Layered double hydroxide-based nanomaterials for biomedical applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(14), С. 6126 - 6176

Опубликована: Янв. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Язык: Английский

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Recent developments in 2D transition metal dichalcogenides: phase transition and applications of the (quasi-)metallic phases

Chemical Society Reviews, Год журнала: 2021, Номер 50(18), С. 10087 - 10115

Опубликована: Янв. 1, 2021

This review outlines the semiconducting-(quasi)metallic phase transition of 2D-TMDs and discusses current developments in application this unique phase. Challenges future developmental trends TMD-based systems are also highlighted.

Язык: Английский

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A Borondifluoride‐Complex‐Based Photothermal Agent with an 80 % Photothermal Conversion Efficiency for Photothermal Therapy in the NIR‐II Window

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(41), С. 22376 - 22384

Опубликована: Июль 21, 2021

Abstract Small organic photothermal agents (SOPTAs) that absorb in the second near‐infrared (NIR‐II, 1000–1700 nm) window are highly desirable therapy for their good biocompatibility and deeper tissue penetration. However, design of NIR‐II absorbing SOPTAs remains a great challenge. Herein, we report molecular engineering BF 2 complex via strengthening donor‐acceptor conjugation increasing intramolecular motions is an efficient strategy to achieve with high performance. Based on this strategy, complex, BAF4, was designed synthesized. BAF4 exhibits intense absorption maximum at 1000 nm negligible fluorescence. Notably, nanoparticles conversion efficiency value 80 % under 1064 laser irradiation (0.75 W cm −2 ). In vitro vivo studies reveal potential photoacoustic imaging‐guided window.

Язык: Английский

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MoS2-based nanocomposites for cancer diagnosis and therapy

Bioactive Materials, Год журнала: 2021, Номер 6(11), С. 4209 - 4242

Опубликована: Апрель 27, 2021

Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used biomedical research. Especially, MoS2-nanomaterials attracted more attention cancer diagnosis treatment recently because their unique physical chemical properties. MoS2 can adsorb various biomolecules drug molecules via covalent or non-covalent interactions it easy to modify possess high specific surface area, improving its tumor targeting colloidal stability, well accuracy sensitivity detecting biomarkers. At same time, near-infrared (NIR) window, has excellent optical absorption prominent photothermal conversion efficiency, which achieve NIR-based phototherapy NIR-responsive controlled drug-release. Significantly, modified MoS2-nanocomposite specifically respond microenvironment, leading accumulation site increased, reducing side effects on non-cancerous tissues, improved therapeutic effect. In this review, we introduced latest developments MoS2-nanocomposites therapy, mainly focusing biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, combination therapy. Furthermore, also discuss current challenges prospects treatment.

Язык: Английский

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Synthesis of atomically thin sheets by the intercalation-based exfoliation of layered materials

Nature Synthesis, Год журнала: 2023, Номер 2(2), С. 101 - 118

Опубликована: Фев. 13, 2023

Язык: Английский

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Emerging Trends in Nanomaterials for Antibacterial Applications

International Journal of Nanomedicine, Год журнала: 2021, Номер Volume 16, С. 5831 - 5867

Опубликована: Авг. 1, 2021

Abstract: Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, metal ion release photodynamic photothermal effects nanomaterials were demonstrated to have substantial efficiency in eliminating resistance bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, optical features been utilized control release, generate reactive oxygen species, produce heat for antibacterial applications. The superior present an opportunity explore enhance their activities leading clinical In this review, we comprehensively list three different mechanisms therapy, therapy based on nanomaterials. These divided into respective subgroups accordance recent achievements, showcasing prospective challenges opportunities clinical, environmental, fields. Keywords: nanomaterials, ions, photodynamic, photothermal, mechanism, species Graphical

Язык: Английский

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Near-infrared inorganic nanomaterial-based nanosystems for photothermal therapy

Nanoscale, Год журнала: 2021, Номер 13(19), С. 8751 - 8772

Опубликована: Янв. 1, 2021

We summarize the recent advances in near-infrared inorganic nanomaterial-based nanosystems for photothermal therapy this review.

Язык: Английский

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Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy

Small, Год журнала: 2021, Номер 17(12)

Опубликована: Фев. 16, 2021

Abstract Layered metal oxides including MoO 3 and WO have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, easy preparation. However, they normally exhibit weak or negligible near‐infrared (NIR) absorption thus are inefficient photo‐induced biomedical applications. Herein, the structural engineering of layered nanostructures is first reported activate NIR‐II efficient photothermal cancer therapy in window. White‐colored micrometre‐long nanobelts transformed into blue‐colored short, thin, defective, interlayer gap‐expanded 3− x with a strong via simple lithium treatment. The blue large extinction coefficient 18.2 L g −1 cm high conversion efficiency 46.9% at 1064 nm. After surface modification, can be used as robust nanoagent photoacoustic imaging‐guided achieve cell ablation tumor eradication under irradiation by nm laser. Importantly, biodegradable rapidly degraded excreted from body. study highlights that powerful strategy tune properties boost performances given

Язык: Английский

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Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(22), С. 4459 - 4474

Опубликована: Янв. 1, 2021

In the presented perspective, synthetic method, characterization, and research progress in tumor therapy based on CMMs have been summarized. Also prospects challenges of utilizing for discussed.

Язык: Английский

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Recent Progress on NIR-II Photothermal Therapy

Frontiers in Chemistry, Год журнала: 2021, Номер 9

Опубликована: Июль 29, 2021

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials near-infrared region (NIR-I, 750-900 nm) attracts extensive attention recent years because good biological penetration NIR light. However, depth still not enough for solid tumors due to high tissue scattering. light second (NIR-II, 1000-1700 allows deeper penetration, higher upper limit radiation and greater tolerance than that NIR-I, it shows application potential conversion. This review summarizes properties Au nanomaterials, two-dimensional materials, metal oxide sulfides polymers NIR-II their prospects It will arouse interest scientists as well nanomedicine.

Язык: Английский

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