Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101098 - 101098
Опубликована: Май 22, 2024
Developing
patches
that
effectively
merge
intrinsic
deformation
characteristics
of
cardiac
with
superior
tunable
mechanical
properties
remains
a
crucial
biomedical
pursuit.
Currently
used
traditional
block-shaped
or
mesh
patches,
typically
incorporating
positive
Poisson's
ratio,
often
fall
short
matching
the
tissue
satisfactorily,
thus
diminishing
their
repairing
capability.
By
introducing
auxeticity
into
this
study
is
trying
to
present
beneficial
approach
address
these
shortcomings
patches.
The
featuring
auxetic
effect,
offer
unparalleled
conformity
complex
challenges.
Initially,
scaffolds
demonstrating
effect
were
designed
by
merging
chiral
rotation
and
concave
angle
units,
followed
integrating
composite
hydrogel
through
thermally
triggering,
ensuring
excellent
biocompatibility
closely
mirroring
heart
tissue.
Tensile
tests
revealed
possessed
elasticity
strain
capacity
exceeding
tissue's
physiological
activity.
Notably,
Model
III
showed
an
equivalent
modulus
ratio
toward
tissue,
underscoring
its
outstanding
potential
as
Cyclic
tensile
loading
demonstrated
withstood
continuous
heartbeats,
showcasing
cyclic
recovery
capabilities.
Numerical
simulations
further
elucidated
failure
mechanisms
leading
exploration
influence
on
alternative
design
parameters,
which
enabled
customization
strength
ratio.
Therefore,
research
presents
substantial
for
designing
can
emulate
possess
adjustable
parameters.
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
crosslinks
widely
applied
for
drug
delivery
applications
because
of
their
ability
to
hold
large
amounts
water
and
biological
fluids
control
release
based
on
unique
physicochemical
properties
biocompatibility.
Current
trends
in
the
development
hydrogel
systems
involve
drugs
response
specific
triggers
such
as
pH,
temperature,
or
enzymes
targeted
reduce
potential
systemic
toxicity.
In
addition,
developing
injectable
formulations
that
easily
used
sustain
during
this
extended
time
is
a
growing
interest.
Another
emerging
trend
synthesis
nano
other
functional
substances
improving
loading
efficacy.
Following
these
trends,
advanced
possessing
mechanically
improved
properties,
controlled
rates,
biocompatibility
focus
field.
More
complex
multi-drug
combination
therapies
will
be
developed
advancements.
polymer-based
gaining
increasing
attention
personalized
medicine
tailored
patient,
example,
combinations,
target-specific
delivery,
improvement
disease
treatment
effectiveness,
healthcare
cost
reduction.
Overall,
application
advancing
rapidly,
towards
more
efficient
effective
future.
Bioactive Materials,
Год журнала:
2023,
Номер
30, С. 129 - 141
Опубликована: Июль 28, 2023
In
clinical
applications,
there
is
a
lack
of
wound
dressings
that
combine
efficient
resistance
to
drug-resistant
bacteria
with
good
self-healing
properties.
this
study,
series
adhesive
conductive
antibacterial
hydrogel
based
on
oxidized
sodium
alginate-grafted
dopamine/carboxymethyl
chitosan/Fe3+
(OSD/CMC/Fe
hydrogel)/polydopamine-encapsulated
poly(thiophene-3-acetic
acid)
(OSD/CMC/Fe/PA
hydrogel)
were
prepared
for
the
repair
infected
wound.
The
Schiff
base
and
Fe3+
coordination
bonds
structure
are
dynamic
can
be
repaired
automatically
after
network
disrupted.
Macroscopically,
exhibits
properties,
allowing
dressing
adapt
complex
surfaces.
