Controlled release of dasatinib from cyclodextrin-based inclusion complexes by mechanochemistry: A computational and experimental study

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125552 - 125552

Published: April 1, 2025

Language: Английский

Biopharmaceutical Characterization and Stability of Nabumetone–Cyclodextrins Complexes Prepared by Grinding

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1493 - 1493

Published: Nov. 21, 2024

Background: Nabumetone (NAB) is a poorly soluble nonsteroidal anti-inflammatory prodrug (BCS class II drug) whose solubility significantly improved by complexation with cyclodextrins (CDs). Methods: The solid complexes, in 1:1 molar ratio, were prepared mechanochemical activation grinding, using β-cyclodextrin (β-CD) and its derivatives, hydroxypropyl- sulfobutylether-β-cyclodextrin (HP-β-CD SBE-β-CD). was confirmed differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), attenuated total reflectance Fourier-transformed infrared spectroscopy (ATR–FTIR). Obtained products further characterized regarding their solubility, vitro dissolution, permeability chemical stability. Results: Co-grinding HP-β-CD SBE-β-CD yielded that showed dissolution profiles hydrochloric acid medium (pH 1.2) substantially different from of pure NAB, yielding efficiency enhancements 34.86 ± 1.64 58.30 0.28 times, respectively, for the optimized products. Their gastrointestinal also studied low-volume environment at pH 6.8, corresponding to intestinal environment. Both β-CD derivatives increased NAB rate mass transport across biomimetic membrane. effect on stability under stress conditions developed validated UHPLC–DAD–HRMS method. In acidic conditions, complexed prone hydrolytic degradation, one degradation product—pharmacologically inactive metabolite. However, oxidative elevated temperatures, 10 identified co-ground samples. All systems stable during photo- long-term studies. Conclusions: complexes are promising candidates pharmaceutical product development.

Language: Английский

The Mechanochemical and Supercritical Fluid Synthesis of β-Cyclodextrin-Hesperidin Inclusion Complex: A Comparison Green Chemistry versus Lyophilization

The Journal of Supercritical Fluids, Journal Year: 2024, Volume and Issue: 215, P. 106422 - 106422

Published: Oct. 3, 2024

Language: Английский