Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Advanced Science, Год журнала: 2022, Номер 10(2)

Опубликована: Ноя. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Язык: Английский

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pH-Responsive Polymer Nanomaterials for Tumor Therapy

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Март 22, 2022

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals microenvironment, various stimuli-responsive delivery systems can be constructed sites. Among these, pH is frequently utilized, owing being lower than that blood and healthy tissues. pH-responsive polymer carriers improve efficiency in vivo , allow delivery, reduce adverse reactions, enabling multifunctional personalized treatment. polymers have gained increasing interest due their advantageous properties potential applicability therapy. In this review, recent advances in, common applications of, nanomaterials therapy are summarized, with a focus on different types polymers. Moreover, future field prospected.

Язык: Английский

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Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 220, С. 1277 - 1286

Опубликована: Авг. 27, 2022

In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 12.0 to obtain an efficient nanocomposite for antibacterial anti-cancer activities. The hydrogels were evaluated detailed characterization confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative gram-positive bacteria, which further investigated in-silico molecular docking analyses also examined reactive oxygen species production photocatalysis free radical-scavenging assay. After this, Doxorubicin (DOX), model anticancer drug, successfully loaded into nanocomposites (∼79 %) electrostatic interaction pH-triggered based release, over 53.7 % in 24 h. Finally, vitro cytotoxicity-based analysis antitumor efficacy hydrogels. These findings revealed that might be prospective carriers controlled drug delivery.

Язык: Английский

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An Update on Graphene Oxide: Applications and Toxicity

ACS Omega, Год журнала: 2022, Номер 7(40), С. 35387 - 35445

Опубликована: Сен. 28, 2022

Graphene oxide (GO) has attracted much attention in the past few years because of its interesting and promising electrical, thermal, mechanical, structural properties. These properties can be altered, as GO readily functionalized. Brodie synthesized 1859 by reacting graphite with KClO3 presence fuming HNO3; reaction took 3–4 days to complete at 333 K. Since then, various schemes have been developed reduce time, increase yield, minimize release toxic byproducts (NO2 N2O4). The modified Hummers method widely accepted produce bulk. Due versatile characteristics, a wide range applications different fields like tissue engineering, photocatalysis, catalysis, biomedical applications. Its porous structure is considered appropriate for organ regeneration. Various branches engineering are being extensively explored, such bone, neural, dentistry, cartilage, skin engineering. band gap easily tuned, therefore it photocatalytic well: degradation organic contaminants, hydrogen generation, CO2 reduction, etc. could potential nanocarrier drug delivery systems, gene delivery, biological sensing, antibacterial nanocomposites due large surface area high density, highly functionalized oxygen-containing functional groups. or composites found species also discussed this review. It observed that superoxide dismutase (SOD) reactive oxygen (ROS) levels gradually over period after introduced systems. Hence, specific concentrations earthworms, Chironomus riparius, Zebrafish,

Язык: Английский

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A comprehensive review on the ultrasound-enhanced leaching recovery of valuable metals: Applications, mechanisms and prospects

Ultrasonics Sonochemistry, Год журнала: 2023, Номер 98, С. 106525 - 106525

Опубликована: Июль 13, 2023

In recent two decades, ultrasound has been broadly applied to the hydrometallurgical leaching process recover valuable metals within raw materials, aiming solve shortcomings of conventional process, including relatively low recovery, long duration, high reagent usage, energy consumption and so on. The present work focuses on a comprehensive overview ultrasound-enhanced various metals, such as common nonferrous ferrous rare earth elements, precious from metal ores secondary resources. Moreover, enhanced mechanisms by are discussed in detail summarized based improvement kinetics, enhancement mass transfer diffusion lixiviants, promotion oxidative conversion insoluble soluble states. Lastly, challenges outlooks future research recovery for with assistance irradiation proposed.

Язык: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Год журнала: 2023, Номер 1(1)

Опубликована: Фев. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Язык: Английский

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State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT

Chemical Engineering Journal, Год журнала: 2022, Номер 449, С. 137889 - 137889

Опубликована: Июль 4, 2022

Язык: Английский

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Fundamentals, advances and perspectives of piezocatalysis: A marriage of solid-state physics and catalytic chemistry

Progress in Materials Science, Год журнала: 2023, Номер 138, С. 101161 - 101161

Опубликована: Июль 16, 2023

Piezocatalysis, an evolving catalytic technology built on the piezoelectric properties of catalysts, breaks down barrier between mechanical energy and chemical energy. The potential difference that arises from deformation a material is commonly termed 'piezopotential'. Piezopotential has been demonstrated to facilitate manipulation band structure and/or charge carrier separation. Despite significant efforts design materials understand mechanism piezoelectrically enhanced chemistry through semiconductor physics, there remains opportunity review relationships performance piezo/ferroelectric properties. Herein, we provide comprehensive summary mechanisms correlated physical in field piezocatalysis. A fundamental understanding structural based solid-state physics can be used shed light future development In addition, types materials, strategies for catalysis efficiency enhancement, up-to-date applications environment remediation, renewable conversion, biomedicine biotechnology are discussed. Finally, perspectives designing developing highly active piezocatalysts using guidelines physicochemical proposed.

Язык: Английский

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Piezocatalytic 2D WS₂ Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy

Advanced Materials, Год журнала: 2023, Номер 35(18)

Опубликована: Фев. 13, 2023

Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as effective platform for cancer therapy. In this study, 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) ultrasound (US)-triggered, mitochondria-targeted piezodynamic addition, a glycolysis inhibitor (FX11) inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol) (PEG)-conjugated nanosheet (TPEG-WS2 ) to potentiate its therapeutic efficacy. Upon US irradiation, the sono-excited electrons holes generated in efficiently separated polarization, which subsequently promotes production of ROS. FX11-loaded TPEG-WS2 (FX11@TPEG-WS2 selectively accumulates mitochondria human breast cells. FX11@TPEG-WS2 effectively inhibits adenosine triphosphate . Thus, exhibits outstanding anticancer effects irradiation. An vivo study using tumor-xenograft mice demonstrates accumulated tumors. Its tumor accumulation visualized computed tomography Notably, irradiation remarkably suppresses growth without systemic toxicity. This combination therapy metabolism-targeted chemotherapy novel strategy selective treatment

Язык: Английский

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Graphene-Based Electrochemical Biosensors for Breast Cancer Detection

Biosensors, Год журнала: 2023, Номер 13(1), С. 80 - 80

Опубликована: Янв. 3, 2023

Breast cancer (BC) is the most common in women, which also second public worldwide. When detected early, BC can be treated more easily and prevented from spreading beyond breast. In recent years, various biosensor strategies have been studied, including optical, electrical, electrochemical, mechanical biosensors. particular, high sensitivity short detection time of electrochemical biosensors make them suitable for recognition biomarkers. Moreover, increased by incorporating nanomaterials. this respect, outstanding electrical performances graphene led to an increasingly intense study graphene-based materials Hence, present review examines latest advances biosensing. For each biosensor, limit (LOD), linear range (LR), diagnosis technique are analyzed. This followed a discussion prospects current challenges, along with potential enhancing performance

Язык: Английский

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