A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Год журнала: 2022, Номер 35(5)

Опубликована: Ноя. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Язык: Английский

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Microenvironment-Responsive Metal-Phenolic Nanozyme Release Platform with Antibacterial, ROS Scavenging, and Osteogenesis for Periodontitis

ACS Nano, Год журнала: 2023, Номер 17(19), С. 18732 - 18746

Опубликована: Сен. 28, 2023

Periodontitis is a chronic inflammatory disease deriving from dental plaque, characterized by the excessive accumulation of reactive oxygen species (ROS), matrix metalloproteinase (MMP) and other substances, resulting in destruction periodontal tissues. At present, main therapeutic modalities, such as local mechanical debridement antibiotic delivery, are not only difficult to solve intractable bacterial biofilm effectively but also tricky ameliorate response well regenerate impaired Herein, we have proposed TM/BHT/CuTA hydrogel system formed self-assembly copper-based nanozyme (copper tannic acid coordination nanosheets, CuTA NSs) triglycerol monostearate/2,6-di-tert-butyl-4-methylphenol (TM/BHT) hydrogel. The negatively charged can retain at inflammation sites with positive charge through electrostatic adsorption hydrolyze increasing MMP periodontitis, realizing on-demand release nanozyme. released has antibacterial antiplaque properties. Meanwhile, metal-phenolic nanozyme, it scavenge multiple ROS simulating cascade process superoxide dismutase (SOD) catalase (CAT). Further, modulate macrophage polarization M1 phenotype M2 Nrf2/NF-κB pathway, which reduces pro-inflammatory cytokines, increases anti-inflammatory promotes expression osteogenetic genes successively, thus relieving accelerating tissue regeneration periodontitis. Altogether, this multifunctional platform (TM/BHT/CuTA) provides desirable strategy for treatment

Язык: Английский

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Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Март 11, 2023

Abstract The frequent outbreak of global infectious diseases has prompted the development rapid and effective diagnostic tools for early screening potential patients in point-of-care testing scenarios. With advances mobile computing power microfluidic technology, smartphone-based health platform drawn significant attention from researchers developing devices that integrate optical detection with artificial intelligence analysis. In this article, we summarize recent progress these platforms, including aspects chips, imaging modalities, supporting components, software algorithms. We document application platforms terms objects, molecules, viruses, cells, parasites. Finally, discuss prospects future platforms.

Язык: Английский

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Recent advances in Ti-based MOFs in biomedical applications

Dalton Transactions, Год журнала: 2022, Номер 51(39), С. 14817 - 14832

Опубликована: Янв. 1, 2022

This study reviews the development of titanium-based MOFs in therapeutic areas antibacterial therapy, tumor anti-inflammatory and bone injury therapy.

Язык: Английский

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Coupling Probiotics with 2D CoCuMo‐LDH Nanosheets as a Tumor‐Microenvironment‐Responsive Platform for Precise NIR‐II Photodynamic Therapy

Advanced Materials, Год журнала: 2023, Номер 35(23)

Опубликована: Март 13, 2023

Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as TME-responsive platform NIR-II The CoCuMo-LDH loaded on LA can be transformed from crystalline into amorphous through etching by LA-metabolite-enabled low pH and overexpressed glutathione. TME-induced in situ amorphization of boost its photodynamic activity singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation relative 1 quantum yield 1.06, which highest among previously NIR-excited PSs. In vitro vivo assays prove that LA&LDH effectively achieve complete cell apoptosis eradication irradiation. This study proves used highly efficient

Язык: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Фев. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Язык: Английский

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Recent Advances of Silver-Based Coordination Polymers on Antibacterial Applications

Molecules, Год журнала: 2022, Номер 27(21), С. 7166 - 7166

Опубликована: Окт. 23, 2022

With the continuous evolution of bacteria and constant use traditional antibiotics, emergence drug-resistant super viruses has attracted worldwide attention. Antimicrobial therapy become most popular important research field at present. Coordination Polymer (CP) and/or metal-organic framework (MOF) platforms have advantages a high biocompatibility, biodegradability, non-toxicity, great antibacterial potential been widely used in treatment. This paper reviewed mechanism effect three typical MOFs (pure Ag-MOFs, hybrid Ag-containing-polymer @MOFs) silver-based coordination polymers. At same time, existing shortcomings future views are briefly discussed. The study on efficacy Ag-MOFs can provide better basis for its clinical application and, meanwhile, open up novel strategy preparation more advanced Ag-contained materials with characteristics.

Язык: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Год журнала: 2023, Номер 35(17)

Опубликована: Фев. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Язык: Английский

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Plant exosome nanovesicles (PENs): green delivery platforms

Materials Horizons, Год журнала: 2023, Номер 10(10), С. 3879 - 3894

Опубликована: Янв. 1, 2023

Structure of plant-derived vesicles and their bioactive applications. Created with BioRender.com

Язык: Английский

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Materials Chemistry Frontiers, Год журнала: 2023, Номер 7(8), С. 1684 - 1693

Опубликована: Янв. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Язык: Английский

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