Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

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Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome

Journal of Cell Communication and Signaling, Год журнала: 2022, Номер 17(1), С. 55 - 74

Опубликована: Сен. 16, 2022

Язык: Английский

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MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

Redox Biology, Год журнала: 2022, Номер 56, С. 102469 - 102469

Опубликована: Сен. 11, 2022

Язык: Английский

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Research progress on natural β-glucan in intestinal diseases

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 219, С. 1244 - 1260

Опубликована: Сен. 2, 2022

Язык: Английский

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pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(45), С. 50692 - 50709

Опубликована: Ноя. 3, 2022

Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH severely limited by its low water solubility, bioavailability, poor colonic targeting. Although some nanoparticles have been developed oral delivery RH, most them mainly highlighted only one effect drug strategies but above activities. Therefore, polysaccharide-based nanodelivery system, comprising chitosan (CS) fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity mucosal adhesion, was first used load as comprehensive UC. Briefly, RH-F/C-NPs were prepared using polyelectrolyte self-assembly method; average size 233.1 ± 5.7 nm, encapsulation rate 93.67 1.60%. And it could maintain gastric stability release in colon designed pH/ROS contributed structures. Cellular uptake experiments showed that both NCM 460 cells RAW 264.7 had good RH-F/C-NPs. Importantly, effects vivo experiments, results which significantly reduce DSS-induced inflammation inhibiting TLR4/NF-κB-mediated anti-inflammatory pathway, Nrf2/HO-1-mediated antioxidant In addition, pharmacokinetic studies shown F/C-NPs increase plasma concentration accumulation extent. short, this study develop nanosystem dual "one stone four birds" therapeutic on

Язык: Английский

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Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model

Journal of Inflammation Research, Год журнала: 2022, Номер Volume 15, С. 2631 - 2647

Опубликована: Апрель 1, 2022

Background: An animal model of DSS-induced UC has been widely used in basic research, and the dysbiosis gut microbiome is one important pathogenetic mechanisms UC, but its dynamic changes correlation with inflammatory factors are not clear yet. Methods: Clinical signs tissue damage degree C57BL/6 ulcerative colitis mice induced by different concentrations DSS were compared that normal mice, finally optimal concentration was determined. Then we analyzed sequencing results to determine patterns their factors. Results: at 2.5% 3.0% could cause intestinal injury induce colitis. However, resulted higher mortality. In addition, there model: relative abundance flora increased first then decreased Bacteroides , Parabacteroides Romboutsia Clostridium_sensu_stricto_1, Lachnospiraceae_NK4A136_group, norank_f_norank_o_Clostridia_UCG-014, Parasutterella Lactobacillus Muribaculum norank_f_Muribaculaceae, Bifidobacterium Coriobacteriaceae_UCG-002 Enterorhabdus did change 14 days significantly on day 21. Moreover, cytokines closely associated imbalance microbiota UC: most pathogenic bacteria tract positively correlated pro-inflammatory negatively anti-inflammatory factors, while beneficial opposite. Conclusion: Intestinal microecology plays an role model, dynamically occurrence development Keywords: colitis, DSS, microbiome, changes, 16S rDNA

Язык: Английский

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Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 11004 - 11004

Опубликована: Июль 2, 2023

Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn's (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD offers promising strategies for remedies. A brief overview the variations occurring in during presented, role gut microbiota barrier maintenance, immune metabolic regulation, absorption supply nutrients reviewed. More importantly, we review drug research on past ten years, including clinical natural drugs, well adjuvant therapies, such Fecal Microbiota Transplantation probiotic supplements. We also summarize interventions mechanisms these drugs microbiota.

Язык: Английский

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Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Brain Sciences, Год журнала: 2024, Номер 14(3), С. 238 - 238

Опубликована: Фев. 29, 2024

Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis examined. In addition, intestinal inflammation, serum fecal short-chain fatty acids (SCFAs) analyses, assessed. We found treatment effectively inhibited reduction neurons substantia nigra pars compacta (SNpc) partially improved motor function mice. Additionally, markedly alleviated neuroinflammation striatum hippocampus promoted hippocampal neurogenesis. It also level colon inflammation. Furthermore, these aforementioned changes are mainly accompanied by alterations isovaleric acid levels, lower permeability. strongly neuroprotective agent therapy.

Язык: Английский

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Red/NIR‐I‐Fluorescence Carbon Dots Based on Rhein with Active Oxygen Scavenging and Colitis Targeting for UC Therapeutics

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Март 19, 2024

Ulcerative colitis (UC) is a chronic inflammatory disease with uncontrolled inflammation and demage to the intestinal barrier. Rhein, bioactive compound in traditional Chinese medicine, has anti-inflammatory repair effect. However, their clinical application limited by hydrophobicity poor bioavailability. L-arginine, as complement NO, synergistic attenuating effects. In this paper, red/NIR-I fluorescent carbon dots based on rhein doped L-arginine (RA-CDs), which are synthesized hydrothermal process without any organic solvents, reported. RA-CDs preserve portion of functional group active precursor, increase solubility, emit light for biological imaging. vitro experiments show that scavenge excessive reactive oxygen species (ROS), protect cells from oxidative stress, enable fluorescence imaging inflamed colons. DSS-induced UC mouse model, both delayed prophylactic treatment via intraperitoneal tail vein injections alleviate severity reducing restoring This study highlights novel strategy treating poorly soluble small-molecule drugs.

Язык: Английский

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Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 30, 2024

The specific pathogenesis of UC is still unclear, but it has been clear that defects in intestinal barrier function play an important role it. There a temporary lack drugs for clinical treatment. Astragaloside IV (AS-IV) one the main active ingredients extracted from Astragalus root and common Chinese herbal medicine treatment gastrointestinal diseases. This study aimed to determine whether AS-IV therapeutic value DSS or LPS-induced epithelial dysfunction vivo vitro its potential molecular mechanisms.

Язык: Английский

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