Abstract
Multiple
biological
barriers
must
be
considered
in
the
design
of
nanomedicines,
including
prolonged
blood
circulation,
efficient
accumulation
at
target
site,
effective
penetration
into
tissue,
selective
uptake
nanoparticles
cells,
and
successful
endosomal
escape.
However,
different
particle
sizes,
surface
chemistries,
sometimes
shapes
are
required
to
achieve
desired
transport
properties
each
step
delivery
process.
In
response,
this
review
highlights
recent
developments
switchable
whose
size,
chemistry,
shape,
or
a
combination
thereof
can
altered
as
function
time,
disease‐specific
microenvironment,
and/or
via
an
externally
applied
stimulus
enable
improved
optimization
nanoparticle
The
practical
use
such
chemotherapy,
bioimaging,
photothermal
therapy,
other
applications
is
also
discussed.
Materials & Design,
Год журнала:
2023,
Номер
229, С. 111917 - 111917
Опубликована: Апрель 7, 2023
Timely
and
accurate
assessment
of
wounds
during
the
wound
healing
process
is
key
for
correct
diagnosis
treatment
decisions
repair.
However,
traditional
management
strategies
often
fail
to
provide
timely
information
on
status,
thereby
delaying
or
misleading
treatments.
Smart
dressings
that
enable
in
situ
real-time
monitoring
wound-related
biomarkers,
early
on-demand
adverse
events,
such
as
bacterial
infection
inflammation,
by
integrating
wearable
sensors,
advanced
drug
delivery
systems
wireless
communication
technology
have
recently
been
developed
could
improve
management.
In
this
review,
we
provided
an
overview
including
temperature,
pH,
uric
acid,
glucose,
reactive
oxygen
(ROS),
enzymes,
related
events
exiting
sensors
detecting
these
biomarkers
based
colorimetric,
fluorimetric
electrochemical
approaches.
Examples
smart
integrate
controllable
functions
triggered
both
endogenous
exogenous
stimuli,
all-in-one
dressing
capable
treatment,
major
challenges
exciting
opportunities
are
presented
comprehensively
discussed.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(24)
Опубликована: Март 9, 2023
Conventional
photocages
only
respond
to
short
wavelength
light,
which
is
a
significant
obstacle
developing
efficient
phototherapy
in
vivo.
The
development
of
activated
by
near-infrared
(NIR)
light
at
wavelengths
from
700
950
nm
important
for
vivo
studies
but
remains
challenging.
Herein,
we
describe
the
synthesis
photocage
based
on
ruthenium
(Ru)
complex
with
NIR
light-triggered
photocleavage
reaction.
commercial
anticancer
drug,
tetrahydrocurcumin
(THC),
was
coordinated
RuII
center
create
Ru-based
that
readily
responsive
760
nm.
inherited
properties
THC.
As
proof-of-concept,
further
engineered
self-assembled
photocage-based
nanoparticle
system
amphiphilic
block
copolymers.
Upon
exposure
nm,
Ru
complex-based
were
released
polymeric
nanoparticles
and
efficiently
inhibited
tumor
proliferation
Antibiotics,
Год журнала:
2023,
Номер
12(2), С. 351 - 351
Опубликована: Фев. 8, 2023
The
effective
prevention
and
treatment
of
bacterial
infections
is
imperative
to
wound
repair
the
improvement
patient
outcomes.
In
recent
years,
nanomaterials
have
been
extensively
applied
in
infection
control
healing
due
their
special
physiochemical
biological
properties.
Incorporating
antibacterial
into
dressing
has
associated
with
improved
biosafety
enhanced
outcomes
compared
naked
nanomaterials.
this
review,
we
discuss
progress
application
nanomaterial-based
dressings
for
advanced
management
infected
wounds.
Focus
given
therapy
as
well
all-in-one
detection
infections.
Notably,
highlight
use
nanoparticles
intrinsic
performances,
such
metals
metal
oxide
that
are
capable
killing
bacteria
reducing
drug-resistance
through
multiple
antimicrobial
mechanisms.
addition,
proven
be
ideal
drug
carriers
delivery
release
antimicrobials
either
passive
or
stimuli-responsive
manners.
ability
kill
based
on
photo-triggered
heat
(photothermal
therapy)
ROS
(photodynamic
therapy),
unparalleled
advantages
control.
Moreover,
examples
intelligent
can
detect
in-situ
while
providing
timely
Finally,
challenges
current
provide
further
perspectives
future
healing.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15352 - 15352
Опубликована: Окт. 19, 2023
Ocular
diseases
profoundly
impact
patients’
vision
and
overall
quality
of
life
globally.
However,
effective
ocular
drug
delivery
presents
formidable
challenges
within
clinical
pharmacology
biomaterial
science,
primarily
due
to
the
intricate
anatomical
physiological
barriers
unique
eye.
