Ruthenium-Based Photoactivated Chemotherapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(43), С. 23397 - 23415

Опубликована: Окт. 17, 2023

Ruthenium(II) polypyridyl complexes form a vast family of molecules characterized by their finely tuned photochemical and photophysical properties. Their ability to undergo excited-state deactivation via photosubstitution reactions makes them quite unique in inorganic photochemistry. As consequence, they have been used, general, for building dynamic molecular systems responsive light but, more particularly, the field oncology, as prodrugs new cancer treatment modality called photoactivated chemotherapy (PACT). Indeed, coordination bond be selectively broken under visible irradiation offers fascinating perspectives oncology: it is possible make poorly toxic agents dark that become activated toward cell killing simple compound inside tumor. In this Perspective, we review most important concepts behind PACT idea, relationship between ruthenium compounds used those related phototherapeutic approach photodynamic therapy (PDT), discuss questions about real-life applications clinic. We conclude Perspective with challenges an outlook.

Язык: Английский

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Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron–Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer

Advanced Materials, Год журнала: 2024, Номер 36(26)

Опубликована: Март 29, 2024

Abstract Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth tissue penetration and nontoxicity due the unique anatomical location near abdominal surface. However, low electron–hole separation efficiency wide bandgap sonosensitizers limit effectiveness SDT. This study aims develop a TiO 2 ‐Ru‐PEG Schottky heterojunction sonosensitizer with narrow for SDT in BC. Density functional theory (DFT) calculations experiments collectively demonstrate that reduced characteristic crystalline‐amorphous interface formed by deposition ruthenium (Ru) within shell layer . Thanks enhancement oxygen adsorption efficient pairs, promotes generation reactive species (ROS) under ultrasound (US) irradiation, resulting cell cycle arrest apoptosis tumor cells. The vivo results prove boosted subcutaneous orthotopic models while exhibiting good safety. adopts complex optimizing sonosensitizers, contributing progress improvement strategies presenting paradigm BC therapy.

Язык: Английский

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Год журнала: 2024, Номер 15(31), С. 12234 - 12257

Опубликована: Янв. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Язык: Английский

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DNA-Targeting Bioactive Photosensitizer for Chemo-Photodynamic Therapy of Malignant Tumor

ACS Materials Letters, Год журнала: 2024, Номер 6(3), С. 969 - 975

Опубликована: Фев. 15, 2024

The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.

Язык: Английский

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Photoresponsive Ru Metalloprodrug Assemblies: Red‐Light‐Controlled Self‐Delivery Systems for Enhanced Anticancer Phototherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(25)

Опубликована: Янв. 22, 2024

Abstract Small‐molecule ruthenium (Ru) complexes exhibit limitations in terms of nonspecific delivery, rapid metabolism, and low tumor accumulation. Their delivery can be improved through physical encapsulation into nanocarriers via hydrophobic forces, metallophilic interactions, or π–π stacking interactions. However, delivering Ru for efficient therapy is substantially hindered by potential leakage drugs, drug‐loading capacity, batch‐to‐batch variations. Moreover, current metalloprodrug‐based self‐delivery systems necessitate supramolecular which are unsuitable because their octahedral structures. Herein, two self‐assembled molecular Ru‐3XOEG Ru‐PEG, reported. involves a three‐arm dendritic oligo(ethylene glycol) (OEG), while Ru‐PEG linear poly(ethylene (PEG) chain. Furthermore, these drugs contain an anticancer moiety planar pyrene to render forces self‐assembles large compound micelles. vesicles. These Ru‐containing self‐delivered well‐defined structures, high loading contents, long circulation blood without external nanocarriers. Red light irradiation induces the release Ru‐H 2 O agents generation 1 inhibit growth. The presented design opens avenues concept metalloprodrugs.

Язык: Английский

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Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(13), С. 11125 - 11137

Опубликована: Июнь 21, 2024

The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. showed impressive light-triggered under normoxia hypoxia compared clinically used photosensitizer Chlorin e6. mechanistic studies that induced redox imbalance perturbed energy metabolism biosynthesis in A549 cancer cells. Overall, this work provides a new strategy developing metal-based complexes phototherapy NIR light.

Язык: Английский

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Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер unknown, С. 114634 - 114634

Опубликована: Янв. 1, 2025

Язык: Английский

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Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Abstract Recent advances in developing photonic technologies using various materials offer enhanced biosensing, therapeutic intervention, and non‐invasive imaging healthcare. Here, this article summarizes significant technological advancements materials, devices, bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, on‐skin health monitoring. The details of required necessary properties, device configurations are described next‐generation followed by an explanation the working principles light‐based therapeutics diagnostics. Next, paper shares recent examples integrated systems focusing on translation immediate clinical studies. In addition, limitations existing devices future directions smart discussed. Collectively, review focus trends new nanomaterials, light delivery methods, system designs, mechanical structures, material functionalization, to advance digital

Язык: Английский

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Reversible Crosslinking of Commodity Polymers via Photocontrolled Metal–Ligand Coordination for High‐Performance and Recyclable Thermoset Plastics

Advanced Materials, Год журнала: 2023, Номер 35(41)

Опубликована: Июль 4, 2023

Thermoset plastics, highly desired for their stability, durability, and chemical resistance, are currently consumed in over 60 million tons annually across the globe, but they difficult to recycle due crosslinked structures. The development of recyclable thermoset plastics is an important challenging task. In this work, prepared by crosslinking a commodity polymer, polyacrylonitrile (PAN), with small percentage Ru complex via nitrile-Ru coordination. PAN obtained from industry synthesized one step, which enables production efficient way. addition, exhibit impressive mechanical performance, boasting Young's modulus 6.3 GPa tensile strength 109.8 MPa. Moreover, can be de-crosslinked when exposed both light solvent then re-crosslinked upon heating. This reversible mechanism recycling thermosets mixture plastic waste. preparation other polymers such as poly(styrene-coacrylonitrile) (SAN) resins polymer composites through also demonstrated. study shows that metal-ligand coordination new strategy designing using polymers.

Язык: Английский

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A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Язык: Английский

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