Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 19, 2025
Язык: Английский
Carbohydrate Polymers, Год журнала: 2023, Номер 311, С. 120718 - 120718
Опубликована: Фев. 25, 2023
Язык: Английский
Процитировано
41
Food Chemistry Molecular Sciences, Год журнала: 2024, Номер 8, С. 100198 - 100198
Опубликована: Март 12, 2024
Curcumin, a polyphenol natural product derived from turmeric, possesses diverse pharmacological effects due to its interactions with various cells and molecules. Recent studies have highlighted immunomodulatory properties, including impact on immune mediators involved in responses. Th17 play crucial role promoting responses against extracellular pathogens by recruiting neutrophils inducing inflammation. These produce inflammatory cytokines such as TNF-α, IL-21, IL-17A, IL-23, IL-17F, IL-22, IL-26. Curcumin has been shown significantly inhibit the proliferation of reduce production cytokines, IL-17. This review aims assess effectiveness curcumin underlying mechanisms modulating cells.
Язык: Английский
Процитировано
11
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
In recent years, immunotherapy has become a novel antitumor strategy in addition to traditional surgery, radiotherapy, and chemotherapy exhibited promising results clinical applications. Despite significant breakthroughs immunotherapy, such as immune checkpoint blockade CAR-T cell therapy, it remains necessary develop more efficacious, safer, cheaper immunotherapeutic drugs due factors including small reaction populations, acquired resistance, adverse side effects, high costs. Natural killer (NK) cells are preeminent cytotoxic lymphocytes of the innate system that act first line defense against tumors synergistically enhance adaptive response T lymphocytes. Therefore, boosting function NK is an important direction development immunotherapy. For decades, various immunotherapies adoptive antibody drugs, cytokines supplement, chemical immunomodulators have been developing rapidly improve cells. Compared biological derived from natural products outstanding advantages low immunogenicity, multi-targeting, cost-effectiveness. Currently, increasing attention being focused on discovering cell-stimulating agents products, polysaccharides, alkaloids, terpenoids, saponins, phenolics, quinones. This review aims categorize summarize comprehensive research progress these discuss their potential molecular mechanisms regulating cells, explore applications standalone treatments or combination with conventional regimens.
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105040 - 105040
Опубликована: Окт. 5, 2023
Язык: Английский
Процитировано
18
Clinical and Translational Medicine, Год журнала: 2024, Номер 14(5)
Опубликована: Май 1, 2024
Abstract Background Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target. Over the past few decades, number of available nuclear export‐selective inhibitors has been increasing. Only KPT‐330 (selinexor) successfully used for treating haematological malignancies, KPT‐8602 (eltanexor) haematologic tumours clinical trials. However, use inhibition expression yet to be thoroughly investigated studies outcomes solid tumours. Methods We collected numerous literatures explain efficacy Inhibitors preclinical wide range Results In this review, we focus on export function results from trials its malignant summarized mechanism action potential inhibitors, as well adverse effects response biomarkers. Conclusion emerged promising strategy fight against cancer, offering novel approach targeting tumorigenic processes overcoming SINE compounds have demonstrated tumours, ongoing research focused optimizing their use, identifying biomarkers, developing effective combination therapies. Key Points (XPO1) plays critical role mediating nucleocytoplasmic transport cell cycle. dysfunction promotes tumourigenesis resistance within The researches treatment Additional are essential address safety concerns identify biomarkers predicting patient inhibitors.
Язык: Английский
Процитировано
7
Medicinal Research Reviews, Год журнала: 2024, Номер 44(6), С. 2793 - 2824
Опубликована: Июль 19, 2024
Nanoparticles (NPs) that target multiple transport mechanisms facilitate targeted delivery of active therapeutic agents to the central nervous system (CNS) and improve efficacy across blood-brain barrier (BBB). CNS nanotherapeutics mostly neurons endothelial cells, however, microglial immune cells are first line defense against neuronal damage brain infections. Through triggering release inflammatory cytokines, chemokines proteases, microglia can however precipitate neurological damage-a significant factor in neurodegenerative diseases. Thus, inhibitory attracting much attention among those researching developing novel treatments for disorders. The most established inhibitors investigated date resveratrol, curcumin, quercetin, minocycline. there is great interest bypass or easily cross BBB. One such approach use modified-nanocarriers as, for, of, wider CNS. For inhibition, polymeric NPs preferred vehicles choice. Here, we summarize immunologic neuroinflammatory role microglia, inhibitor agents, challenges drug delivery, explored inhibition date. We also discuss applications currently considered "most useful" microglial-inhibitor CNS-related
Язык: Английский
Процитировано
7
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
7
BioFactors, Год журнала: 2024, Номер 50(4), С. 634 - 673
Опубликована: Янв. 2, 2024
Abstract With the rising prevalence of diabetes and its association with cognitive impairment, interest in use dietary alkaloids other natural products has grown significantly. Understanding how these compounds manage diabetic dysfunction (DCD) is crucial. This comprehensive review explores etiology DCD effects foods supplements that have been investigated as therapies. Data on like berberine, trigonelline, caffeine, capsaicin, 1‐deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, others regulate cognition disorders were collected from PubMed, Research Gate, Web Science, Science Direct, relevant databases. Dietary could improve memory behavioral models modulate mechanisms underlying benefits compounds, including their glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, oxidative stress. Evidence suggests hold promise for improving patients open exciting avenues future research management.
Язык: Английский
Процитировано
5
ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(2), С. 300 - 308
Опубликована: Янв. 9, 2024
Curcumin, a polyphenol compound that belongs to class of molecules known as curcuminoids, may interact with various biological macromolecules in the body, including proteins, nucleic acids, and lipids. Curcumin-based fixed-dose combination (FDC) products enhance curcumin stability bioavailability for better clinical use cholesterol management. Preclinical studies on are mostly positive. Obstacles variable composition many different curcumin-based FDC products, lack standards, limitation randomized controlled trials (RCTs) conducted specific products. Once these downfalls have been addressed, great potential They can supplement uptake statins, reducing their dosage same controlling effects or even replacing them.
Язык: Английский
Процитировано
5
Cancer Letters, Год журнала: 2024, Номер 593, С. 216955 - 216955
Опубликована: Май 14, 2024
Язык: Английский
Процитировано
5