In
this
comprehensive
review,
we
aim
shed
light
on
features
eye,
emphasizing
natural
it
administration.
Our
goal
is
provide
a
thorough
overview
various
characteristics
inherent
each
nano-based
system.
These
encompass
nanomicelles,
nanoparticles,
nanosuspensions,
nanoemulsions,
microemulsions,
nanofibers,
dendrimers,
liposomes,
niosomes,
nanowafers,
contact
lenses,
hydrogels,
microneedles,
innovative
gene
therapy
approaches
employing
techniques.
We
delve
into
biology
methodology
these
systems,
introducing
their
applications
over
past
decade.
Furthermore,
discuss
advantages
illuminated
by
recent
studies.
While
systems
for
ophthalmic
formulations
are
gaining
increasing
attention,
further
research
imperative
address
potential
safety
toxicity
concerns.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 636 - 636
Опубликована: Янв. 30, 2024
In
recent
years,
nanocarriers
have
played
an
ever-increasing
role
in
clinical
and
biomedical
applications
owing
to
their
unique
physicochemical
properties
surface
functionalities.
Lately,
much
effort
has
been
directed
towards
the
development
of
smart,
stimuli-responsive
that
are
capable
releasing
cargos
response
specific
stimuli.
These
intelligent-responsive
can
be
further
surface-functionalized
so
as
achieve
active
tumor
targeting
a
sequential
manner,
which
simply
modulated
by
By
applying
this
methodological
approach,
these
different
target-specific
organs,
tissues,
or
cells
exhibit
on-demand
controlled
drug
release
may
enhance
therapeutic
effectiveness
reduce
systemic
toxicity.
Light,
external
stimulus,
is
one
most
promising
triggers
for
use
nanomedicine
stimulate
from
nanocarriers.
Light-triggered
achieved
through
light
irradiation
at
wavelengths,
either
UV,
visible,
even
NIR
region,
depending
on
photophysical
photo-responsive
molecule
embedded
nanocarrier
system,
structural
characteristics,
material
composition
system.
review,
we
highlighted
emerging
functional
nanocarriers,
with
emphasis
light-responsive
liposomes
dual-targeted
liposomes.
Moreover,
provided
up-to-date
photo-triggered
strategies
mechanisms
light-triggered
NIR-responsive
Lastly,
addressed
current
challenges,
advances,
future
perspectives
deployment
targeted
delivery
therapy.
Abstract
Metal‐organic
frameworks
(MOFs)
are
a
new
variety
of
solid
crystalline
porous
functional
materials.
As
an
extension
inorganic
materials,
it
has
made
important
progress
in
preparation
and
application.
MOFs
widely
used
various
fields
such
as
gas
adsorption
storage,
drug
delivery,
sensing,
biological
imaging
due
to
their
high
specific
surface
area,
porosity,
adjustable
pore
size,
abundant
active
sites,
modification
by
introducing
groups.
In
this
paper,
the
types
classified,
synthesis
methods
mechanisms
materials
summarized.
Finally,
application
prospects
challenges
metal‐organic
framework
biomedical
field
discussed,
hoping
promote
multidisciplinary
fields.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 1076 - 1076
Опубликована: Авг. 16, 2024
Preclinical
and
clinical
studies
have
demonstrated
that
precision
therapy
has
a
broad
variety
of
treatment
applications,
making
it
an
interesting
research
topic
with
exciting
potential
in
numerous
sectors.
However,
major
obstacles,
such
as
inefficient
unsafe
delivery
systems
severe
side
effects,
impeded
the
widespread
use
medicine.
The
purpose
drug
(DDSs)
is
to
regulate
time
place
release
action.
They
aid
enhancing
equilibrium
between
medicinal
efficacy
on
target
hazardous
effects
off
target.
One
promising
approach
biomaterial-assisted
biotherapy,
which
takes
advantage
biomaterials’
special
capabilities,
high
biocompatibility
bioactive
characteristics.
When
administered
via
different
routes,
molecules
deal
biological
barriers;
DDSs
help
them
overcome
these
hurdles.
With
their
adaptable
features
ample
packing
capacity,
biomaterial-based
allow
for
targeted,
localised,
prolonged
medications.
Additionally,
they
are
being
investigated
more
controlling
interface
host
tissue
implanted
biomedical
materials.
This
review
discusses
innovative
nanoparticle
designs
non-personalised
applications
improve
therapies.
We
prioritised
design
trends
address
heterogeneous
barriers,
because
we
believe
intelligent
can
patient
outcomes
by
enabling
improving
general
efficacy.
additionally
reviewed
most
recent
literature
biomaterials
used
biotherapy
vaccine
development,
covering
delivery,
stem
cell
therapy,
gene
other
similar
fields;
also
addressed
difficulties
future
biotherapies.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
