Nanozyme for tumor therapy: Surface modification matters

Exploration, Год журнала: 2021, Номер 1(1), С. 75 - 89

Опубликована: Авг. 1, 2021

As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease production modification, paving way for biomedical applications. Among them, tumor catalytic therapy mediated by reactive oxygen species (ROS) has made great progress mainly from peroxidase-like activity nanozymes. Fe

Язык: Английский

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Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 30, 2022

Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated (TAMs) in the tumor microenvironment (TME) are composed of heterogeneous subpopulations, which include anti-tumor M2 pro-tumor phenotypes. TAMs predominantly play a M2-like tumor-promoting role TME regulate various malignant effects, such as angiogenesis, immune suppression, metastasis; hence, have emerged hot topic research cancer therapy. This review focuses on three main aspects TAMs. First, we summarize macrophage polarization along with effects TME. Second, recent advances challenges treatment checkpoint blockade CAR-T cell therapy emphasized. Finally, factors, signaling pathways, associated TAM potential strategies for targeting repolarization to pro-inflammatory phenotype discussed.

Язык: Английский

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Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy

Nano Letters, Год журнала: 2021, Номер 21(10), С. 4231 - 4240

Опубликована: Май 17, 2021

The tumor immunosuppressive microenvironment greatly limits the efficacy of immunotherapy. Tumor-associated macrophages (TAMs) are most abundant cells in microenvironment, which can inhibit after converting it to an M1-like phenotype. In addition, immunogenic cell death (ICD) increase amount T lymphocytes tumors, activating antineoplastic immunity. Herein, tumor-associated macrophage polarization therapy supplemented with PLGA-DOX (PDOX)-induced ICD is developed for cancer treatment. nanoparticles/bacteria complex (Ec-PR848) fabricated targeting and TAM polarization, PLGA-R848 (PR848) attached surface Escherichia coli (E. coli) MG1655 via electrostatic absorption. toll-like receptor 7/8 (TLR7/8) agonist resiquimod (R848) E. polarize M2 M1 macrophages, while PDOX-induced also impair immunosuppression microenvironment. This strategy shows that combined induced by low-dose chemotherapeutic drugs commendably enhance

Язык: Английский

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Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)

Опубликована: Фев. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Язык: Английский

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

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Cell membrane coated-nanoparticles for cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(8), С. 3233 - 3254

Опубликована: Фев. 28, 2022

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of had positive effects on clinical treatment. However, is still restricted heterogeneity, immune cell disability, tumor immunosuppressive microenvironment systemic toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including "self" markers, cross-talking biological targeting, homing to specific regions. These enable them possess preferred characteristics, better compatibility, weak immunogenicity, escaping, a prolonged circulation, targeting. Therefore, they are applied precisely deliver drugs promote effect immunotherapy. In review, we summarize latest researches biomimetic CMCNs for immunotherapy, outline existing therapies, explore unique functions molecular mechanisms various nanoparticles, analyze challenges which face in translation.

Язык: Английский

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Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis

Journal of Controlled Release, Год журнала: 2022, Номер 352, С. 211 - 241

Опубликована: Окт. 21, 2022

Язык: Английский

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Harnessing anti‐tumor and tumor‐tropism functions of macrophages via nanotechnology for tumor immunotherapy

Exploration, Год журнала: 2022, Номер 2(3)

Опубликована: Фев. 25, 2022

Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in immunotherapy. As a class of professional phagocytes and antigen-presenting cells innate immune system, can not only directly engulf clear cells, but also play roles presenting tumor-specific antigen to initiate adaptive immunity. However, tumor-associated (TAMs) usually display tumor-supportive M2 phenotype rather than anti-tumor M1 phenotype. They support escape immunological surveillance, aggravate progression, impede T cell Although many TAMs-modulating agents have shown success therapy multiple tumors, they face enormous challenges including poor accumulation off-target side effects. An alternative solution is use advanced nanostructures, which deliver augment therapeutic efficacy, serve as modulators TAMs. Another important strategy exploitation macrophage-derived components tumor-targeting delivery vehicles. Herein, we summarize recent advances targeting engineering for immunotherapy, (1) direct indirect effects on augmentation immunotherapy (2) strategies macrophage-based drug carriers. The existing perspectives immunotherapies are highlighted.

Язык: Английский

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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Дек. 27, 2022

Abstract Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is still a challenging task against the complex intercellular environment. Once synthetic enter body, they phagocytosed by immune cells system. Recently, cell membrane camouflage strategy has emerged as novel therapeutic tactic to overcome these issues utilizing fundamental properties of natural cells. Macrophage, type system cells, plays critical roles in various diseases, including cancer, atherosclerosis, rheumatoid arthritis, infection and inflammation, due recognition engulfment function removing substances pathogens. Macrophage membranes inherit protein profiles biointerfacing source Therefore, macrophage cloaking can protect from phagocytosis Meanwhile, make use correspondence accurately recognize antigens target inflamed tissue or tumor sites. In this review, we have summarized advances fabrication, characterization homing capacity cancers, cardiovascular central nervous microbial infections. Although membrane-camouflaged currently fetal stage development, there huge potential challenge explore conversion mode clinic.

Язык: Английский

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Hybrid‐Membrane‐Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor‐Associated Macrophages Polarization and Hypoxia Relief

Advanced Materials, Год журнала: 2022, Номер 34(14)

Опубликована: Фев. 1, 2022

Both tumor-associated macrophages (TAMs) and hypoxia condition severely restrict the antitumor potency during cancer immunotherapy. It is essential to overcome two issues for improving therapeutic efficacy. In this study, a hollow mesoporous Prussian blue (HMPB) nanosystem with mannose decoration hydroxychloroquine (HCQ) adsorption built, form Man-HMPB/HCQ. can facilitate cellular internalization via mannose-receptor mediated endocytosis induce TAM polarization iron ion/HCQ release HMPB degradation. The hybrid macrophage thylakoid (TK) membrane camouflaged on Man-HMPB/HCQ surface, denoted as TK-M@Man-HMPB/HCQ, reduce in vivo reticuloendothelial system uptake, enhance tumor accumulation, mitigate hypoxia. results indicate that TK-M@Man-HMPB/HCQ notably inhibits growth, induces polarization, facilitates cytotoxic T lymphocytes infiltration, alleviates microenvironment. rational design may provide new pathway modulate microenvironment promoting immunotherapy effects.

Язык: Английский

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