Food Science & Nutrition,
Год журнала:
2024,
Номер
12(12), С. 9951 - 9973
Опубликована: Ноя. 7, 2024
ABSTRACT
Understanding
the
molecular
signaling
pathways
of
colorectal
cancer
(CRC)
can
be
accepted
as
first
step
in
treatment
strategy.
Permanent
mTOR
activation
stimulates
CRC
process
via
various
biological
processes.
It
supplies
survival
stem
cells,
tumorigenesis,
morbidity,
and
decreased
response
to
drugs
pathogenesis.
Therefore,
inhibition
by
numerous
bioactive
components
may
effective
against
CRC.
The
study
aims
discuss
therapeutic
capacity
polyphenols,
terpenoids,
alkaloids
on
PI3K/Akt/mTOR
pathway.
potential
effects
compounds
pathway's
upstream
downstream
targets
are
examined.
Each
component
causes
physiological
processes,
such
triggering
free
radical
production,
disruption
mitochondrial
membrane
potential,
cell
cycle
arrest,
migration,
suppression
glycolysis
through
inhibition.
As
a
result,
carcinogenesis
is
inhibited
inducing
apoptosis
autophagy.
However,
it
should
noted
that
studies
primarily
vitro
dose‐dependent
researchers.
This
raises
awareness
about
role
phenolic
treating
CRC,
contributing
their
future
use
anticancer
agents.
These
have
developed
into
food
supplementation
prevent
treat
types
including
review
has
lead
further
development
clinical
studies.
In
future,
applying
several
agents
using
advanced
drug
delivery
systems
contribute
with
3D
culture
vivo
Advances in Pharmacological and Pharmaceutical Sciences,
Год журнала:
2024,
Номер
2024, С. 1 - 11
Опубликована: Фев. 12, 2024
The
primary
reason
for
cancer-related
fatalities
is
metastasis.
compound
4-carbomethoxyl-10-epigyrosanoldie
E,
derived
from
the
Sinularia
sandensis
soft
coral
species
grown
in
cultures,
exhibits
properties
that
counteract
inflammation.
Moreover,
it
has
been
observed
to
trigger
both
apoptosis
and
autophagy
within
cancerous
cells.
This
research
focuses
on
examining
inhibitory
impact
of
E
migration
invasion
processes
Cal-27
Ca9-22
oral
cancer
cell
lines.
To
assess
how
this
affects
invasion,
Boyden
chamber
assay
was
employed.
Furthermore,
Western
blot
analysis
utilized
explore
underlying
molecular
mechanisms.
In
a
dose-dependent
manner,
notably
decreased
levels
matrix
metalloproteinase-2
(MMP-2)
MMP-9,
along
with
urokinase-type
plasminogen
activator
(uPA),
Conversely,
elevated
concentrations
tissue
inhibitors
metalloproteinases-1
(TIMP-1)
TIMP-2.
addition,
treatment
led
inhibition
phosphorylation
extracellular
signal-regulated
kinase
(ERK),
p38,
c-Jun
N-terminal
(JNK).
It
also
curtailed
expression
several
key
proteins
including
focal
adhesion
(FAK),
protein
C
(PKC),
growth
factor
receptor-bound
2
(GRB2),
Rac,
Ras,
Rho
A,
mitogen-activated
3
(MEKK3),
7
(MKK7).
IQ-domain
GTPase-activating
1
(IQGAP1)
zonula
occludens-1
(ZO-1)
were
significantly
reduced
by
compound.
ability
inhibit
cells
be
dose
dependent.
effect
primarily
attributed
suppression
MMP-2
MMP-9
expression,
as
well
downregulation
(MAPK)
signaling
pathway.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11656 - 11656
Опубликована: Окт. 30, 2024
Osteoarthritis
(OA)
is
the
most
common
and
debilitating
form
of
arthritis.
Current
therapies
focus
on
pain
relief
efforts
to
slow
disease
progression
through
a
combination
drug
non-drug
treatments.
Bioactive
compounds
derived
from
plants
show
significant
promise
due
their
anti-inflammatory,
antioxidant,
tissue-protective
properties.
These
natural
can
help
regulate
inflammatory
processes
metabolic
pathways
involved
in
OA,
thereby
alleviating
symptoms
potentially
slowing
progression.
Investigating
efficacy
these
agents
treating
osteoarthritis
addresses
growing
demand
for
health
solutions
creates
new
opportunities
managing
this
increasingly
prevalent
age-related
condition.
The
aim
review
provide
an
overview
use
some
bioactive
modulating
associated
pain.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(46), С. 25743 - 25754
Опубликована: Ноя. 7, 2024
Curcumin
(CUR)
as
one
of
the
natural
edible
pigments
is
approved
by
World
Health
Organization
due
to
its
nontoxic
and
anticancer
effect.
However,
utility
CUR
restricted
low
oral
bioavailability.
Nanoparticle
drug
delivery
systems
like
mesoporous
silica
nanoparticles
(MSNs)
have
been
extensively
used
their
high
specific
surface
area,
loading
rate,
ease
modification.
This
study
developed
lactobionic
acid
(LA)-modified
carboxymethyl
chitosan
(CMCS)-coated
MSNs
deliver
specifically
targeting
hepatocellular
carcinoma.
Among
these
nanoparticles,
LA
targets
liver
cancer
cells.
CMCS
utilizes
pH-responsive
release
CUR.
The
LA-CMCS-MSN@CUR
(MSN@CUR)
were
evaluated
using
several
methods,
including
Fourier
transform
infrared
spectroscopy,
transmission
electron
microscopy,
zeta
potential
measurements.
Liver
cellular
uptake
MSN@CUR
depends
on
a
receptor-mediated
endocytosis
mechanism.
Additionally,
performed
with
better
antitumor
effect
than
Cur
in
H22
orthotopic
transplantation
solid
tumor
mouse
models.
Treatment
significantly
reduced
protein
VEGF,
p-PI3K,
AKT,
increased
caspases
3
8,
ultimately
inhibited
migration,
promoted
apoptosis.
provides
new
path
for
active
ingredients
excellent
bioavailability
field.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(12), С. 9951 - 9973
Опубликована: Ноя. 7, 2024
ABSTRACT
Understanding
the
molecular
signaling
pathways
of
colorectal
cancer
(CRC)
can
be
accepted
as
first
step
in
treatment
strategy.
Permanent
mTOR
activation
stimulates
CRC
process
via
various
biological
processes.
It
supplies
survival
stem
cells,
tumorigenesis,
morbidity,
and
decreased
response
to
drugs
pathogenesis.
Therefore,
inhibition
by
numerous
bioactive
components
may
effective
against
CRC.
The
study
aims
discuss
therapeutic
capacity
polyphenols,
terpenoids,
alkaloids
on
PI3K/Akt/mTOR
pathway.
potential
effects
compounds
pathway's
upstream
downstream
targets
are
examined.
Each
component
causes
physiological
processes,
such
triggering
free
radical
production,
disruption
mitochondrial
membrane
potential,
cell
cycle
arrest,
migration,
suppression
glycolysis
through
inhibition.
As
a
result,
carcinogenesis
is
inhibited
inducing
apoptosis
autophagy.
However,
it
should
noted
that
studies
primarily
vitro
dose‐dependent
researchers.
This
raises
awareness
about
role
phenolic
treating
CRC,
contributing
their
future
use
anticancer
agents.
These
have
developed
into
food
supplementation
prevent
treat
types
including
review
has
lead
further
development
clinical
studies.
In
future,
applying
several
agents
using
advanced
drug
delivery
systems
contribute
with
3D
culture
vivo
