Controlled release of dasatinib from cyclodextrin-based inclusion complexes by mechanochemistry: A computational and experimental study
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125552 - 125552
Опубликована: Апрель 1, 2025
Язык: Английский
Biopharmaceutical Characterization and Stability of Nabumetone–Cyclodextrins Complexes Prepared by Grinding
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1493 - 1493
Опубликована: Ноя. 21, 2024
Background:
Nabumetone
(NAB)
is
a
poorly
soluble
nonsteroidal
anti-inflammatory
prodrug
(BCS
class
II
drug)
whose
solubility
significantly
improved
by
complexation
with
cyclodextrins
(CDs).
Methods:
The
solid
complexes,
in
1:1
molar
ratio,
were
prepared
mechanochemical
activation
grinding,
using
β-cyclodextrin
(β-CD)
and
its
derivatives,
hydroxypropyl-
sulfobutylether-β-cyclodextrin
(HP-β-CD
SBE-β-CD).
was
confirmed
differential
scanning
calorimetry
(DSC),
powder
X-ray
diffraction
(PXRD),
attenuated
total
reflectance
Fourier-transformed
infrared
spectroscopy
(ATR–FTIR).
Obtained
products
further
characterized
regarding
their
solubility,
vitro
dissolution,
permeability
chemical
stability.
Results:
Co-grinding
HP-β-CD
SBE-β-CD
yielded
that
showed
dissolution
profiles
hydrochloric
acid
medium
(pH
1.2)
substantially
different
from
of
pure
NAB,
yielding
efficiency
enhancements
34.86
±
1.64
58.30
0.28
times,
respectively,
for
the
optimized
products.
Their
gastrointestinal
also
studied
low-volume
environment
at
pH
6.8,
corresponding
to
intestinal
environment.
Both
β-CD
derivatives
increased
NAB
rate
mass
transport
across
biomimetic
membrane.
effect
on
stability
under
stress
conditions
developed
validated
UHPLC–DAD–HRMS
method.
In
acidic
conditions,
complexed
prone
hydrolytic
degradation,
one
degradation
product—pharmacologically
inactive
metabolite.
However,
oxidative
elevated
temperatures,
10
identified
co-ground
samples.
All
systems
stable
during
photo-
long-term
studies.
Conclusions:
complexes
are
promising
candidates
pharmaceutical
product
development.
Язык: Английский
The Mechanochemical and Supercritical Fluid Synthesis of β-Cyclodextrin-Hesperidin Inclusion Complex: A Comparison Green Chemistry versus Lyophilization
The Journal of Supercritical Fluids,
Год журнала:
2024,
Номер
215, С. 106422 - 106422
Опубликована: Окт. 3, 2024
Язык: Английский