Science Advances, Год журнала: 2024, Номер 10(33)
Опубликована: Авг. 14, 2024
Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a biomimetic double wound mask (BDM) rapid autophasing hierarchical programming for scarless healing. The BDMs comprise hydrophobic poly (lactide-
Язык: Английский
Military Medical Research, Год журнала: 2023, Номер 10(1)
Опубликована: Авг. 22, 2023
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.
Язык: Английский
Процитировано
157
Nano Research, Год журнала: 2023, Номер 16(2), С. 3475 - 3515
Опубликована: Янв. 3, 2023
Язык: Английский
Процитировано
154
Bioactive Materials, Год журнала: 2023, Номер 26, С. 88 - 101
Опубликована: Фев. 24, 2023
Skin wounds are a major medical challenge that threaten human health. Functional hydrogel dressings demonstrate great potential to promote wound healing. In this study, magnesium (Mg) and zinc (Zn) introduced into methacrylate gelatin (GelMA) via low-temperature magnetic stirring photocuring, their effects on skin the underlying mechanisms investigated. Degradation testing confirmed GelMA/Mg/Zn released ions (Mg2+) (Zn2+) in sustained manner. The Mg2+ Zn2+ not only enhanced migration of fibroblasts (HSFs) immortalized keratinocytes (HaCats), but also promoted transformation HSFs myofibroblasts accelerated production remodeling extracellular matrix. Moreover, healing full-thickness defects rats collagen deposition, angiogenesis re-epithelialization. We identified through which healing: entry increased concentration HSFs, effectively induced differentiate by activating STAT3 signaling pathway. synergistic effect conclusion, our study provides promising strategy for regeneration.
Язык: Английский
Процитировано
110
BMEMat, Год журнала: 2023, Номер 1(2)
Опубликована: Апрель 15, 2023
Abstract Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is complicated and dynamic physiological process with distinct molecular cellular levels at each phase. Despite numerous strategies advanced wound dressings being developed, successful management through smart dressing materials that can adapt changing microenvironments address needs different stages remains big challenge. Over last decade, hydrogel‐based have emerged as one most potent biomaterials for treatment favorable biological characteristics high potential active intervention during wound‐curing process. In current contribution, we present recent progress in hydrogel regulate release therapeutics response external stimuli (such light) well endogenous changes environments (e.g., temperature, pH, glucose, reactive oxygen species) facilitate healing. We also introduce cutting‐edge technologies intelligent “sense‐and‐treat” combination built‐in sensors sensing molecules responsive hydrogels, which enable real‐time monitoring conditions prompt on‐demand therapy.
Язык: Английский
Процитировано
106
Materials Today Bio, Год журнала: 2022, Номер 16, С. 100429 - 100429
Опубликована: Сен. 15, 2022
Язык: Английский
Процитировано
96
Advanced Functional Materials, Год журнала: 2023, Номер 33(21)
Опубликована: Март 14, 2023
Abstract The common techniques to improve hydrogel's mechanical properties include increasing crosslinking density and forming crosslinked double‐network hydrogel, which may cause some hydrogels lose their smart functionalities. Inspired by entanglement‐induced strengthening, a simple approach introducing hydroxypropyl cellulose (HPC) fibers entangled with different hydrogel matrix systems are reported. Different from the conventional methods hinder movement of polymer network, through entanglement HPC fibers, composite shows both improved Young's modulus toughness more importantly functionalities including response speed, anti‐drying, anti‐freezing capabilities cycle stability. This strategy provides new design rule fabricate durable strengthened can be used in windows, sensors, soft robots.
Язык: Английский
Процитировано
81
Gels, Год журнала: 2024, Номер 10(1), С. 43 - 43
Опубликована: Янв. 5, 2024
The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.
Язык: Английский
Процитировано
81
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(19)
Опубликована: Март 20, 2023
Chronic wound healing is a major challenge in biomedicine. Conventional therapies are usually associated with poor drug permeability, low bioavailability, risk of antimicrobial resistance, and require frequent administration. Therefore, novel formulation reduced antibiotic dosage, improved delivery efficiency, application frequency remarkable interest for chronic healing. Herein, multifunctional microneedle (MN) patch presented to achieve rapid via efficient chemo-photodynamic antibacterial effect sustained release growth factors at the bed. When MN pierces skin, tips carrying both dosage antibiotics bioactive small molecule-encapsulated metal-organic frameworks (MOFs) rapidly dissolve subsequently deliver payloads wound. Upon light irradiation, MOF-based nanoparticles robustly convert O2 into 1 , which acts synergistically chemotherapy remove pathogenic bacteria from wound, exhibiting excellent performance tenfold reduction required amount. The can continuous tissue, promoting formation epithelial tissue neovascularization, thereby further accelerating Collectively, designed patches offer simple, safe, effective alternative management.
Язык: Английский
Процитировано
62
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125949 - 125949
Опубликована: Июль 24, 2023
Язык: Английский
Процитировано
50
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(22)
Опубликована: Май 17, 2023
Post-injury infection and wound healing are recurrent daily life problems. Therefore, the necessity of developing a biomaterial with antibacterial wound-healing properties is paramount. Based on special porous structure hydrogel, this work modifies recombinant collagen quaternary ammonium chitosan fused them silver nanoparticles (Ag@mental-organic framework (Ag@MOF)) properties, asiaticoside-loaded liposomes (Lip@AS) anti-inflammatory/vascularization effects to form rColMA/QCSG/LIP@AS/Ag@MOF (RQLAg) hydrogel. The prepared hydrogel possesses good sustainable release capabilities Ag
Язык: Английский
Процитировано
45