Current
sprayable
hydrogel
masks
lack
the
stepwise
protection,
cleansing,
and
nourishment
of
extensive
wounds,
leading
to
delayed
healing
with
scarring.
Here,
we
develop
a
biomimetic
double
wound
mask
(BDM)
rapid
autophasing
hierarchical
programming
for
scarless
healing.
The
BDMs
comprise
hydrophobic
poly
(lactide-
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6610 - 6610
Опубликована: Июнь 15, 2024
Skin
is
the
largest
organ
in
human
body
and
requires
proper
dressing
to
facilitate
healing
after
an
injury.
Wounds
on
movable
parts,
such
as
elbow,
knee,
wrist,
neck,
usually
undergo
delayed
inefficient
due
frequent
movements.
To
better
accommodate
wounds,
a
variety
of
functional
hydrogels
have
been
successfully
developed
used
flexible
wound
dressings.
On
one
hand,
mechanical
properties,
adhesion,
stretchability,
self-healing,
make
these
suitable
for
mobile
wounds
promote
process;
other
bioactivities,
antibacterial
antioxidant
performance,
could
further
accelerate
process.
In
this
review,
we
focus
recent
advances
hydrogel-based
dressings
propose
challenges
perspectives
Macromolecular Rapid Communications,
Год журнала:
2022,
Номер
43(21)
Опубликована: Июль 17, 2022
In
recent
years,
natural
polymer-based
electrospun
fibers
(EFs)
with
huge
specific
surface
area,
good
biocompatibility,
and
biological
activity
obtained
from
electrospinning
process
exhibit
tremendous
vitality
in
the
field
of
biomedical
areas.
Herein,
parameters
two
perspectives,
polymer
solution
such
as
solvent,
polymeric
relative
molecular
mass,
concentration,
viscosity,
conductivity
solution,
spinning
voltage,
flow
rate,
needle
tip
to
collector
distance,
temperature,
humidity
are
first
detailed.
Next,
raw
materials
consisting
polysaccharides
cellulose,
hyaluronic
acid,
alginate,
chitosan
well
proteins
collagen,
gelatin,
silk
fibroin,
keratin
summarized.
The
preparation
method
related
characteristics
EFs
multistage
structures
porous,
core-shell,
Janus,
bamboo-like
other
introduced.
applications
these
mainly
including
tissue
engineering,
drug
sustained
release,
wound
dressings,
sensors
systematically
recapitulated.
Finally,
outlook
on
is
further
proposed.
Hydrogels
are
widely
used
in
wound
dressings
due
to
their
moisturizing
properties
and
biocompatibility.
However,
traditional
hydrogel
cannot
monitor
wounds
provide
accurate
treatment.
Recent
advancements
focus
on
with
integrated
monitoring
treatment
functions,
using
sensors
or
intelligent
materials
detect
changes
the
microenvironment.
These
enable
responsive
promote
healing.
They
can
carry
out
dynamic
time
effectively
there
is
still
a
lack
of
comprehensive
reviews
that
incorporate
both
micro-environment
functions.
Therefore,
this
review
categorizes
according
types
examines
current
status,
progress,
challenges,
future
trends.
It
discusses
various
types,
including
infected
wounds,
burns,
diabetic
pressure
ulcers,
explores
healing
process.
The
presents
conditions
tailored
treatment,
such
as
pH-sensitive,
temperature-sensitive,
glucose-sensitive,
pressure-sensitive,
nano-composite
dressings.
Challenges
include
developing
meet
standards
excellent
biocompatibility,
improving
accuracy
sensitivity,
overcoming
obstacles
production
commercialization.
Furthermore,
it
provides
trends
field,
aiming
give
clear
view
its
past,
present,
future.