Research on catalytic application of Fe3O4@AAPA-AP-CuCl2 nanocomposite: First nanomagnetic copper catalyst for preparation of aryl nitriles from aldehydes
Journal of Molecular Structure,
Год журнала:
2023,
Номер
1296, С. 136800 - 136800
Опубликована: Окт. 11, 2023
Язык: Английский
“In-Water” Three-Component One-Pot Reaction for the Facile Synthesis of Densely Functionalized 2,3-Dihydro-1H-pyrrol-2-ols and Mechanistic Insight
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(35), С. 13336 - 13351
Опубликована: Авг. 22, 2024
An
environmentally
friendly
multicomponent
reaction
strategy
for
the
synthesis
of
functionally
rich
all-carbon
substituted
2,3-dihydro-1H-pyrrol-2-ols
"in-water"
at
room
temperature
has
been
reported.
Water
plays
an
indispensable
role
in
presence
readily
available
catalytic
surfactants
sodium
dioctylsulfosuccinate
and
dodecyl
sulfate
to
effectuate
transformation,
as
proved
by
inferior
results
obtained
organic
solvents.
A
wide
display
substrate
scope
functional
group
compatibility
permits
diversity
generation
a
mild
operationally
simple
fashion.
High
product
yields,
fast
rate,
recoverability/recyclability
catalysts,
high
TON/TOF,
ease
purification
final
products
filtration,
AE
values,
excellent
E-factor
count
with
score
low
possible
highlight
"greenness"
this
approach.
Feasibility
"gram-scale"
synthetic
elaboration
offer
notable
advantages.
The
mechanistic
understanding
intercepting
labile
"imine"
intermediate
realized
through
sequence
imine
formation
Mannich-type
followed
intramolecular
N-cyclization.
Язык: Английский
Asymmetric [5+1] Annulation via C–H Activation/1,4-Rh Migration/Double Bond Shift Using a Transformable Pyridazine Directing Group
Organic Letters,
Год журнала:
2023,
Номер
25(11), С. 1839 - 1844
Опубликована: Март 13, 2023
N-Heterocycle-assisted
C-H
activation/annulation
reactions
have
provided
new
concepts
for
the
construction
and
transformation
of
azacycles.
In
this
work,
we
disclose
a
[5+1]
annulation
reaction
using
novel
transformable
pyridazine
directing
group
(DG).
The
DG-transformable
mode
led
to
heterocyclic
ring
accompanied
by
original
via
activation/1,4-Rh
migration/double
bond
shift
pathway,
affording
skeleton
pyridazino[6,1-b]quinazolines
with
good
substrate
scope
under
mild
conditions.
Diverse
fused
cyclic
compounds
can
be
achieved
derivatization
product.
asymmetric
synthesis
was
also
realized
afford
enantiomeric
products
stereoselectivity.
Язык: Английский
Research on the catalytic activity of MNP-[Dop-OH]-CuBr2 nanocomposites: novel and stable reusable nanocatalysts for the synthesis of 1,3,5-triazine derivatives
Shouchun Feng,
Jinwang Tan,
Yufan Ma
и другие.
RSC Advances,
Год журнала:
2023,
Номер
13(24), С. 16078 - 16090
Опубликована: Янв. 1, 2023
In
recent
years,
magnetic
nanocatalysts
have
been
recommended
as
one
of
the
best
catalysts
by
chemists.
Among
nanoparticles,
Fe3O4
nanoparticles
are
highly
suitable
due
to
their
properties,
chemical
stability
and
low
toxicity.
These
can
be
separated
via
separation
after
process
is
over
reused
regeneration.
Owing
importance
1,3,5-triazine
derivatives
in
pharmaceutical
medicinal
chemistry,
synthesis
these
compounds
always
important
goals
organic
this
research
work,
we
first
successfully
synthesized
CuBr2
immobilized
on
functionalized
with
Dop-OH
(prepared
reaction
MNP-dopamine
2-phenyloxirane)
nanocomposites
then
investigated
catalytic
application
an
oxidative
coupling
amidine
hydrochlorides
alcohols
air.
Recycling
experiments
clearly
revealed
that
MNP-[Dop-OH]-CuBr2
could
for
at
least
8
times
without
much
loss
activity.
Язык: Английский
Construction of Nitrogen Spirocycles in a Tandem Co(III)‐catalyzed C−H Activation/Dipolar Cycloaddition Reaction
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(23), С. 4241 - 4247
Опубликована: Окт. 30, 2023
Abstract
Complex
spirocyclic
isoindolines
and
pyrrolidines
are
formed
in
a
tandem
process
involving
Co(III)‐catalyzed
dienylation
of
cyclic
C‐aryl
nitrones
with
2,3‐butadien‐1‐ol
carbonates,
followed
by
intramolecular
1,3‐dipolar
cycloaddition.
