Язык: Английский

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Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3264 - 3264

Опубликована: Март 13, 2024

Oxidative stress, characterized by an imbalance favouring oxidants over antioxidants, is a key contributor to the development of various common diseases. Counteracting these considered effective strategy mitigate levels oxidative stress in organisms. Numerous studies have indicated inverse correlation between consumption vegetables and fruits risk chronic diseases, attributing health benefits presence antioxidant phytochemicals foods. Phytochemicals, present wide range foods medicinal plants, play pivotal role preventing treating diseases induced working as antioxidants. These compounds exhibit potent antioxidant, anti-inflammatory, anti-aging, anticancer, protective properties against cardiovascular diabetes mellitus, obesity, neurodegenerative conditions. This comprehensive review delves into significance averting managing elucidating sources invaluable elements. Additionally, it provides summary recent advancements understanding associated with phytochemicals.

Язык: Английский

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Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability

Compounds, Год журнала: 2023, Номер 3(1), С. 40 - 72

Опубликована: Янв. 5, 2023

Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They widely distributed world and can be found fruits, cereals, tea, coffee, beverages. Due to their structural diversity, polyphenols have many different properties biological effects. resistant acid of gastric tract, very few hydrolysed or absorbed stomach. Significant portions ingested reach large intestine interact with local bacteria, so-called gut microbiota. Epidemiological studies confirm that moderate prolonged intake foods rich could prevent development cancer chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, obesity. The current work aims provide an updated overview on nature occurrence polyphenols, quantification methods, bioaccessibility bioavailability, impact human health, namely through interactions

Язык: Английский

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Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3813 - 3813

Опубликована: Фев. 14, 2023

It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, have chemical structures, and the most representative flavonoids, phenolic acids, stilbenes. should be noted of closely related to their bioavailability bioaccessibility, as many them rapidly metabolized after administration. Polyphenols—with a protective effect gastrointestinal tract—promote maintenance eubiosis intestinal microbiota against gastric colon cancers. Thus, benefits obtained from dietary supplementation would seem mediated by gut microbiota. Taken at certain concentrations, been shown positively modulate bacterial component, increasing Lactiplantibacillus spp. Bifidobacterium involved in protection barrier decreasing Clostridium Fusobacterium, which negatively associated well-being. Based diet–microbiota–health axis, this review aims describe latest knowledge action health through activity discusses micro-encapsulation strategy improve

Язык: Английский

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Effects of Fermentation on Bioactivity and the Composition of Polyphenols Contained in Polyphenol-Rich Foods: A Review

Foods, Год журнала: 2023, Номер 12(17), С. 3315 - 3315

Опубликована: Сен. 3, 2023

Polyphenols, as common components with various functional activities in plants, have become a research hotspot. However, researchers found that the bioavailability and bioactivity of plant polyphenols is generally low because they are usually form tannins, anthocyanins glycosides. Polyphenol-rich fermented foods (PFFs) reported to better than polyphenol-rich foods, used substrates during food fermentation hydrolyzed into smaller phenolic compounds (such quercetin, kaempferol, gallic acid, ellagic etc.) higher by polyphenol-associated enzymes (PAEs, e.g., tannases, esterases, acid decarboxylases glycosidases). Biotransformation pathways different PAEs secreted microorganisms different. Meanwhile, could also promote growth beneficial bacteria process while inhibiting pathogenic bacteria. Therefore, PFFs, there must be an interactive relationship between microorganisms. The present study integration analysis interaction mechanism PFFs systematically elaborated. will provide some new insights explore greater exploitation availability polyphenols) plant-derived foods.

Язык: Английский

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The Impact of Plant Phytochemicals on the Gut Microbiota of Humans for a Balanced Life

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8124 - 8124

Опубликована: Июль 23, 2022

The gastrointestinal tract of humans is a complex microbial ecosystem known as gut microbiota. microbiota involved in several critical physiological processes such digestion, absorption, and related functions plays crucial role determining the host’s health. habitual consumption specific dietary components can impact beyond their nutritional benefits, altering diversity function could manipulate Phytochemicals are non-nutrient biologically active plant that modify composition microflora through selective stimulation proliferation or inhibition certain communities intestine. Plants secrete these components, they accumulate cell wall sap compartments (body) for development survival. These compounds have low bioavailability long time-retention intestine due to poor resulting beneficial impacts on population. Feeding diets containing phytochemicals animals may offer path improve microbiome improved performance and/or health wellbeing. This review discusses effects modulation environment resultant benefits humans; however, effect also covered, brief.

Язык: Английский

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Mediterranean Diet on Sleep: A Health Alliance

Nutrients, Год журнала: 2022, Номер 14(14), С. 2998 - 2998

Опубликована: Июль 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Язык: Английский

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Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Phytomedicine, Год журнала: 2023, Номер 119, С. 154979 - 154979

Опубликована: Июль 18, 2023

Язык: Английский

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The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4834 - 4834

Опубликована: Апрель 29, 2024

The human gut microbiota, an intricate ecosystem within the gastrointestinal tract, plays a pivotal role in health and disease. Prebiotics, non-digestible food ingredients that beneficially affect host by selectively stimulating growth and/or activity of beneficial microorganisms, have emerged as key modulator this complex microbial community. This review article explores evolution prebiotic concept, delineates various types prebiotics, including fructans, galactooligosaccharides, xylooligosaccharides, chitooligosaccharides, lactulose, resistant starch, polyphenols, elucidates their impact on microbiota composition. We delve into mechanisms through which prebiotics exert effects, particularly focusing producing short-chain fatty acids modulating towards health-promoting implications are extensively reviewed, conditions such obesity, inflammatory bowel disease, immune function, mental health. further discusses emerging concept synbiotics—combinations probiotics synergistically enhance health—and highlights market potential response to growing demand for functional foods. By consolidating current knowledge identifying areas future research, aims understanding prebiotics’ underscoring importance maintaining healthy microbiome overall well-being.

Язык: Английский

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The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

Antioxidants, Год журнала: 2023, Номер 12(3), С. 630 - 630

Опубликована: Март 3, 2023

In the past decades, many studies have widely examined effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and chelating abilities, by which they can be potentially employed in cases pathological conditions, such as iron overload. this review, we highlighted abilities polyphenols, due to structural specific sites, differences each class polyphenols. We also explored how iron-binding important inflammatory/immunomodulatory responses, with a special focus involvement macrophages dendritic cells, might contribute reshape gut microbiota into healthy profile. This review provides evidence that axes “polyphenol–iron metabolism–inflammatory responses” availability–gut microbiota” not been very so far, need further investigation exploit potential prevent or counteract conditions.

Язык: Английский

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