Abstract
Wound
healing
is
a
dynamic
process
involving
the
timely
transition
of
organized
phases.
However,
infected
wounds
often
experience
prolonged
inflammation
due
to
microbial
overload.
Thus,
addressing
viable
treatment
needs
across
different
stages
critical
challenge
in
wound
management.
Herein,
novel
core‐shell
microneedle
(CSMN)
patch
designed
for
sequential
delivery
tannic
acid‐magnesium
(TA‐Mg)
complexes
and
extracellular
vesicles
from
Lactobacillus
druckerii
(LDEVs).
Upon
application
sites,
CSMN@TA‐Mg/LDEV
releases
TA‐Mg
first
counteract
pathogenic
overload
reduce
reactive
oxygen
species
(ROS),
aiding
proliferative
phase.
Subsequently,
sustained
release
LDEVs
enhances
activities
keratinocytes
fibroblasts,
promotes
vascularization,
modulates
collagen
deposition.
Notably,
track
composition
demonstrates
that
can
both
inhibit
aggressive
pathogen
increase
diversity
at
sites.
Functional
analysis
further
highlights
potential
facilitating
skin
barrier
restoration.
Moreover,
it
confirmed
accelerate
closure
improve
post‐recovery
quality
murine
wound.
Conclusively,
this
innovative
CSMN
offers
rapid
high‐quality
alternative
emphasizes
significance
homeostasis.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 27, 2024
Abstract
Antibacterial
photodynamic
therapy
(aPDT)
and
antibacterial
sonodynamic
(aSDT)
utilize
sensitizers
(photosensitizers/sonosensitizers)
to
produce
reactive
oxygen
species
(ROS)
for
treatment
under
the
stimulation
of
light/ultrasound,
which
have
characteristics
broad‐spectrum
properties,
low
drug‐resistance,
effective
targeting
infected
tissues.
Nanomaterials
in
aPDT/aSDT
are
primarily
used
as
nano‐sensitizers
or
nano‐carriers
sensitizers.
They
enhance
stability
permeability
sensitizers,
improve
strengthen
photodynamic/sonodynamic
properties
(modification
absorption
efficiency
light/ultrasonic
response
stress
by
modulation
nanoparticle
shape,
size,
structure).
Also,
they
modifiability
(controlling
release
rate
time
sensitizer
needed
optimize
therapeutic
effect),
programmability
multifunctionality
(flexible
application
nanotechnology
designing
with
multiple
functions,
such
drug
delivery,
targeted
therapy,
monitoring),
expand
possibilities
combination
therapies
(the
can
be
loaded
other
agents,
enabling
therapies).
expected
further
promote
development
achieve
improved
effects.
This
review
summarizes
progress
nanomaterials
recent
years
based
on
current
strategies
provide
a
theoretical
reference
aPDT/aSDT.
Advanced Materials,
Год журнала:
2024,
Номер
36(15)
Опубликована: Фев. 2, 2024
Abstract
Hypoxia
and
infection
are
urgent
clinical
problems
in
chronic
diabetic
wounds.
Herein,
living
Chlorella
‐loaded
poly(ionic
liquid)‐based
microneedles
(PILMN‐Chl)
constructed
for
microacupuncture
oxygen
antibacterial
therapy
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)‐infected
The
PILMN‐Chl
can
stably
continuously
produce
more
than
30
h
due
to
the
photosynthesis
of
loaded
self‐supported
.
By
combining
barrier
penetration
capabilities
microneedles,
continuous
sufficient
supply
,
sterilization
activities
PIL,
accelerate
wounds
vivo
by
topical
targeted
hypoxia
relief
deep
parts
Thus,
self‐oxygen
produced
modality
may
provide
a
promising
facile
therapeutic
strategy
treating
chronic,
hypoxic,
infected
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 965 - 992
Опубликована: Янв. 1, 2024
Abstract:
Diabetic
wounds
pose
a
significant
challenge
to
public
health,
primarily
due
insufficient
blood
vessel
supply,
bacterial
infection,
excessive
oxidative
stress,
and
impaired
antioxidant
defenses.
The
aforementioned
condition
not
only
places
physical
burden
on
patients'
prognosis,
but
also
amplifies
the
economic
strain
medical
system
in
treating
diabetic
wounds.
Currently,
effectiveness
of
available
treatments
for
is
limited.
However,
there
hope
potential
metal
nanoparticles
(MNPs)
address
these
issues.
MNPs
exhibit
excellent
anti-inflammatory,
antioxidant,
antibacterial
pro-angiogenic
properties,
making
them
promising
solution
In
addition,
stimulate
expression
proteins
that
promote
wound
healing
serve
as
drug
delivery
systems
small-molecule
drugs.
By
combining
with
other
biomaterials
such
hydrogels
chitosan,
novel
dressings
can
be
developed
revolutionize
treatment
present
article
provides
comprehensive
overview
research
progress
utilization
Building
upon
this
foundation,
we
summarize
underlying
mechanisms
involved
discuss
application
delivery.
Furthermore,
provide
an
extensive
analysis
discussion
clinical
implementation
dressings,
while
highlighting
future
prospects
utilizing
management.
conclusion,
represent
strategy
healing.
Future
directions
include
biological
nanomaterials
synthesize
new
or
physicochemical
properties
Synthetic
contain
play
role
all
stages
healing,
stable
physiological
environment
wound-healing
process.
Keywords:
nanoparticles,
wound,
delivery,
activity
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Май 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