The
nitrone
moiety
serves
both
as
directing
group
for
the
C(aryl)−H
activation
dipole
cycloaddition
step.
High
regioselectivity
fused
vs.
bridged
product
can
be
obtained
adjusting
reaction
temperature.
Reactions
substituted
allenic
substrates
provide
heterocycles
additional
stereocenters
usually
complete
diastereoselectivity.
products
were
readily
transformed
further
into
other
complex
nitrogen‐containing
systems.
Язык: Английский
Dirhodium-Catalyzed Transannulation ofN-Sulfonyl-1,2,3-triazoles to 2,3-Dehydropiperazines
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(16), С. 11968 - 11979
Опубликована: Июль 31, 2023
The
dirhodium(II)-catalyzed
synthesis
of
a
range
C2-substituted
2,3-dehydropiperazines
using
1-mesyl-1,2,3-triazoles
and
β-haloalkylcarbamates
is
reported.
reaction
proposed
to
proceed
through
an
α-imino
rhodium
carbene
1,3-insertion
into
N-H
followed
by
base-mediated
cyclization.
C-Substituted
dehydropiperazines
can
also
be
conducted
directly
from
terminal
alkynes
in
three-step,
one-pot
operation,
forming
the
triazole
situ.
This
methodology
has
been
expanded
afford
several
2,5-disubstituted
as
well
larger
4,5,6,7-tetrahydro-1H-1,4-diazepine
derivative.
Язык: Английский
Advances in Selected Heterocyclization Methods
Synlett,
Год журнала:
2023,
Номер
34(13), С. 1554 - 1562
Опубликована: Март 10, 2023
Abstract
This
Account
summarizes
efforts
in
our
group
toward
synthesis
of
heterocycles
the
past
decade.
Selected
examples
transannulative
heterocyclizations,
intermediate
construction
reactive
compounds
en
route
to
these
important
motifs,
and
newer
developments
a
radical
approach
are
outlined.
1
Introduction
2
Transannulative
Heterocyclization
2.1
Rhodium-Catalyzed
2.2
Copper-Catalyzed
3
Synthesis
Heterocycles
from
Reactive
Precursors
3.1
Diazo
Compounds
3.2
Alkynones
4
Radical
4.1
Light-Induced
4.2
Light-Free
7
Conclusion
Язык: Английский
Recent Breakthroughs in Ring-Opening Annulation Reactions of Aziridines
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Aziridine
is
a
fascinating
core
which
enables
synthesis
of
diverse
N-heterocycles
comprising
natural
product
analogs
and
pharmaceutical
candidates.
Язык: Английский
Synthesis of 2,4‐dihydrochromeno[3,4‐d][1,2,3]triazoles and 5‐(2H‐chromen‐3‐yl)‐1H‐tetrazoles via regioselective 1,3‐dipolar cycloaddition of 2H‐chromene‐3‐carbonitriles with NaN3
ChemistrySelect,
Год журнала:
2022,
Номер
7(46)
Опубликована: Дек. 8, 2022
Abstract
Conjugated
cyano
cyclo‐olefins
modified
as
highly
regioselective
dipolarophiles
in
1,3‐dipolar
cycloaddition
with
NaN
3
to
synthesize
corresponding
fused
1,2,3‐triazole
and
1
H
‐tetrazole
derivatives.
The
first
example
of
catalytic
2
‐chromene‐3‐carbonitriles
subsequent
elimination/cyclization
functionality
is
designated.
In
presence
amount
p
‐TSA
or
AgNO
,
react
discretely
producing
2,4‐dihydrochromeno[3,4‐d][1,2,3]triazoles
5‐(2
‐chromen‐3‐yl)‐1
‐tetrazoles
respectively,
good
excellent
yields
(i.
e.
51–88
%
85–97
%)
high
regioselectivity
wide
substrate
scope
adequacy.
Язык: Английский
Ru(II)-Catalyzed One-Pot Synthesis of 1,2-Hydropyridines via a Three-Component Reaction
Organic Letters,
Год журнала:
2023,
Номер
25(9), С. 1476 - 1480
Опубликована: Март 1, 2023
A
ruthenium(II)-catalyzed
one-pot
synthesis
of
highly
substituted
1,2-dihydropyridines
(DHPs)
via
a
three-component
reaction
system
has
been
realized.
The
is
conducted
using
simple
Ru(II)
catalyst
without
the
addition
specific
ligands.
catalytic
exhibits
good
functionality
tolerance
with
wide
range
starting
materials.
DHPs
obtained
can
be
easily
converted
into
tetrahydropyridines
and
azabicyclo[4.2.0]octa-4,7-dienes
by
subsequent
reduction
or
[2
+
2]
cycloaddition
reaction.
Язык: Английский