Composite patch with negative Poisson's ratio mimicking cardiac mechanical properties: Design, experiment and simulation DOI Creative Commons
Zhicheng Dong, Xiaoyang Ren, Ben Jia

и другие.

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101098 - 101098

Опубликована: Май 22, 2024

Developing patches that effectively merge intrinsic deformation characteristics of cardiac with superior tunable mechanical properties remains a crucial biomedical pursuit. Currently used traditional block-shaped or mesh patches, typically incorporating positive Poisson's ratio, often fall short matching the tissue satisfactorily, thus diminishing their repairing capability. By introducing auxeticity into this study is trying to present beneficial approach address these shortcomings patches. The featuring auxetic effect, offer unparalleled conformity complex challenges. Initially, scaffolds demonstrating effect were designed by merging chiral rotation and concave angle units, followed integrating composite hydrogel through thermally triggering, ensuring excellent biocompatibility closely mirroring heart tissue. Tensile tests revealed possessed elasticity strain capacity exceeding tissue's physiological activity. Notably, Model III showed an equivalent modulus ratio toward tissue, underscoring its outstanding potential as Cyclic tensile loading demonstrated withstood continuous heartbeats, showcasing cyclic recovery capabilities. Numerical simulations further elucidated failure mechanisms leading exploration influence on alternative design parameters, which enabled customization strength ratio. Therefore, research presents substantial for designing can emulate possess adjustable parameters.

Язык: Английский

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview DOI Creative Commons
Hoc Thang Nguyen,

Truong Bach Chien,

Đặng Xuân Cường

и другие.

Gels, Год журнала: 2023, Номер 9(7), С. 523 - 523

Опубликована: Июнь 27, 2023

Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.

Язык: Английский

Процитировано

316

Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing DOI Creative Commons
Lipeng Qiao, Yongping Liang, Jueying Chen

и другие.

Bioactive Materials, Год журнала: 2023, Номер 30, С. 129 - 141

Опубликована: Июль 28, 2023

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. this study, series adhesive conductive antibacterial hydrogel based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair infected wound. The Schiff base and Fe3+ coordination bonds structure are dynamic can be repaired automatically after network disrupted. Macroscopically, exhibits properties, allowing dressing adapt complex surfaces. OSD/CMC/Fe/PA showed conductivity photothermal properties under near-infrared (NIR) light irradiation. addition, hydrogels exhibit tunable rheological suitable mechanical antioxidant tissue adhesion hemostatic Furthermore, all improved healing in full-thickness defect skin test mice. size by OSD/CMC/Fe/PA3 + NIR was much smaller (12%) than control group treated Tegaderm™ film 14 days. conclusion, have high efficiency, conductivity, great biocompatibility, hemostasis making them promising candidates treatment wounds.

Язык: Английский

Процитировано

257

Recent progress of antibacterial hydrogels in wound dressings DOI Creative Commons
Ben Jia, Guowei Li, Ertai Cao

и другие.

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

Процитировано

198

Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds DOI
Xin Zhao,

Jinlong Luo,

Ying Huang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(21), С. 22015 - 22034

Опубликована: Окт. 20, 2023

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness a rapid gelling process to meet the requirements for hemostasis, sutureless wound closure, scar-free repair of infected skin wounds continues have ongoing challenges. Herein, injectable, antibacterial, antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine amino-terminated Pluronic F127 (APF) micelles loaded astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used cause cross-linking network through oxidative coupling between catechol groups chemical group amino group. exhibit process, high mechanical strength, an effect, good property, H2O2 release behavior, degradability. In addition, present adhesiveness, bursting pressure, excellent antibacterial activity, long-term sustained AS, biocompatibility. perform hemostasis mouse liver, rat rabbit femoral vein bleeding models achieve much better closure healing incisions than biomedical glue surgical sutures. Furthermore, dressing significantly improved MRSA-infected full thickness defect by modulating inflammation, regulating ratio collagen I/III, improving vascularization granulation formation. Thus, AS-loaded show huge potential as multifunctional dressings in vivo wounds.

Язык: Английский

Процитировано

101

Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing DOI
Jiahui He, Zhenlong Li,

Jiaxin Wang

и другие.

Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 110985 - 110985

Опубликована: Сен. 9, 2023

Язык: Английский

Процитировано

90

Conductive hydrogels for tissue repair DOI Creative Commons
Yongping Liang, Lipeng Qiao,

Bowen Qiao

и другие.

Chemical Science, Год журнала: 2023, Номер 14(12), С. 3091 - 3116

Опубликована: Янв. 1, 2023

This work reviewed the new progress of conductive hydrogels in application tissue repair and provided a useful reference for further preparation safer more efficient engineering.

Язык: Английский

Процитировано

86

Environmentally Adaptive Polymer Hydrogels: Maintaining Wet‐Soft Features in Extreme Conditions DOI
Kun Lei, Meijun Chen,

Pengshan Guo

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(41)

Опубликована: Июнь 13, 2023

Abstract Hydrogels have been widely explored to adapt different application circumstances. As typical wet‐soft materials, the high‐water content of hydrogels is beneficial their wide biomedical applications. Moreover, displaying considerable potential in some high‐tech areas, like brain‐computer interface, intelligent actuator, flexible sensor, etc. However, traditional hydrogel susceptive freezing below zero, dehydration, performance swelling‐induced deformation, and suffers from mechanical damage extremely environments, which result loss peculiarities (e.g., flexibility, structure integrity, transparency), greatly limiting Therefore, reducing point, improving dehydration/solution resistance, designing adaptability are effective strategies endow with extreme environmental adaptability, thus broadening fields. This review systematically summarizes research advances environmentally adaptive (EAHs), comprising anti‐freezing, dehydration‐resistant, acid/base/swelling deformation‐resistant, environment (MEAHs). Firstly, fabrication methods presented, including deep eutectic solvent/ionic liquid substituent, addition salts, organogel, polymer network modification, double (DN) complex/nanocomposite strategy, Meanwhile, features approaches overviewed. The mechanisms, properties, applications wound dressing, sensor) EAHs demonstrated. Finally, issues future perspectives for EAHs’ researches

Язык: Английский

Процитировано

66

Multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesives with high stretchability and rapid self-healing for MRSA infected motion skin wound healing DOI
Wenzhi Wang, Ben Jia,

Huiru Xu

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 468, С. 143362 - 143362

Опубликована: Май 16, 2023

Язык: Английский

Процитировано

64

A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy DOI
Sankha Bhattacharya, Bhupendra G. Prajapati, Sudarshan Singh

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2023, Номер 185, С. 103961 - 103961

Опубликована: Март 13, 2023

Язык: Английский

Процитировано

59

Hydrogels as promising platforms for solar-driven water evaporators DOI

Xinyu Jing,

Fangfei Liu, Tursun Abdiryim

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 479, С. 147519 - 147519

Опубликована: Ноя. 19, 2023

Язык: Английский

Процитировано

53