OSD/CMC/Fe/PA
showed
conductivity
photothermal
properties
under
near-infrared
(NIR)
light
irradiation.
addition,
hydrogels
exhibit
tunable
rheological
suitable
mechanical
antioxidant
tissue
adhesion
hemostatic
Furthermore,
all
improved
healing
in
full-thickness
defect
skin
test
mice.
size
by
OSD/CMC/Fe/PA3
+
NIR
was
much
smaller
(12%)
than
control
group
treated
Tegaderm™
film
14
days.
conclusion,
have
high
efficiency,
conductivity,
great
biocompatibility,
hemostasis
making
them
promising
candidates
treatment
wounds.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
ACS Nano,
Год журнала:
2023,
Номер
17(21), С. 22015 - 22034
Опубликована: Окт. 20, 2023
Developing
injectable
antiswelling
and
high-strength
bioactive
hydrogels
with
wet
tissue
adhesiveness
a
rapid
gelling
process
to
meet
the
requirements
for
hemostasis,
sutureless
wound
closure,
scar-free
repair
of
infected
skin
wounds
continues
have
ongoing
challenges.
Herein,
injectable,
antibacterial,
antioxidant
hydrogel
adhesives
based
on
poly(citric
acid-co-polyethylene
glycol)-g-dopamine
amino-terminated
Pluronic
F127
(APF)
micelles
loaded
astragaloside
IV
(AS)
are
prepared.
The
H2O2/horseradish
peroxidase
(HRP)
system
is
used
cause
cross-linking
network
through
oxidative
coupling
between
catechol
groups
chemical
group
amino
group.
exhibit
process,
high
mechanical
strength,
an
effect,
good
property,
H2O2
release
behavior,
degradability.
In
addition,
present
adhesiveness,
bursting
pressure,
excellent
antibacterial
activity,
long-term
sustained
AS,
biocompatibility.
perform
hemostasis
mouse
liver,
rat
rabbit
femoral
vein
bleeding
models
achieve
much
better
closure
healing
incisions
than
biomedical
glue
surgical
sutures.
Furthermore,
dressing
significantly
improved
MRSA-infected
full
thickness
defect
by
modulating
inflammation,
regulating
ratio
collagen
I/III,
improving
vascularization
granulation
formation.
Thus,
AS-loaded
show
huge
potential
as
multifunctional
dressings
in
vivo
wounds.
Chemical Science,
Год журнала:
2023,
Номер
14(12), С. 3091 - 3116
Опубликована: Янв. 1, 2023
This
work
reviewed
the
new
progress
of
conductive
hydrogels
in
application
tissue
repair
and
provided
a
useful
reference
for
further
preparation
safer
more
efficient
engineering.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(41)
Опубликована: Июнь 13, 2023
Abstract
Hydrogels
have
been
widely
explored
to
adapt
different
application
circumstances.
As
typical
wet‐soft
materials,
the
high‐water
content
of
hydrogels
is
beneficial
their
wide
biomedical
applications.
Moreover,
displaying
considerable
potential
in
some
high‐tech
areas,
like
brain‐computer
interface,
intelligent
actuator,
flexible
sensor,
etc.
However,
traditional
hydrogel
susceptive
freezing
below
zero,
dehydration,
performance
swelling‐induced
deformation,
and
suffers
from
mechanical
damage
extremely
environments,
which
result
loss
peculiarities
(e.g.,
flexibility,
structure
integrity,
transparency),
greatly
limiting
Therefore,
reducing
point,
improving
dehydration/solution
resistance,
designing
adaptability
are
effective
strategies
endow
with
extreme
environmental
adaptability,
thus
broadening
fields.
This
review
systematically
summarizes
research
advances
environmentally
adaptive
(EAHs),
comprising
anti‐freezing,
dehydration‐resistant,
acid/base/swelling
deformation‐resistant,
environment
(MEAHs).
Firstly,
fabrication
methods
presented,
including
deep
eutectic
solvent/ionic
liquid
substituent,
addition
salts,
organogel,
polymer
network
modification,
double
(DN)
complex/nanocomposite
strategy,
Meanwhile,
features
approaches
overviewed.
The
mechanisms,
properties,
applications
wound
dressing,
sensor)
EAHs
demonstrated.
Finally,
issues
future
perspectives
for
EAHs’
researches
